Measurements at the single-entity level provide more precise diagnosis and understanding of basic biological and chemical processes.Recent advances in the chemical measurement provide a means for ultra-sensitive analy...Measurements at the single-entity level provide more precise diagnosis and understanding of basic biological and chemical processes.Recent advances in the chemical measurement provide a means for ultra-sensitive analysis.Confining the single analyte and electrons near the sensing interface can greatly enhance the sensitivity and selectivity.In this review,we summarize the recent progress in single-entity electrochemistry of single molecules,single particles,single cells and even brain analysis.The benefits of confining these entities to a compatible size sensing interface are exemplified.Finally,the opportunities and challenges of single entity electrochemistry are addressed.展开更多
基金funding from National Natural Science Foundation of China(21834001,21925403,21874070,21790390,21790391,61901171)sponsored by National Ten Thousand Talent Program for young topnotch talent,funding from the European Union’s Horizon 2020research and innovation programme under the Marie Skodowska-Curie grant agreement No 812398,funding supported by the Strategic Priority Research Program of Chinese Academy of Sciences(XDB30000000)+5 种基金the National Basic Research Program of China(2018YFE0200800,2018YFA0703501 and 2016YFA0200104)the Chinese Academy of Sciences(QYZDJSSW-SLH030)funding from Office of Naval Research(N00014-19-1-2331)the US Air Force Office of Scientific Research MURI(FA9550-14-1-0003)the Nanostructures for Electrical Energy Storage(NEES)an Energy Frontier Research Center funded by the US Department of Energy,Office of Science and Basic Energy Sciences under Award number DESC0001160,support from the Office of Naval Research DURIP program(N00014-18-1-2235)。
文摘Measurements at the single-entity level provide more precise diagnosis and understanding of basic biological and chemical processes.Recent advances in the chemical measurement provide a means for ultra-sensitive analysis.Confining the single analyte and electrons near the sensing interface can greatly enhance the sensitivity and selectivity.In this review,we summarize the recent progress in single-entity electrochemistry of single molecules,single particles,single cells and even brain analysis.The benefits of confining these entities to a compatible size sensing interface are exemplified.Finally,the opportunities and challenges of single entity electrochemistry are addressed.
