Objective:To determine the growth pattern of girls with idiopathic precocious puberty (IPP) from birth until diagnosis.Study design:We studied 47 girls with IPP and 35 control girls. In each subject,height and weight ...Objective:To determine the growth pattern of girls with idiopathic precocious puberty (IPP) from birth until diagnosis.Study design:We studied 47 girls with IPP and 35 control girls. In each subject,height and weight were measured at diagnosis,whereas data on height from birth until diagnosis were taken from the personal health book of the patient. Height standard deviation score (HSDS) and body mass index SDS were calculated. Results:Mean age (±SD) of the girls with IPP was 7.6 (1.1) years and of control girls was 7.5 (0.9) years.At birth,HSDS of the patients with IPP was -0.01 (0.8); at the age of 2 years,0.42 (1.2); at the age of 4 years,0.64 (1.1); and at diagnosis,1.23 (1.7) (P < 0.001). HSDS of control girls was 0.02 (0.8) at birth,0.25 (0.8) at 2 years,0.12 (0.9) at 4 years,and 0.19 (1.1) at assessment (P > 0.05). There was no statistical difference between body mass index SDS of the patients 0.6(1.1) versus that of control girls 0.5 (1.0). Conclusions:The early growth acceleration pattern may be used as an additional clue to the diagnosis of idiopathic precocious puberty.展开更多
Nine male infants who developed scrotal hair with no othersigns of virilization were evaluated. Median age for the development of scrotal hair was 4.5 months,and median age at presentation was 7.5 months. Endocrinolog...Nine male infants who developed scrotal hair with no othersigns of virilization were evaluated. Median age for the development of scrotal hair was 4.5 months,and median age at presentation was 7.5 months. Endocrinologic investigations performed in 6 of the infants yielded normal findings. The scrotal hair receded at a mean age of 12 months,suggesting a transient benign event. The development of genital hair in boys under age 9 years is considered precocious,suggesting a possible pathological condition (eg,precocious puberty,congenital adrenal hyperplasia,adrenal or genital tumors),or maybe due to premature adrenarche.展开更多
文摘Objective:To determine the growth pattern of girls with idiopathic precocious puberty (IPP) from birth until diagnosis.Study design:We studied 47 girls with IPP and 35 control girls. In each subject,height and weight were measured at diagnosis,whereas data on height from birth until diagnosis were taken from the personal health book of the patient. Height standard deviation score (HSDS) and body mass index SDS were calculated. Results:Mean age (±SD) of the girls with IPP was 7.6 (1.1) years and of control girls was 7.5 (0.9) years.At birth,HSDS of the patients with IPP was -0.01 (0.8); at the age of 2 years,0.42 (1.2); at the age of 4 years,0.64 (1.1); and at diagnosis,1.23 (1.7) (P < 0.001). HSDS of control girls was 0.02 (0.8) at birth,0.25 (0.8) at 2 years,0.12 (0.9) at 4 years,and 0.19 (1.1) at assessment (P > 0.05). There was no statistical difference between body mass index SDS of the patients 0.6(1.1) versus that of control girls 0.5 (1.0). Conclusions:The early growth acceleration pattern may be used as an additional clue to the diagnosis of idiopathic precocious puberty.
文摘Nine male infants who developed scrotal hair with no othersigns of virilization were evaluated. Median age for the development of scrotal hair was 4.5 months,and median age at presentation was 7.5 months. Endocrinologic investigations performed in 6 of the infants yielded normal findings. The scrotal hair receded at a mean age of 12 months,suggesting a transient benign event. The development of genital hair in boys under age 9 years is considered precocious,suggesting a possible pathological condition (eg,precocious puberty,congenital adrenal hyperplasia,adrenal or genital tumors),or maybe due to premature adrenarche.
