The musculoskeletal system involves multiple tissues which are constantly exposed to being exposed to various biological and mechanical stimuli.As such,isolating and studying a particular system from a complex human c...The musculoskeletal system involves multiple tissues which are constantly exposed to being exposed to various biological and mechanical stimuli.As such,isolating and studying a particular system from a complex human clinical environment is not always a realistic expectation.On top of that,recruitment limitations,in addition to the nature of orthopaedic interventions and their associated cost,sometimes preclude consideration of human trials to answer a clinical question.Therefore,in this mini review,we sought to rationalize the rapid evolution of biomedical research at a basic scientific level and explain why the perception of orthopaedic conditions has fundamentally changed over the last decades.In more detail,we highlight that the number of orthopaedic in vitro publications has soared since 1990.Last but not least,we elaborated on the minimum requirements for conducting a scientifically sound infection-related laboratory experiment to offer valuable information to clinical practitioners.We also explained the rationale behind implementing molecular biology techniques,ex vivo experiments,and artificial intelligence in this type of laboratory research.展开更多
Introduction The prevalence of obesity has increased over the last decades reaching epidemic proportions:39%of adults were overweight or obese in 2016 worldwide,according to World Health Association(https://www.who.in...Introduction The prevalence of obesity has increased over the last decades reaching epidemic proportions:39%of adults were overweight or obese in 2016 worldwide,according to World Health Association(https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight).Moreover,obesity is linked to metabolic syndrome(MetS)and related comorbidities,including nonalcoholic fatty liver disease(NAFLD),type 2 diabetes mellitus(T2DM),cardiovascular disease(CVD)and malignancies,thus resulting in higher mortality for obese individuals(1).展开更多
文摘The musculoskeletal system involves multiple tissues which are constantly exposed to being exposed to various biological and mechanical stimuli.As such,isolating and studying a particular system from a complex human clinical environment is not always a realistic expectation.On top of that,recruitment limitations,in addition to the nature of orthopaedic interventions and their associated cost,sometimes preclude consideration of human trials to answer a clinical question.Therefore,in this mini review,we sought to rationalize the rapid evolution of biomedical research at a basic scientific level and explain why the perception of orthopaedic conditions has fundamentally changed over the last decades.In more detail,we highlight that the number of orthopaedic in vitro publications has soared since 1990.Last but not least,we elaborated on the minimum requirements for conducting a scientifically sound infection-related laboratory experiment to offer valuable information to clinical practitioners.We also explained the rationale behind implementing molecular biology techniques,ex vivo experiments,and artificial intelligence in this type of laboratory research.
文摘Introduction The prevalence of obesity has increased over the last decades reaching epidemic proportions:39%of adults were overweight or obese in 2016 worldwide,according to World Health Association(https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight).Moreover,obesity is linked to metabolic syndrome(MetS)and related comorbidities,including nonalcoholic fatty liver disease(NAFLD),type 2 diabetes mellitus(T2DM),cardiovascular disease(CVD)and malignancies,thus resulting in higher mortality for obese individuals(1).
