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术前肌电图和脑干听觉诱发电位与面肌痉挛微血管减压术后迟发性面瘫发生的关系(英文) 被引量:13
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作者 Kim HJ park ys +6 位作者 Ryu JS Huh R Han I Shin DA Kim TG Cho KG Chung SS 《中华神经外科疾病研究杂志》 CAS 2012年第4期326-326,共1页
Background Delayed facial palsy ( DFP) after microvascular decompression ( MVD) in patients with hemifacial spasm ( HFS) is not uncommon,but the cause remains unknown. Objectives To assess whether intraoperative elect... Background Delayed facial palsy ( DFP) after microvascular decompression ( MVD) in patients with hemifacial spasm ( HFS) is not uncommon,but the cause remains unknown. Objectives To assess whether intraoperative electromyography ( EMG) and brainstem auditory evoked potential ( BAEP) can predict DFP after MVD. Methods Between September 2009 and February 2011 we examined 86 patients,9 of whom ( 10. 4% ) developed DFP after MVD on the same side. All patients underwent MVD and were followed - up for a median period of 13 months ( range 6-22) . We retrospectively examined intraoperative facial EMG and BAEP findings using our MVD patients' registry. We excluded secondary HFS and immediate postoperative facial palsy after MVD in this study. We assessed the prevalence and clinical characteristics of DFP and compared EMG and BAEP findings between DFP and non-DFP groups. Results: All pa- tients recovered completely,with a mean time to recovery of 37. 8 days ( range 22-57) . There were no significant differences between DFP and non - DFP patients in terms of the amplitude and latency of intraoperative EMG and BAEP. Conclusion The usefulness of intraoperative facial EMG and BAEP is limited and cannot predict DFP after MVD for HFS. We speculate that DFP after MVD is not associated with permanent nerve damage according to the EMG findings. 展开更多
关键词 术前肌电图 脑干听觉 面肌痉挛 微血管减压术
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抗中东呼吸综合征冠状病毒棘突蛋白单抗的研究
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作者 Goo J Jeong Y +1 位作者 park ys 吕新军(编译) 《中华实验和临床病毒学杂志》 CAS CSCD 2021年第1期120-120,共1页
中东呼吸综合征冠状病毒(Middle East respiratory syndrome coronavirus,MERS-CoV)引起严重肺部感染,死亡率约为35%。MERS-CoV棘突糖蛋白(S)介导病毒宿主细胞的穿入和膜融合,是疫苗和治疗的关键靶点。本研究采用杆状病毒系统表达4种不... 中东呼吸综合征冠状病毒(Middle East respiratory syndrome coronavirus,MERS-CoV)引起严重肺部感染,死亡率约为35%。MERS-CoV棘突糖蛋白(S)介导病毒宿主细胞的穿入和膜融合,是疫苗和治疗的关键靶点。本研究采用杆状病毒系统表达4种不同的S亚单位蛋白:受体结合域(receptor-binding domain,RBD;358-606 aa)、S1(1-751 aa)、S2(752-1296 aa)和SΔTM(1-1296 aa),并免疫小鼠制备中和抗体。 展开更多
关键词 中和抗体 宿主细胞 膜融合 受体结合域 介导病毒 糖蛋白
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