Post-transplantation malignancies are well known complications after liver transplantation. Certain malignancies are more common in pediatric recipients than adults. Inflammatory myofibroblastic tumors (IMTs) are reac...Post-transplantation malignancies are well known complications after liver transplantation. Certain malignancies are more common in pediatric recipients than adults. Inflammatory myofibroblastic tumors (IMTs) are reactive neoplasms with miniscule malignant potential. IMTs are more common after hematopoietic stem cell transplantation. However, there is 1 case reported in the literature after deceased donor liver transplantation. The authors describe a case of IMT after living donor liver transplantation. The patient was a 1-year-old girl who underwent living donor liver transplantation (LDLT) for decompensated cirrhosis secondary to extra hepatic biliary atresia. Six months post LDLT routine ultrasonography revealed multiple solid abdominal masses. Repeated biopsies were inconclusive. Hence surgical excision was carried out. Histopathological examination revealed IMT. Immunohistochemistry was positive for anaplastic-lymphoma kinase activity. Ceritinib, a tyrosine kinase inhibitor, was used as adjuvant chemotherapy for 1 year. At 1.5 years (at the time of writing this paper) of follow-up, the child was disease free on imaging (whole body positron emission tomography-computed tomography). This will be the first case of IMT after LDLT to be reported in the literature.展开更多
文摘Post-transplantation malignancies are well known complications after liver transplantation. Certain malignancies are more common in pediatric recipients than adults. Inflammatory myofibroblastic tumors (IMTs) are reactive neoplasms with miniscule malignant potential. IMTs are more common after hematopoietic stem cell transplantation. However, there is 1 case reported in the literature after deceased donor liver transplantation. The authors describe a case of IMT after living donor liver transplantation. The patient was a 1-year-old girl who underwent living donor liver transplantation (LDLT) for decompensated cirrhosis secondary to extra hepatic biliary atresia. Six months post LDLT routine ultrasonography revealed multiple solid abdominal masses. Repeated biopsies were inconclusive. Hence surgical excision was carried out. Histopathological examination revealed IMT. Immunohistochemistry was positive for anaplastic-lymphoma kinase activity. Ceritinib, a tyrosine kinase inhibitor, was used as adjuvant chemotherapy for 1 year. At 1.5 years (at the time of writing this paper) of follow-up, the child was disease free on imaging (whole body positron emission tomography-computed tomography). This will be the first case of IMT after LDLT to be reported in the literature.
