Context: Gonococcal infections are prevalent throughout the world and remain a serious public health problem, with an estimated 106.1 million new infections per year. Over recent years, the gonococcus has rapidly acqu...Context: Gonococcal infections are prevalent throughout the world and remain a serious public health problem, with an estimated 106.1 million new infections per year. Over recent years, the gonococcus has rapidly acquired resistance to commonly used antibiotics and very few treatment options remain;hence, regular monitoring of antimicrobial resistance is very important. Methods and Material: The study was conducted from January 2012 to March 2013 after approved by IRB & HREC in patients attending O&G and Skin & VD with the complaints of vaginal discharge, cervical discharge, urethral discharge, dyspareunia, burning micturition, lower abdominal pain & infertility. Endocervical swabs and urethral swabs were collected and cultured on chocolate agar andmodified Thayer martin medium identification of organism was done by biochemical tests and antimicrobial susceptibility testing was done by Kirby-Bauer disk diffusion method as per CLSI guidelines. Results: FiveNeisseria were isolated in male (2.3%) patients of reproductive age group (20 - 30years) with one found reactive for HIV. All patients had history of heterosexual contact of 10 - 12 days before onset of urethral discharge and burning micturition. All isolates were resistant to Penicillin, Tetracycline and Ciprofloxacin. Only one isolate was resistance to Azithromycin. Conclusions: There is a development of resistance in gonococcal isolates to third generation cephalosporin and azithromycin and these are the drugs that are given for syndromic management of cases as per NACO guidelines. So surveillance for antimicrobial resistance is crucial for monitoring the emergence and spread of antibiotic resistance in gonococcal isolates.展开更多
文摘Context: Gonococcal infections are prevalent throughout the world and remain a serious public health problem, with an estimated 106.1 million new infections per year. Over recent years, the gonococcus has rapidly acquired resistance to commonly used antibiotics and very few treatment options remain;hence, regular monitoring of antimicrobial resistance is very important. Methods and Material: The study was conducted from January 2012 to March 2013 after approved by IRB & HREC in patients attending O&G and Skin & VD with the complaints of vaginal discharge, cervical discharge, urethral discharge, dyspareunia, burning micturition, lower abdominal pain & infertility. Endocervical swabs and urethral swabs were collected and cultured on chocolate agar andmodified Thayer martin medium identification of organism was done by biochemical tests and antimicrobial susceptibility testing was done by Kirby-Bauer disk diffusion method as per CLSI guidelines. Results: FiveNeisseria were isolated in male (2.3%) patients of reproductive age group (20 - 30years) with one found reactive for HIV. All patients had history of heterosexual contact of 10 - 12 days before onset of urethral discharge and burning micturition. All isolates were resistant to Penicillin, Tetracycline and Ciprofloxacin. Only one isolate was resistance to Azithromycin. Conclusions: There is a development of resistance in gonococcal isolates to third generation cephalosporin and azithromycin and these are the drugs that are given for syndromic management of cases as per NACO guidelines. So surveillance for antimicrobial resistance is crucial for monitoring the emergence and spread of antibiotic resistance in gonococcal isolates.
