The article by Kulkarni et al.provides a description of some genetic and epigenetic interactions that determine the functional phenotypes of the chemokine receptor CCR5,which is critical to human immunodeficiency viru...The article by Kulkarni et al.provides a description of some genetic and epigenetic interactions that determine the functional phenotypes of the chemokine receptor CCR5,which is critical to human immunodeficiency virus type 1(HIV-1)infection.1 Significant advances in the genetic regulation of human diseases have been made through the use of genome-wide association studies(GWASs)over the past several years.The daunting task of elucidating the cellular pathways that are critical to human disease regulation remains for many disease-associated coding genetic variants.展开更多
文摘The article by Kulkarni et al.provides a description of some genetic and epigenetic interactions that determine the functional phenotypes of the chemokine receptor CCR5,which is critical to human immunodeficiency virus type 1(HIV-1)infection.1 Significant advances in the genetic regulation of human diseases have been made through the use of genome-wide association studies(GWASs)over the past several years.The daunting task of elucidating the cellular pathways that are critical to human disease regulation remains for many disease-associated coding genetic variants.
