AIM： To report long-term outcomes of secondary glaucoma due to uveitis treated with Ahmed glaucoma valve（AGV） implantation in a series of Chinese patients. METHODS： The retrospective study included 67 eyes from 56...AIM： To report long-term outcomes of secondary glaucoma due to uveitis treated with Ahmed glaucoma valve（AGV） implantation in a series of Chinese patients. METHODS： The retrospective study included 67 eyes from 56 patients with uveitic glaucoma who underwent AGV implantation. Success of the treatment was defined as patients achieving intraocular pressure（IOP） levels between 6 and 21 mm Hg with or without additional antiglaucoma medications and/or a minimum of 20% reduction from baseline IOP. The main outcome measurements included IOP, the number of glaucoma medications at 1, 3, 6, 12, 24, 36, 48 and 60 mo after surgery, surgical complications, final best-corrected vision acuity（BCVA）, visual field（VF） and retinal nerve fiber layer（RNFL）.RESULTS： The mean follow-up was 53.3±8.5（range 48 to 60）mo. The cumulative probability of success rate was 98.5%, 95.5%, 89.6%, 83.6%, 76.1%, 70.1%, 65.7% and 61.2% at 1, 3, 6, 12, 24, 36, 48 and 60 mo, respectively. IOP was reduced from a baseline of 30.8±6.8 to 9.9±4.1, 10.1±4.2, 10.9±3.7, 12.9±4.6, 13.8±3.9, 13.2±4.6, 12.3±3.5 and 13.1±3.7 mm Hg at 1, 3, 6, 12, 24, 36, 48 and 60 mo, respectively（P〈0.01）. The number of postoperative glaucoma medications was significantly decreased compared with baseline at all time points during the study period（P〈0.05）. There was no significant difference between preoperative and postoperative BCVA. Remarkable surgical complications were not found after surgery. The VF and RNFL of the patients were stable after the surgery.CONCLUSION： AGV implantation is safe and effect in terms of reducing IOP, decreasing the number of glaucoma medications, and preserving vision for patients with uveitic glaucoma.展开更多
基金Supported by the Key Project of Anhui Provincial Excellent Young Talent Support Program(No.gxyq ZD2017033)the Grant of Second Affiliated Hospital of Anhui Medical University(No.2014BKJ047)Spark Program of the Second Affiliated Hospital of Anhui Medical Univeristy(No.2015hhjh02)
文摘AIM： To report long-term outcomes of secondary glaucoma due to uveitis treated with Ahmed glaucoma valve（AGV） implantation in a series of Chinese patients. METHODS： The retrospective study included 67 eyes from 56 patients with uveitic glaucoma who underwent AGV implantation. Success of the treatment was defined as patients achieving intraocular pressure（IOP） levels between 6 and 21 mm Hg with or without additional antiglaucoma medications and/or a minimum of 20% reduction from baseline IOP. The main outcome measurements included IOP, the number of glaucoma medications at 1, 3, 6, 12, 24, 36, 48 and 60 mo after surgery, surgical complications, final best-corrected vision acuity（BCVA）, visual field（VF） and retinal nerve fiber layer（RNFL）.RESULTS： The mean follow-up was 53.3±8.5（range 48 to 60）mo. The cumulative probability of success rate was 98.5%, 95.5%, 89.6%, 83.6%, 76.1%, 70.1%, 65.7% and 61.2% at 1, 3, 6, 12, 24, 36, 48 and 60 mo, respectively. IOP was reduced from a baseline of 30.8±6.8 to 9.9±4.1, 10.1±4.2, 10.9±3.7, 12.9±4.6, 13.8±3.9, 13.2±4.6, 12.3±3.5 and 13.1±3.7 mm Hg at 1, 3, 6, 12, 24, 36, 48 and 60 mo, respectively（P〈0.01）. The number of postoperative glaucoma medications was significantly decreased compared with baseline at all time points during the study period（P〈0.05）. There was no significant difference between preoperative and postoperative BCVA. Remarkable surgical complications were not found after surgery. The VF and RNFL of the patients were stable after the surgery.CONCLUSION： AGV implantation is safe and effect in terms of reducing IOP, decreasing the number of glaucoma medications, and preserving vision for patients with uveitic glaucoma.
