The etiology of neurodegenerative diseases is diverse,however most of them share common characteristics：accumulation of misfolded proteins,chronic and sustained neuroinflammation,and the dysfunction and death of cert...The etiology of neurodegenerative diseases is diverse,however most of them share common characteristics：accumulation of misfolded proteins,chronic and sustained neuroinflammation,and the dysfunction and death of certain populations of neurons.展开更多
Appropriate nervous system function depends on a precise but plastic neural architecture.Neuronal morphology determines how neurons interact with each other and with other cells.Every kind of neuron has its own morpho...Appropriate nervous system function depends on a precise but plastic neural architecture.Neuronal morphology determines how neurons interact with each other and with other cells.Every kind of neuron has its own morphological characteristics,which are determined by both intrinsic and extrinsic factors.In addition to intrinsic genetic programmes and patterns of neural activity,a variety of extrinsic factors regulate the growth and branching of neural processes and synaptogenesis.展开更多
基金funded by the Spanish Government’s ‘Ministerio de Sanidad y Consumo’ (CIBERNED: CB06/05/1104 and CIBERNED grants PI2010/08 and 2013/01 to JXC)‘Ministerio de Economía y Competitividad’ (SAF2010-19953 and SAF 201347989-R to JXC)+1 种基金the ‘Generalitat de Catalunya’ (Suport als Grups de Recerca Consolidats 2009SGR346)a ‘Beatriu de Pinos’ postdoctoral grant from the ‘Generalitat de Catalunya’ co-financed by the FP7-People-COFUND Programme
文摘The etiology of neurodegenerative diseases is diverse,however most of them share common characteristics：accumulation of misfolded proteins,chronic and sustained neuroinflammation,and the dysfunction and death of certain populations of neurons.
基金supported by the Wellcome Trust (grant No. 103852)。
文摘Appropriate nervous system function depends on a precise but plastic neural architecture.Neuronal morphology determines how neurons interact with each other and with other cells.Every kind of neuron has its own morphological characteristics,which are determined by both intrinsic and extrinsic factors.In addition to intrinsic genetic programmes and patterns of neural activity,a variety of extrinsic factors regulate the growth and branching of neural processes and synaptogenesis.
