Nowadays,holography translates from a pure technical tool for recording the phase and amplitude of the light wave to a widely applicable research-based method.Holographic devices are used for security enhancement,ente...Nowadays,holography translates from a pure technical tool for recording the phase and amplitude of the light wave to a widely applicable research-based method.Holographic devices are used for security enhancement,entertainment,3D display technologies and augmented reality.Binary computer-generated holograms(amplitude or phase-based)are of specific interest.They are easy to compute and their manufacturing methods are fast and robust.In this work,a method of manufacturing amplitude-only binary holograms out of biopolymers films is proposed.Opaque cargo bits made out of different bioactive substances(antibiotics,dyes,etc.)absorb or scatter specific parts of the incoming light wave.Cargo release was conducted by submerging the produced holograms into the aqueous solution at specific pH and temperature levels.Drug elution from the film was traced out by the numerical analysis of the far-field diffraction pattern,which otherwise could only be measured post-factum using sophisticated spectroscopic or chromatography devices.This approach broadens the application of general holography over to the field of biomedical research relevant to quantitative monitoring of the drug elution.展开更多
基金VVT was supported by the grant No.13.2251.21.0009 of the Ministry of Science and Higher Education of the Russian Federation(agreement No.075-15-2021-942)the work was also partly supported by the Siberian State Medical University’s development program Priority 2030.
文摘Nowadays,holography translates from a pure technical tool for recording the phase and amplitude of the light wave to a widely applicable research-based method.Holographic devices are used for security enhancement,entertainment,3D display technologies and augmented reality.Binary computer-generated holograms(amplitude or phase-based)are of specific interest.They are easy to compute and their manufacturing methods are fast and robust.In this work,a method of manufacturing amplitude-only binary holograms out of biopolymers films is proposed.Opaque cargo bits made out of different bioactive substances(antibiotics,dyes,etc.)absorb or scatter specific parts of the incoming light wave.Cargo release was conducted by submerging the produced holograms into the aqueous solution at specific pH and temperature levels.Drug elution from the film was traced out by the numerical analysis of the far-field diffraction pattern,which otherwise could only be measured post-factum using sophisticated spectroscopic or chromatography devices.This approach broadens the application of general holography over to the field of biomedical research relevant to quantitative monitoring of the drug elution.
