In the mammalian central ner vous system, neuronal loss induced by injuries or in neurodegenerative diseases is often irreversible(Quigley, 2016;Gan et al., 2018).Following the disease insult, the surviving neurons ma...In the mammalian central ner vous system, neuronal loss induced by injuries or in neurodegenerative diseases is often irreversible(Quigley, 2016;Gan et al., 2018).Following the disease insult, the surviving neurons may continue to lose their functionality because their axons degenerate and fail to maintain proper synaptic connections, and the underlying molecular and cellular mechanisms remain to be investigated(Raff et al., 2002;Bei et al., 2016;Quigley, 2016).展开更多
基金supported by NIH grants R01EY029121 (to XL and HFZ)R01EY026286 (to XL)。
文摘In the mammalian central ner vous system, neuronal loss induced by injuries or in neurodegenerative diseases is often irreversible(Quigley, 2016;Gan et al., 2018).Following the disease insult, the surviving neurons may continue to lose their functionality because their axons degenerate and fail to maintain proper synaptic connections, and the underlying molecular and cellular mechanisms remain to be investigated(Raff et al., 2002;Bei et al., 2016;Quigley, 2016).
