4-Bromo-3-methylanisole is mainly used to synthesize black fluorane dye(2-anilino-3-methyl-6-dibutylaminofluorane, ODB-2), which is one of the most important heat and pressure-sensitive dyes in the manufacture of ther...4-Bromo-3-methylanisole is mainly used to synthesize black fluorane dye(2-anilino-3-methyl-6-dibutylaminofluorane, ODB-2), which is one of the most important heat and pressure-sensitive dyes in the manufacture of thermal papers. Compared to the industrial heterogeneous batch process, a continuous homogeneous bromination technology in a modular microreaction system has been developed, and 4-bromo-3-methylanisole has been successfully prepared through high-selective mono-bromination of 3-methylanisole with Br2 solution in CHCl3. In optimal conditions, the content of bis-brominated byproducts can be controlled less than 0.5%,which is superior to the industrial standard with 99.5% 3-methylanisole conversion at very short residence time and mild reaction temperature.展开更多
Background:Function of epigenetic modifications is one of the most competitive fields in life science.Over the past several decades,it has been revealed that epigenetic modifications play essential roles in developmen...Background:Function of epigenetic modifications is one of the most competitive fields in life science.Over the past several decades,it has been revealed that epigenetic modifications play essential roles in development and diseases including developmental diseases.In the present review,we summarize the recent progress about the function of epigenetic regulation,especially DNA and RNA modifi cations in developmental diseases.Data sources:Original research articles and literature reviews published in PubMed-indexed journals.Results:DNA modifications including methylation and demethylation can regulate gene expression,and are involved in development and multiple diseases including Rett syndrome,Autism spectrum disorders,congenital heart disease and cancer,etc.RNA methylation and demethylation play important roles in RNA processing,reprogramming,circadian,and neuronal activity,and then modulate development.Conclusions:DNA and RNA modifications play important roles in development and diseases through regulating gene expression.Epigenetic components could serve as novel targets for the treatment of developmental diseases.展开更多
A facile and transition-metal-free method for the synthesis of 4-amino isoquinolin-1(2H)-ones has beendeveloped. Arynes react with 4,5-disubstituted oxazoles through a tandem Diels–Alder reaction/dehydrogenation–aro...A facile and transition-metal-free method for the synthesis of 4-amino isoquinolin-1(2H)-ones has beendeveloped. Arynes react with 4,5-disubstituted oxazoles through a tandem Diels–Alder reaction/dehydrogenation–aromatization/tautamerization process to produce 4-amino isoquinolin-1(2H)-ones in moderate to excellent yields. The reaction can be easily scaled up and the product can be transformed to isoquinoline derivatives efficiently.展开更多
基金financial support from National Key R&D Program of China(2017YFB0307102)National Natural Science Foundation of China(21991100,21991104)。
文摘4-Bromo-3-methylanisole is mainly used to synthesize black fluorane dye(2-anilino-3-methyl-6-dibutylaminofluorane, ODB-2), which is one of the most important heat and pressure-sensitive dyes in the manufacture of thermal papers. Compared to the industrial heterogeneous batch process, a continuous homogeneous bromination technology in a modular microreaction system has been developed, and 4-bromo-3-methylanisole has been successfully prepared through high-selective mono-bromination of 3-methylanisole with Br2 solution in CHCl3. In optimal conditions, the content of bis-brominated byproducts can be controlled less than 0.5%,which is superior to the industrial standard with 99.5% 3-methylanisole conversion at very short residence time and mild reaction temperature.
基金This work was supported by the International Collaboration Program of Science Technology Department of Zhejiang Province(2015C340012016C34004)to Shu Q and Li XQ+2 种基金Zhejiang Provincial Program for the Cultivation of Highlevel Innovative Health talents to Shu Qthe National Key Basic Research Program of China(No.2014CB943001)National Natural Science Foundation of China(No.31371309)to Li XQ.
文摘Background:Function of epigenetic modifications is one of the most competitive fields in life science.Over the past several decades,it has been revealed that epigenetic modifications play essential roles in development and diseases including developmental diseases.In the present review,we summarize the recent progress about the function of epigenetic regulation,especially DNA and RNA modifi cations in developmental diseases.Data sources:Original research articles and literature reviews published in PubMed-indexed journals.Results:DNA modifications including methylation and demethylation can regulate gene expression,and are involved in development and multiple diseases including Rett syndrome,Autism spectrum disorders,congenital heart disease and cancer,etc.RNA methylation and demethylation play important roles in RNA processing,reprogramming,circadian,and neuronal activity,and then modulate development.Conclusions:DNA and RNA modifications play important roles in development and diseases through regulating gene expression.Epigenetic components could serve as novel targets for the treatment of developmental diseases.
基金supported by the National Natural Science Foundation of China(No.22161039)the Excellent Young Teachers Plan of Bingtuan(2017CB001 and CZ027203,CZ002203)the International Cooperation Project of Shihezi University(No.GJHZ201801).
文摘A facile and transition-metal-free method for the synthesis of 4-amino isoquinolin-1(2H)-ones has beendeveloped. Arynes react with 4,5-disubstituted oxazoles through a tandem Diels–Alder reaction/dehydrogenation–aromatization/tautamerization process to produce 4-amino isoquinolin-1(2H)-ones in moderate to excellent yields. The reaction can be easily scaled up and the product can be transformed to isoquinoline derivatives efficiently.
