Objective:To study the chemical constituents in leaves of Cebera manghas.Methods:Chemical constituents were isolated by using various column chromatography and tho structures were elucidated on basis of physicochemica...Objective:To study the chemical constituents in leaves of Cebera manghas.Methods:Chemical constituents were isolated by using various column chromatography and tho structures were elucidated on basis of physicochemical constants and spectral data analysis.Results:Nine compounds were obtained including p-hydroxybenzaldehyde(1),benzamide(2),n-hexadecane acid monoglyceride(3),loliolide(4),β-sitosterol(5),cerberin(6),neriifolin(7),cerleaside A(8), daucosterol(9).Conclusions:Compounds 1-4 are obtained from this genus for the first time.展开更多
The present study carried out a phytochemical investigation on the root barks of Dictamnus dasycarpus Turcz, leading to the isolation and characterization of two new aromatic ring butyrolactone derivatives, dasycarpus...The present study carried out a phytochemical investigation on the root barks of Dictamnus dasycarpus Turcz, leading to the isolation and characterization of two new aromatic ring butyrolactone derivatives, dasycarpusphenol acid A(1) and dasycarpusphenol acid B(2). Their structures were elucidated by using spectroscopic techniques and HR-FAB-MS. Compounds 1 and 2 exhibited antioxidant activity, with their IC_(50) values being 28.95 and 41.76 mg·mL^(-1),respectively.展开更多
The present study was designed to further investigate the C_(21) steroidal glycosides in Cynanchum plants.Two new steroidal glycosides based on a 13,14:14,15-disecopregnane-type aglycone,komaroside P(1) and komaroside...The present study was designed to further investigate the C_(21) steroidal glycosides in Cynanchum plants.Two new steroidal glycosides based on a 13,14:14,15-disecopregnane-type aglycone,komaroside P(1) and komaroside Q(2),together with three known compounds(3-5) were isolated from the whole herbs of Cynanchum komarovii.The aglycones of compounds 1 and 2 were two new disecopregnane.Their structures were elucidated on the basis of 1 D,2 D NMR spectroscopic data and acid hydrolysis.All the compounds(1-5) showed potent inhibitory activities against human leukemia cell lines(HL-60) with IC50 values ranging from 16.6 to 26.3 μmol·L^(-1),compared to the positive control 5-fluorouracil(6.4 μmol·L^(-1)).展开更多
The present study was designed to investigate the chemical constituents of the fruit of Citrus aurantium L.. The compounds were isolated and purified by various chromatographic techniques, and their structures were el...The present study was designed to investigate the chemical constituents of the fruit of Citrus aurantium L.. The compounds were isolated and purified by various chromatographic techniques, and their structures were elucidated on the basis of physicochemical properties and spectral data. Two new phenolic glycosides(compounds 1 and 2) were obtained and identified as 1-O-3, 5-dihydroxyphenyl-(6-O-4-hydroxybenzoyl)-β-D-glucopyranoside(1) and 1-O-3, 5-dihydroxyphenyl-(6-O-3-methoxy-4-hydroxy benzoyl)-β-D-glucopyranoside(2), respectively.展开更多
Two new compounds,(22E)-25-carboxy-8β,14β-epoxy-4α,5α-dihydroxyergosta-2,22-dien-7-one(1) and fusidione(3), along with two known compounds, 5α,8α-epidioxy ergosta-6,22-diene-3β-ol(2) and microperfuranone(4), we...Two new compounds,(22E)-25-carboxy-8β,14β-epoxy-4α,5α-dihydroxyergosta-2,22-dien-7-one(1) and fusidione(3), along with two known compounds, 5α,8α-epidioxy ergosta-6,22-diene-3β-ol(2) and microperfuranone(4), were isolated from the fermentation products of the marine-sourced fungus Acremonium fusidioides RZ01. The structures of compounds 1 and 3 were elucidated by extensive spectroscopic methods, especially 2D NMR, and their absolute configurations were suggested on the basis of the circular dichroism spectral analysis and the NOESY data. Both new compounds showed inhibitory activity against HL-60 cells with IC50 values being16.6 and 44.9 μmol·L-1, respectively.展开更多
基金supported by Hainan Provicinal Key Course Foundation of Medicinal Chemistry
文摘Objective:To study the chemical constituents in leaves of Cebera manghas.Methods:Chemical constituents were isolated by using various column chromatography and tho structures were elucidated on basis of physicochemical constants and spectral data analysis.Results:Nine compounds were obtained including p-hydroxybenzaldehyde(1),benzamide(2),n-hexadecane acid monoglyceride(3),loliolide(4),β-sitosterol(5),cerberin(6),neriifolin(7),cerleaside A(8), daucosterol(9).Conclusions:Compounds 1-4 are obtained from this genus for the first time.
基金This project was supported by the National Natural Science Foundation of China （No.81072546） and the Chi- nese PLA National Science Fund for Distinguished Young Scholars Grant during the 11th ＂Five-Year＂ Plan period （No.06J001）.
基金supported by the Natural Science Foundation of Heilongjiang(No.D201207)
文摘The present study carried out a phytochemical investigation on the root barks of Dictamnus dasycarpus Turcz, leading to the isolation and characterization of two new aromatic ring butyrolactone derivatives, dasycarpusphenol acid A(1) and dasycarpusphenol acid B(2). Their structures were elucidated by using spectroscopic techniques and HR-FAB-MS. Compounds 1 and 2 exhibited antioxidant activity, with their IC_(50) values being 28.95 and 41.76 mg·mL^(-1),respectively.
基金supported by the National Natural Science Foundation of China(No.31370375)
文摘The present study was designed to further investigate the C_(21) steroidal glycosides in Cynanchum plants.Two new steroidal glycosides based on a 13,14:14,15-disecopregnane-type aglycone,komaroside P(1) and komaroside Q(2),together with three known compounds(3-5) were isolated from the whole herbs of Cynanchum komarovii.The aglycones of compounds 1 and 2 were two new disecopregnane.Their structures were elucidated on the basis of 1 D,2 D NMR spectroscopic data and acid hydrolysis.All the compounds(1-5) showed potent inhibitory activities against human leukemia cell lines(HL-60) with IC50 values ranging from 16.6 to 26.3 μmol·L^(-1),compared to the positive control 5-fluorouracil(6.4 μmol·L^(-1)).
基金supported by Specialized Research Fund for the Doctoral Program of Higher Education(SRFDP No.20112134120006)
文摘The present study was designed to investigate the chemical constituents of the fruit of Citrus aurantium L.. The compounds were isolated and purified by various chromatographic techniques, and their structures were elucidated on the basis of physicochemical properties and spectral data. Two new phenolic glycosides(compounds 1 and 2) were obtained and identified as 1-O-3, 5-dihydroxyphenyl-(6-O-4-hydroxybenzoyl)-β-D-glucopyranoside(1) and 1-O-3, 5-dihydroxyphenyl-(6-O-3-methoxy-4-hydroxy benzoyl)-β-D-glucopyranoside(2), respectively.
基金supported by the National Natural Science Foundation of China(No.81502951)
文摘Two new compounds,(22E)-25-carboxy-8β,14β-epoxy-4α,5α-dihydroxyergosta-2,22-dien-7-one(1) and fusidione(3), along with two known compounds, 5α,8α-epidioxy ergosta-6,22-diene-3β-ol(2) and microperfuranone(4), were isolated from the fermentation products of the marine-sourced fungus Acremonium fusidioides RZ01. The structures of compounds 1 and 3 were elucidated by extensive spectroscopic methods, especially 2D NMR, and their absolute configurations were suggested on the basis of the circular dichroism spectral analysis and the NOESY data. Both new compounds showed inhibitory activity against HL-60 cells with IC50 values being16.6 and 44.9 μmol·L-1, respectively.
