Literature review and analysis of the application of health outcome assessment instruments in Chinese medicine

OBJECTIVE： To evaluate the application of health assessment instruments in Chinese medicine. METHODS： According to a pre-defined search strategy, a comprehensive literature search for all articles published in China National Knowledge Infrastructure databases was conducted. The resulting articles that met the defined inclusion and exclusion criteria were used for analysis. RESULTS： A total of 97 instruments for health outcome assessment in Chinese medicine have been used in fundamental and theoretical research, and 14 of these were also used in 29 clinical trials that were randomized controlled trials, or descriptive or cross-sectional studies. In 2 152 Chinese medicine-based studies that used instruments in their methodology, more than 150 questionnaires were identified. Among the identified questionnaires, 51 were used in more than 10 articles （0.5%）. Most of these instruments were developed in Western countries and few studies （4%） used the instrument as the primary evidence for their conclusions. CONCLUSION： Usage of instruments for health outcome assessment in Chinese medicine is increasing rapidly; however, current limitations include selection rationale, result interpretation and standardization, which must be addressed accordingly.

Killing two birds with one stone:ARC-BBBE can simultaneously green control aflatoxin and promote peanut super-nodulation

Peanut(Arachis hypogaea L.)is a dual-purpose crop that supplies vegetable oil and food protein,which plays an important role in agriculture and national economy(Akram et al.,2018).One of the major problems in peanut worldwide is Aspellgills flavus infection and subsequent aflatoxin(AFT)contamination,which can occur during production,harvesting,storage,processing,etc.,thereby seriously threatening people's health and food safety,and restricting export trade(Klich et al.,2007;Ding et al.,2015).AFTs are the most toxic class of mycotoxins discovered to date,which can cause carcinogenicity,teratogenicity and mutagenesis(Smith et al.,2017;Mwakinyali et al.,2019).

Consensus statement on layout and delivery of automatic external defibrillator in China

1.Introduction Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac causes.It is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in China[2].

Autophagy in intestinal injury caused by severe acute pancreatitis

Severe acute pancreatitis(SAP)is a potentially lethal disease with considerable morbidity and mortality.It is often accompanied by systemic inflammatory response syndrome,sepsis.

Progress of pyroptosis in acute pancreatitis

Acute pancreatitis(AP)is a complex abdominal disease with high morbidity and mortality that involves a strong local and systemic inflammatory response.When AP develops into severe acute pancreatitis(SAP),it easily leads to multiple organ dysfunction syndrome,which is also one of the main reasons for death in SAP patients.[1]In the past decade,we have made substantial progress in our understanding of the pathophysiological mechanism of AP.The mechanism of calcium-mediated acinar cell damage and death has been elucidated.The cytoprotective effects of the unfolded protein response and autophagy in preventing continuous endoplasmic reticulum stress,apoptosis,and necrosis has been shown.The central role of unsaturated fatty acids in causing pancreatic organ failure has also been confirmed.In contrast,we know very little about the mechanism of parenchymal cell death.[2]Early and effective regulation of pancreatic acinar cell death may be an effective treatment for AP.In recent years,a new type of cell death called pyroptosis has become an important research topic in the field of inflammation and immune diseases.Recent studies have shown that pyroptosis is involved in the pathogenesis of pancreatic parenchymal cell death.Inhibiting pyroptosis can reduce pancreatic damage and has an important impact on the progression of AP.[3,4]This article reviews the research progress on pyroptosis in AP,with a focus on understanding the pathogenesis of AP and providing references for the identification of new therapeutic targets[Supplementary Figure 1,https://links.lww.com/CM9/A630].