Ligustrazine （2,3,5,6-tetramethylpyrazine） is a major active ingredient of the Szechwan lovage rhizome and is extensively used in treatment of ischemic cerebrovascular disease. The mecha- nism of action of ligustraz...Ligustrazine （2,3,5,6-tetramethylpyrazine） is a major active ingredient of the Szechwan lovage rhizome and is extensively used in treatment of ischemic cerebrovascular disease. The mecha- nism of action of ligustrazine use against ischemic cerebrovascular diseases remains unclear at present. This study summarizes its protective effect, the optimum time window of administra- tion, and the most effective mode of administration for clinical treatment of cerebral ischemia/ reperfusion injury. We examine the effects of ligustrazine on suppressing excitatory amino acid release, promoting migration, differentiation and proliferation of endogenous neural stem cells. We also looked at its effects on angiogenesis and how it inhibits thrombosis, the inflammatory response, and apoptosis after cerebral ischemia. We consider that ligustrazine gives noticeable protection from cerebral ischemia/reperfusion injury. The time window of ligustrazine admin- istration is limited. The protective effect and time window of a series of derivative monomers of ligustrazine such as 2-[（1,1-dimethylethyl）oxidoimino]methyl]-3,5,6-trimethylpyrazine, CXC137 and CXC 195 after cerebral ischemia were better than ligustrazine.展开更多
To the Editor： Out-of-hospital cardiac arrest （OHCA） of cardiac origin is one of the leading causes of death in the industrialized world. The American Heart Association recommended patients who have been successful...To the Editor： Out-of-hospital cardiac arrest （OHCA） of cardiac origin is one of the leading causes of death in the industrialized world. The American Heart Association recommended patients who have been successfully resuscitated from OHCA and whose initial electrocardiogram （ECG） showing ST-segment elevation myocardial infarction （STEMI） should undergo emergent cardiac catheterization with the intent to identify and revascularize the culprit lesion by percutmleous intervention （PCI） when clinically applicable. However, few recent retrospective studies and prospective registries observed a beneficial effect of emergency coronary angiography and PCI on the outcome of resuscitated patients with OHCA.展开更多
基金supported by a grant from the Health and Family Planning Commission of Heilongjiang Province Research Project in China,No.2014-195the Education Department Science and Technology Foundation of Heilongjiang Province in China,No.12531741the Natural Science Foundation of Heilongjiang Province of China,No.H2015083
文摘Ligustrazine （2,3,5,6-tetramethylpyrazine） is a major active ingredient of the Szechwan lovage rhizome and is extensively used in treatment of ischemic cerebrovascular disease. The mecha- nism of action of ligustrazine use against ischemic cerebrovascular diseases remains unclear at present. This study summarizes its protective effect, the optimum time window of administra- tion, and the most effective mode of administration for clinical treatment of cerebral ischemia/ reperfusion injury. We examine the effects of ligustrazine on suppressing excitatory amino acid release, promoting migration, differentiation and proliferation of endogenous neural stem cells. We also looked at its effects on angiogenesis and how it inhibits thrombosis, the inflammatory response, and apoptosis after cerebral ischemia. We consider that ligustrazine gives noticeable protection from cerebral ischemia/reperfusion injury. The time window of ligustrazine admin- istration is limited. The protective effect and time window of a series of derivative monomers of ligustrazine such as 2-[（1,1-dimethylethyl）oxidoimino]methyl]-3,5,6-trimethylpyrazine, CXC137 and CXC 195 after cerebral ischemia were better than ligustrazine.
文摘To the Editor： Out-of-hospital cardiac arrest （OHCA） of cardiac origin is one of the leading causes of death in the industrialized world. The American Heart Association recommended patients who have been successfully resuscitated from OHCA and whose initial electrocardiogram （ECG） showing ST-segment elevation myocardial infarction （STEMI） should undergo emergent cardiac catheterization with the intent to identify and revascularize the culprit lesion by percutmleous intervention （PCI） when clinically applicable. However, few recent retrospective studies and prospective registries observed a beneficial effect of emergency coronary angiography and PCI on the outcome of resuscitated patients with OHCA.
