A new chloro-azaphilone derivative with pro-angiogenesis activity from the hadal trench-derived fungus Chaetomium globosum YP-106

A new chloro-azaphilone derivative chaetoviridin L(1)along with four known analogues,namely,chaetomugilin A(2),chaetoviridin E(3),chaetomugilin O(4),and chaephilone D(5),is isolated and identified from the culture extract of Chaetomium globosum YP-106,a deep-sea derived fungus obtained from the hadal zone seawater collected in the Yap Trench.Their structures were determined based on detailed interpretation of nuclear magnetic resonance(NMR)spectroscopic,mass spectrometry(MS)data analysis and comparison with the reported literature.The absolute configuration of the new compound was established by quantum chemical calculations of electronic circular dichroism(ECD).All the isolated compounds were evaluated for pro-angiogenesis activity using zebra fish model.Compounds 1,2,and 5significantly promoted the angiogenesis in a dose-dependent manner and thus,these compounds might be used as promising molecules for the treatment of cardiovascular disease.

基于智能运维平台的城轨车辆关键部件异常实时监测

为确保城际轨道交通车辆的安全运行,提高部件异常检测的精确度,提出基于智能运维平台的城轨车辆关键部件异常实时监测方法分析。以智能运维平台为依托,通过对目前城轨车辆异常实时监测现状的分析,明确存在的问题,并且提出适当的监测方法,从车辆部件数据采集与存储、构建数据处理框架、制定异常判别标准、优化部件异常判别方法、监测结果展示五个方面来进行实时监测设计。最后,通过实验进行验证,以智能运维平台为基础进行的车辆监测方法具有良好效果。