Dear Editor,To date,seven human coronaviruses(HCoVs)have been identified,among which the highly pathogenic severe acute respiratory syndrome-associated coronavirus(SARS-CoV),Middle East respiratory syndrome coronaviru...Dear Editor,To date,seven human coronaviruses(HCoVs)have been identified,among which the highly pathogenic severe acute respiratory syndrome-associated coronavirus(SARS-CoV),Middle East respiratory syndrome coronavirus(MERS-CoV),and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have caused public health disasters worldwide.展开更多
Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative agent of the unprecedented coronavirus disease 2019(COVID-19).SARS-CoV-2 entry into host cells is mediated by the viral transmemb...Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative agent of the unprecedented coronavirus disease 2019(COVID-19).SARS-CoV-2 entry into host cells is mediated by the viral transmembrane spike(S)glycoprotein that forms homotrimers protruding from the viral surface.展开更多
Dear Editor,The COVID-19 pandemic caused by SARS-CoV-2 has led to acute respiratory distress syndrome(ARDS)with a high rate of death.An excessive inflammatory response,caused by virus infection,is associated with seve...Dear Editor,The COVID-19 pandemic caused by SARS-CoV-2 has led to acute respiratory distress syndrome(ARDS)with a high rate of death.An excessive inflammatory response,caused by virus infection,is associated with severe clinical manifestations that may lead to death of patients.1 Therefore,the blockage of virus replication and suppression of hyper-inflammatory response are beneficial for COVID-19 treatment.However,the drug targeting both virus and hyper-inflammation,as far as we know,is not available yet.展开更多
Dear Editor,COVID-19(Coronavirus Disease 2019)is causing an unprecedented public health crisis.Protein translation is crucial for virus lifecycle.Nucleocapsid(N)protein is among the most abundant SARS-CoV-2 proteins a...Dear Editor,COVID-19(Coronavirus Disease 2019)is causing an unprecedented public health crisis.Protein translation is crucial for virus lifecycle.Nucleocapsid(N)protein is among the most abundant SARS-CoV-2 proteins and highly conserved across coronavirus genus.1 However,its function in subverting host translation machinery is still elusive.展开更多
基金This study was funded by grants from the National Key Research and Development Program(2021YFC2300603)the National Science Foundation of China(32170157,Key program 81830017,and 81902051),Taishan Scholarship(No.tspd20181201)+1 种基金Major Basic Research Project of Shandong Natural Science Foundation(No.ZR2020ZD12)Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong,Key Research and Development Program of Shandong(2019GSF108238).We thank Professor Jincun Zhao(the First Affiliated Hospital of Guangzhou Medical University)for the friendly gifted HCoV-229E virus and S protein expression plasmids of HCoV-NL63 and HCoV-229E.We thank the Translational Medicine Core Facility of Shandong University for the consultation and instrument availability that supported this work.
文摘Dear Editor,To date,seven human coronaviruses(HCoVs)have been identified,among which the highly pathogenic severe acute respiratory syndrome-associated coronavirus(SARS-CoV),Middle East respiratory syndrome coronavirus(MERS-CoV),and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have caused public health disasters worldwide.
基金This study was funded by grants from Taishan Scholarship(No.tspd20181201)the National Science Foundation of China(Key program 81830017 and No.81902051,81902443)+3 种基金the National Natural Science Fund for Outstanding Youth Fund(81425012)Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong,Key Research and Development Program of Shandong(2019GSF108238)the COVID-19 emergency tackling research project of Shandong University(Grant No.2020XGB03)the Natural Science Foundation of Jiangsu Province(BK20200225)。
文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative agent of the unprecedented coronavirus disease 2019(COVID-19).SARS-CoV-2 entry into host cells is mediated by the viral transmembrane spike(S)glycoprotein that forms homotrimers protruding from the viral surface.
基金supported by National Key R&D Program of China[2018YFA0107000]National Natural Science Foundation of China Grants(82025014,31900516,8201101103,81870506,and 21701194)+3 种基金Guangzhou Municipal People's Livelihood Science and technology plan[201803010108]Fundamental Research Funds for Central Universities(20lgpy119,19lgpy177)the China Postdoctoral Science Foundation(2019M653170)Shenzhen Key Medical Discipline Construction Fund(SZXK002)and grant from COVID-19 emergency tackling research project of Shandong University(Grant No.2020XGB03 to P.H.W).
文摘Dear Editor,The COVID-19 pandemic caused by SARS-CoV-2 has led to acute respiratory distress syndrome(ARDS)with a high rate of death.An excessive inflammatory response,caused by virus infection,is associated with severe clinical manifestations that may lead to death of patients.1 Therefore,the blockage of virus replication and suppression of hyper-inflammatory response are beneficial for COVID-19 treatment.However,the drug targeting both virus and hyper-inflammation,as far as we know,is not available yet.
基金National Key Research and Development Program of China,Stem Cell and Translation Research[2018YFA0109300 to P.Q.]National Natural Science Foundation of China[82222003,81870080,91949115,82161138028 to P.Q.+3 种基金31900815 to H.W.]Natural Science Foundation of Zhejiang Province[LR19H080001 to P.Q.]Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang[2020R01006 to P.Q.]Zhejiang Provincial Key Research and Development Program[2021C03043 to H.Y.].We are grateful to W.P.H.(Shandong University)for providing original SARS-CoV-2 protein expressing plasmids.
文摘Dear Editor,COVID-19(Coronavirus Disease 2019)is causing an unprecedented public health crisis.Protein translation is crucial for virus lifecycle.Nucleocapsid(N)protein is among the most abundant SARS-CoV-2 proteins and highly conserved across coronavirus genus.1 However,its function in subverting host translation machinery is still elusive.
