As a representative of chronic wounds,the long-term high levels of oxidative stress and blood sugar in chronic diabetic wounds lead to serious complications,making them the biggest challenge in the research on wound h...As a representative of chronic wounds,the long-term high levels of oxidative stress and blood sugar in chronic diabetic wounds lead to serious complications,making them the biggest challenge in the research on wound healing.Many edible natural biomaterials rich in terpenes,phenols,and flavonoids can act as efficient antioxidants.In this study,okra extract was selected as the main component of a wound dressing.The okra extracts obtained via different methods comprehensively maintained the bioactivity of multiple molecules.The robust antioxidant properties of okra significantly reduced intracellular reactive oxygen species production,thereby accelerating the wound healing process.The results showed that okra extracts and their hydrogel dressings increased cell migration,angiogenesis,and re-epithelization of the chronic wound area,considerably promoting wound remodeling in diabetic rats.Therefore,okra-based hydrogels are promising candidates for skin regeneration and wider tissue engineering applications.展开更多
The last few decades have witnessed the eme rgence of a very large variety of engineered nanomaterials.However,it is far from to meet the growing clinical demand.Actually,nature itself is an excellent na notechnologis...The last few decades have witnessed the eme rgence of a very large variety of engineered nanomaterials.However,it is far from to meet the growing clinical demand.Actually,nature itself is an excellent na notechnologist,and provides us with a range of wonderful materials,from inorganic particles found in non-life bodies to biofilms,like platelets,erythrocyte membranes,produced by many bacteria or cells.These nanomaterials are entirely natural,and not surprisingly,there is a growing interest in the development of natural nanoproducts.Native components-inspired biomaterials have gained considerable attention owing to their sa fety and functions.In this study,egg white was developed as drug carrier to load PTX by a green and simple one-pot method,and systematic characterization was completed.The results indicated that PTX@EW NPs possess excellent biocompatibility,enhanced tumor targeting capability,effectively reducing the toxic side effects of PTX.The obviously enhanced antitumor effect further confirmed EW was a highly prospective biomaterial in the nano-carrier industry.展开更多
基金Thanks to the following fund projects for their support to this work:National Natural Science Foundation of China(Nos.51973243 and 52173150)International Cooperation and Exchange of the National Natural Science Foundation of China(No.51820105004)Shenzhen Basic Research Project(No.JCYJ20190807155801657).
文摘As a representative of chronic wounds,the long-term high levels of oxidative stress and blood sugar in chronic diabetic wounds lead to serious complications,making them the biggest challenge in the research on wound healing.Many edible natural biomaterials rich in terpenes,phenols,and flavonoids can act as efficient antioxidants.In this study,okra extract was selected as the main component of a wound dressing.The okra extracts obtained via different methods comprehensively maintained the bioactivity of multiple molecules.The robust antioxidant properties of okra significantly reduced intracellular reactive oxygen species production,thereby accelerating the wound healing process.The results showed that okra extracts and their hydrogel dressings increased cell migration,angiogenesis,and re-epithelization of the chronic wound area,considerably promoting wound remodeling in diabetic rats.Therefore,okra-based hydrogels are promising candidates for skin regeneration and wider tissue engineering applications.
基金supported by National Science and Technology Major Project of the Ministry of Science and Technology of China (No.2018ZX10301402)International Cooperation and Exchange of the National Natural Science Foundation of China (No.51820105004)+8 种基金China Postdoctoral Science Foundation (No. 2019M663246)the Fundamental Research Funds for the Central Universities (Nos.191gzd35 and 20ykpy15)Guangdong Basic and Applied Basic Research Foundation (No.2019A1515110686)the Seventh Affiliated Hospital of Sun Yat-sen University (Shenzhen) Research Startup Fund (No.ZSQYRSFPD0015)Science and Technology Program of Guangzhou (Nos.201707010094 and 201704020095)Guangdong Innovative and Entrepreneurial Research Team Program (Nos.2016ZT06S252 and 2016ZT06S029)Science and Technology Planning Project of Shenzhen (No.JCYJ20170307141438157)Shenzhen Foundation of Science and Technology (No.JCYJ20170818103626421)National Natural Science Foundation of China (No.51973243)
文摘The last few decades have witnessed the eme rgence of a very large variety of engineered nanomaterials.However,it is far from to meet the growing clinical demand.Actually,nature itself is an excellent na notechnologist,and provides us with a range of wonderful materials,from inorganic particles found in non-life bodies to biofilms,like platelets,erythrocyte membranes,produced by many bacteria or cells.These nanomaterials are entirely natural,and not surprisingly,there is a growing interest in the development of natural nanoproducts.Native components-inspired biomaterials have gained considerable attention owing to their sa fety and functions.In this study,egg white was developed as drug carrier to load PTX by a green and simple one-pot method,and systematic characterization was completed.The results indicated that PTX@EW NPs possess excellent biocompatibility,enhanced tumor targeting capability,effectively reducing the toxic side effects of PTX.The obviously enhanced antitumor effect further confirmed EW was a highly prospective biomaterial in the nano-carrier industry.
