Fusion power supply advances by the J-TEXT engineering team

To meet the stringent requirements of the fusion power supply for large-scale fusion devices,the J-TEXT engineering team has carried out key technology research and applications in several important directions of fusion power supply.This article presents the advances made by the J-TEXT engineering team in recent years in the following areas:(1) a high-voltage power supply for an auxiliary heating system;(2) a breakdown protection device for an auxiliary heating power supply;(3) magnetic field compatibility;(4) a high-voltage pulsed power supply for a fieldreversed configuration;(5) a large physics experimental facility control system.The research backgrounds,technical progress,test results,applications,summaries and prospects are described in detail in each part.These innovative research results and valuable engineering experience can promote the progress of fusion power supply technology,and also lay a foundation for the development of power supplies with higher parameters in the future.

PTPRZ1-METFUsion GENe(ZM-FUGEN)trial:study protocol for a multicentric,randomized,open-label phase II/III trial

Background PTPRZ1-MET fusion was reported to associate with glioma progression from low-grade to high-grade glioma,which was a target by a MET inhibitor vebreltinib.However,little is known about the further efficacy of vebreltinib among more glioma patients.This trial aims to evaluate the safety and efficacy of vebreltinib enteric-coated capsules in the treatment of sGBM/IDH mutant glioblastoma patients with the ZM fusion gene.Methods This multicentric,randomized,open-label,controlled trial plans to include 19 neurosurgical centers and recruit 84 sGBM or IDH mutant glioblastoma patients with the ZM fusion gene.This trial enrolls sGBM or IDH mutant glioblastoma patients with the inclusion criteria and without the exclusion criteria.It was registered with chinadrugtrials.org.cn(CTR20181664).The primary efficacy endpoint is overall survival(OS).The secondary endpoints are progression-free survival(PFS)and objective response rate(ORR).Discussion If proven effective,this targeted multifaceted intervention protocol will be extended for more glioma patients as a protocol to evaluate the safety and efficacy of MET inhibitors.Trial registration It was registered with chinadrugtrials.org.cn(CTR20181664).

Probabilistic method for the size design of energy piles considering the uncertainty in soil parameters

Energy piles have attracted increasing attention as profitable solutions for the utilization of shallow geothermal energy.Although various complex geotechnical design models of energy piles have been proposed,a simplified sizing method that considers the uncertainty propagation in the soil is required.In this study,a Monte Carlo Simulation-based method was proposed for the size design of energy piles considering the uncertainty of parameters in the soil,such as thermal conductivity and friction angle.The small-sample analysis method of Markov chain Monte Carlo simulation combined with the Bayesian theoretical framework was developed to generate equiv-alent samples.Subsequently,the thermal response function and thermomechanical load transfer methods were employed to address the failure probability of the energy pile in the serviceability limit state and ultimate limit state.In addition,a case study was presented to illustrate the implementation of the proposed probabilistic sizing method.The analysis results of the case study confirm the necessity of modeling the soil uncertainty in the energy pile size design.