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Rubicon: a facilitator of viral immune evasion
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作者 peining fang Haisheng Yu +3 位作者 Mengqi Li Rui He Ying Zhu Shi Liu 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2019年第9期770-771,共2页
In a study published in cellular and molecular immunology,Wan et al.demonstrate a new mechanism of viral immune evasion.1 It was observed that Rubicon,the RUN domain Beclin-1-interacting and cysteine-rich domain-conta... In a study published in cellular and molecular immunology,Wan et al.demonstrate a new mechanism of viral immune evasion.1 It was observed that Rubicon,the RUN domain Beclin-1-interacting and cysteine-rich domain-containing protein,is induced by viral infection and antagonizes interferon(IFN)production,thereby facilitating viral replication.This study not only demonstrates a direct link between Rubicon and NF-κB essential modulator(NEMO),but also demonstrates how the interaction between Rubicon and NEMO inhibits the production of type I interferon.This study shows a previously unrecognized function of Rubicon as an important negative regulator of the innate immune response. 展开更多
关键词 thereby MODULATOR response.
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