Dear Editor,In recent years,there is growing interest regarding the roles of senescent bone marrow(BM)microenvironment in the initiation of leukemia.Aged mice transplanted with AML1-ETO(AML1-ETO fusion protein)-positi...Dear Editor,In recent years,there is growing interest regarding the roles of senescent bone marrow(BM)microenvironment in the initiation of leukemia.Aged mice transplanted with AML1-ETO(AML1-ETO fusion protein)-positive hematopoietic stem cells(HSCs)present with a significant increase in the frequency of AMLETO-positive early progenitor cells in BM as well as an in crease of immature myeloid cells compared to young recipients(Vas et aL,2012).BM mesenchymal stem cells(MSCs)from myelodysplastic syndromes(MDS)animal models and MDS patients exhibit impaired proliferation and differentiation potentials,abnormal cytoki ne secretion,and dysregulated gene expression profile(Lopez-Villar et al.,2009;Geyh et al.,2013;Mattiucci et al.,2018).However,the causal relationship between senes・cent BM microenvironment and leukemia development is unclear.Whether senes・cent BM microenvironment initiates or accelerates leukemia development remains unknown.展开更多
基金Supplementary material is available at Journal of Molecular Cell Biology online.This work was supported by grants from the National Natural Science Foundation of Chino(81925002,81970099,and 31900814)the Strategic Priority Research Program of Chinese Academy of Sciences(XDA16010601)+3 种基金the Key Research Development Program of Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory)(2018GZR110104006)the Science and Technology Planning Project of Guangdong Province(2017BO 30314056 and 2017B020230004)the CAS Key Research Program of Frontier Sciences(QYZDB.SSW.SMC057)the Health and Medical Core Collaborative Innovation Program of Guangzhou Scientific and Technology(201803040017).
文摘Dear Editor,In recent years,there is growing interest regarding the roles of senescent bone marrow(BM)microenvironment in the initiation of leukemia.Aged mice transplanted with AML1-ETO(AML1-ETO fusion protein)-positive hematopoietic stem cells(HSCs)present with a significant increase in the frequency of AMLETO-positive early progenitor cells in BM as well as an in crease of immature myeloid cells compared to young recipients(Vas et aL,2012).BM mesenchymal stem cells(MSCs)from myelodysplastic syndromes(MDS)animal models and MDS patients exhibit impaired proliferation and differentiation potentials,abnormal cytoki ne secretion,and dysregulated gene expression profile(Lopez-Villar et al.,2009;Geyh et al.,2013;Mattiucci et al.,2018).However,the causal relationship between senes・cent BM microenvironment and leukemia development is unclear.Whether senes・cent BM microenvironment initiates or accelerates leukemia development remains unknown.
