Introduction COVID-19,caused by SARS-CoV-2,is a highly contagious disease.1 By April 8,2020,more than 1,350,000 patients were diagnosed with COVID-19 globally,with more than 79,000 deaths worldwide attributable to the...Introduction COVID-19,caused by SARS-CoV-2,is a highly contagious disease.1 By April 8,2020,more than 1,350,000 patients were diagnosed with COVID-19 globally,with more than 79,000 deaths worldwide attributable to the disease.2 Recent clinical data reported that mild and critical patients manifested different symptoms.Most of the mild patients with COVID-19 had symptoms such as fever,cough,and mild pneumonia,whereas the critical cases presented dyspnea,respiratory failure,sepsis,organ dysfunction,and even eventual death.展开更多
Three new with anolides,daturaselines A-C(1-3),and three new with anolides glycosides,daturasesides A-C(4-6),were isolated and identified from ethyl acetate-soluble fraction of ethanol extract of Datura metel seeds.Th...Three new with anolides,daturaselines A-C(1-3),and three new with anolides glycosides,daturasesides A-C(4-6),were isolated and identified from ethyl acetate-soluble fraction of ethanol extract of Datura metel seeds.The structures of new compounds were established according to the 1D and 2D NMR spectra,combined with high resolution展开更多
基金We thank the patients,nurses,and physicians who pro-vided care for the patients,and the investigators at the Third People's Hospital of Shenzhen.This work is supported by grants from the Science and Technology Innovation Committee of Shenzhen Municipality(202002073000001)National Key Research and Development Program(2020YFC0841700)+1 种基金High-level University Fund(no.G02386301,G02386401)Guangdong Natural Science Foundation Joint Fund(no.2019A1515111038).
文摘Introduction COVID-19,caused by SARS-CoV-2,is a highly contagious disease.1 By April 8,2020,more than 1,350,000 patients were diagnosed with COVID-19 globally,with more than 79,000 deaths worldwide attributable to the disease.2 Recent clinical data reported that mild and critical patients manifested different symptoms.Most of the mild patients with COVID-19 had symptoms such as fever,cough,and mild pneumonia,whereas the critical cases presented dyspnea,respiratory failure,sepsis,organ dysfunction,and even eventual death.
基金Major State BasicResearch Development Program(973 Program)of China(2013CB531801)Chang Jiang Scholar Candidates Programme for Provincial Universities in Heilongjiang(2013CJHB00)
文摘Three new with anolides,daturaselines A-C(1-3),and three new with anolides glycosides,daturasesides A-C(4-6),were isolated and identified from ethyl acetate-soluble fraction of ethanol extract of Datura metel seeds.The structures of new compounds were established according to the 1D and 2D NMR spectra,combined with high resolution
