The chirality-induced spin selectivity(CISS)has been found in the antiferromagnetic and paramagnetic chiral inorganic materials with unpaired electrons,while rarely reported in the spin-paired diamagnetic inorganic ma...The chirality-induced spin selectivity(CISS)has been found in the antiferromagnetic and paramagnetic chiral inorganic materials with unpaired electrons,while rarely reported in the spin-paired diamagnetic inorganic materials with spin-pairing energy.Here,we report the CISS in the spin-paired diamagnetic BiOBr endowed with three levels of chiral mesostructures.Chiral mesostructured BiOBr films(CMBFs)were fabricated through a sugar alcohol-induced hydrothermal route.The antipodal CMBFs exhibited chirality-dependent,magnetic field-independent magnetic circular dichroism(MCD)signals,which indicates the existence of spin selectivity.The spin selectivity of CMBFs was speculated to be the result of the competing effect between the externally applied magnetic field and the effective magnetic field arisen from the spin electron motions in chiral potential.The chirality-induced effective magnetic field acts on the magnetic moment of electrons,potentially overcoming the spin-pairing energy and producing opposite energy changes for spin-down and spin-up electrons.展开更多
Human genome encodes six paralogous gasdermin genes:GSDMA,GSDMB,GSDMC,GSDMD,GSDME and DFNB59.1 Proteolytic cleavage of these gasdermin proteins liberates an N-terminal(NT)fragment from autoinhibition,which assembles i...Human genome encodes six paralogous gasdermin genes:GSDMA,GSDMB,GSDMC,GSDMD,GSDME and DFNB59.1 Proteolytic cleavage of these gasdermin proteins liberates an N-terminal(NT)fragment from autoinhibition,which assembles in membrane to form pores and execute pyroptotic cell death in general.1 In contrast to other gasdermins,gasdermin B(GSDMB)is the only gasdermin gene that has not been identified in rodents.Zhou et al first shed light on the molecular mechanism by which cytotoxic lymphocyte-derived granzyme A(GZMA)cleaves GSDMB to execute pyroptosis in GSDMB-positive cells,especially in cancer cells.2 In this issue of Cell,Hansen et al reported a dynamic host pathogen S.flexneri prevents GSDMB-mediated lysis by secreting IpaH7.8,which targets and ubiquitinates GSDMB for 26S proteasome destruction.3 They showed that GSDMB implements bacteriocidic ability by recognition of the phospholipids on Gram-negative bacterial membranes rather than lysing host cells.Although their experimental design and data are clearly presented and straightforward,there are still some doubts to be clarified.展开更多
基金supported by the National Key R&D Program of China(No.2021YFA1200300)the National Natural Science Foundation of China(Nos.21931008,21975184,21873072,and 21922304)the scientific foundation of the Shanghai Municipal Science and Technology Commission(Nos.19JC1410300).
文摘The chirality-induced spin selectivity(CISS)has been found in the antiferromagnetic and paramagnetic chiral inorganic materials with unpaired electrons,while rarely reported in the spin-paired diamagnetic inorganic materials with spin-pairing energy.Here,we report the CISS in the spin-paired diamagnetic BiOBr endowed with three levels of chiral mesostructures.Chiral mesostructured BiOBr films(CMBFs)were fabricated through a sugar alcohol-induced hydrothermal route.The antipodal CMBFs exhibited chirality-dependent,magnetic field-independent magnetic circular dichroism(MCD)signals,which indicates the existence of spin selectivity.The spin selectivity of CMBFs was speculated to be the result of the competing effect between the externally applied magnetic field and the effective magnetic field arisen from the spin electron motions in chiral potential.The chirality-induced effective magnetic field acts on the magnetic moment of electrons,potentially overcoming the spin-pairing energy and producing opposite energy changes for spin-down and spin-up electrons.
基金The work was supported by the National Natural Science Foundation of China(No.82072223)Scientific Research Foundation of Graduate School of Southeast University(No.YBPY2172)+1 种基金333 High Level Talents Training Project of Jiangsu Province(No.BRA2019011)General Project of Military Logistics Research(No.CLB19J025).
文摘Human genome encodes six paralogous gasdermin genes:GSDMA,GSDMB,GSDMC,GSDMD,GSDME and DFNB59.1 Proteolytic cleavage of these gasdermin proteins liberates an N-terminal(NT)fragment from autoinhibition,which assembles in membrane to form pores and execute pyroptotic cell death in general.1 In contrast to other gasdermins,gasdermin B(GSDMB)is the only gasdermin gene that has not been identified in rodents.Zhou et al first shed light on the molecular mechanism by which cytotoxic lymphocyte-derived granzyme A(GZMA)cleaves GSDMB to execute pyroptosis in GSDMB-positive cells,especially in cancer cells.2 In this issue of Cell,Hansen et al reported a dynamic host pathogen S.flexneri prevents GSDMB-mediated lysis by secreting IpaH7.8,which targets and ubiquitinates GSDMB for 26S proteasome destruction.3 They showed that GSDMB implements bacteriocidic ability by recognition of the phospholipids on Gram-negative bacterial membranes rather than lysing host cells.Although their experimental design and data are clearly presented and straightforward,there are still some doubts to be clarified.
