目的:探讨六味地黄汤加减联合超皮秒激光治疗稳定期黄褐斑临床效果观察。方法:将笔者医院2021年2月-2022年1月收治的86例稳定期肝肾阴虚型黄褐斑患者,按数字表法随机分为对照组42例和研究组44例。对照组给予口服维生素C、E和Q开关Nd∶YA...目的:探讨六味地黄汤加减联合超皮秒激光治疗稳定期黄褐斑临床效果观察。方法:将笔者医院2021年2月-2022年1月收治的86例稳定期肝肾阴虚型黄褐斑患者,按数字表法随机分为对照组42例和研究组44例。对照组给予口服维生素C、E和Q开关Nd∶YAG激光治疗,观察组给予六味地黄汤加减联合超皮秒激光治疗,比较两组治疗3个月后的治疗有效率、黄褐斑面积和严重指数评分(Melasma area severity index,MASI)、中医证候积分、生活质量及安全性。结果:治疗3个月后,研究组治疗有效率86.36%,显著高于对照组的66.67%(P<0.05);治疗1个月后、治疗3个月后,两组MASI评分均较治疗前明显降低,且研究组MASI评分均显著低于对照组(P<0.05);治疗3个月后,两组各项中医证候积分均较治疗前明显降低,且研究组各项中医证候积分均显著低于对照组(P<0.05);治疗3个月后,两组黄褐斑生活质量评分(MELA-subjective quality of life,MELA-SQOL)、皮肤病生活质量指数(Dermatology life quality index,DLQI)均较治疗前明显降低,且研究组MELASQOL、DLQI评分均显著低于对照组(P<0.05);两组不良反应发生情况差异无统计学意义。结论:六味地黄汤加减联合超皮秒激光治疗稳定期黄褐斑疗效显著,该联合疗法能有效改善患者的皮损程度和生活质量,安全性高,值得临床推广应用。展开更多
[Objective] This trial was to investigate the effect of dietary Picria felterrae Lour extracts on serum biochemical indexes and immune function of Guangxi Partridge chickens. [Method] Totally 500 individuals of 1-day-...[Objective] This trial was to investigate the effect of dietary Picria felterrae Lour extracts on serum biochemical indexes and immune function of Guangxi Partridge chickens. [Method] Totally 500 individuals of 1-day-old Guangxi Partridge chickens were randomly divided into five groups, five replicates each group and 20 chicks each replicate. Groups A, B and C were treatment groups supplemented with 0.70%, 0.35% and0.175% P. felterrae extracts in the basal diet, respectively; group D was a medical control group supplemented with 0.01% colistin sulfate premix in the basal diet; and group E was a control group with basal diet. Serum samples were collected from 10 chickens in each group at 21, 35 and 49 days of age, to analyze the biochemical and immune indexes. [Result] It had no significant impact on serum TP and GLU contents of chickens by adding different levels of P. felterrae extracts in the basal diet（P 〉0.05）. However, at 21 and 35 days of age, the TBILI content of chickens in groups A, B and C were extremely lower or significantly lower than that in group E（ P〈0.01; P〈0.05）. At 35 days of age, the serum AKP activities in groups A, B and C were extremely higher than that in group E（P〈0.01）, and the serum GOT activities at 21 and 35 days of age in group C were significantly higher than that in group E（P〈0.05）. At 49 days of age, the serum Ig G content in groups A, B and C and the IL-2 content in group B and group C were significantly lower or extremely lower than that in group E（ P〈0.05; P〈0.01）; the T-AOC content in group B was significantly higher than that in group E（P〈0.05）; the GSH content in groups A, B and C were significantly higher than that in group E（ P〈0.05）. Adding different levels of P. felterrae extracts in the diet significantly decreased the TBILI content, reduced the Ig G, IL-2 and IL-6 contents, and improved the AKP and GOT activities and the T-AOC and GSH contents of Guangxi Partridge chicken. [Conclusion] Adding 0.35% P. felterrae extracts in the basal diet received the best effort.展开更多
文摘目的:探讨六味地黄汤加减联合超皮秒激光治疗稳定期黄褐斑临床效果观察。方法:将笔者医院2021年2月-2022年1月收治的86例稳定期肝肾阴虚型黄褐斑患者,按数字表法随机分为对照组42例和研究组44例。对照组给予口服维生素C、E和Q开关Nd∶YAG激光治疗,观察组给予六味地黄汤加减联合超皮秒激光治疗,比较两组治疗3个月后的治疗有效率、黄褐斑面积和严重指数评分(Melasma area severity index,MASI)、中医证候积分、生活质量及安全性。结果:治疗3个月后,研究组治疗有效率86.36%,显著高于对照组的66.67%(P<0.05);治疗1个月后、治疗3个月后,两组MASI评分均较治疗前明显降低,且研究组MASI评分均显著低于对照组(P<0.05);治疗3个月后,两组各项中医证候积分均较治疗前明显降低,且研究组各项中医证候积分均显著低于对照组(P<0.05);治疗3个月后,两组黄褐斑生活质量评分(MELA-subjective quality of life,MELA-SQOL)、皮肤病生活质量指数(Dermatology life quality index,DLQI)均较治疗前明显降低,且研究组MELASQOL、DLQI评分均显著低于对照组(P<0.05);两组不良反应发生情况差异无统计学意义。结论:六味地黄汤加减联合超皮秒激光治疗稳定期黄褐斑疗效显著,该联合疗法能有效改善患者的皮损程度和生活质量,安全性高,值得临床推广应用。
基金Supported by Science and Technology Development Program of Nanning City(20155181)Key Technology Research and Development Program of Guangxi Province(14121003-3-3)
文摘[Objective] This trial was to investigate the effect of dietary Picria felterrae Lour extracts on serum biochemical indexes and immune function of Guangxi Partridge chickens. [Method] Totally 500 individuals of 1-day-old Guangxi Partridge chickens were randomly divided into five groups, five replicates each group and 20 chicks each replicate. Groups A, B and C were treatment groups supplemented with 0.70%, 0.35% and0.175% P. felterrae extracts in the basal diet, respectively; group D was a medical control group supplemented with 0.01% colistin sulfate premix in the basal diet; and group E was a control group with basal diet. Serum samples were collected from 10 chickens in each group at 21, 35 and 49 days of age, to analyze the biochemical and immune indexes. [Result] It had no significant impact on serum TP and GLU contents of chickens by adding different levels of P. felterrae extracts in the basal diet（P 〉0.05）. However, at 21 and 35 days of age, the TBILI content of chickens in groups A, B and C were extremely lower or significantly lower than that in group E（ P〈0.01; P〈0.05）. At 35 days of age, the serum AKP activities in groups A, B and C were extremely higher than that in group E（P〈0.01）, and the serum GOT activities at 21 and 35 days of age in group C were significantly higher than that in group E（P〈0.05）. At 49 days of age, the serum Ig G content in groups A, B and C and the IL-2 content in group B and group C were significantly lower or extremely lower than that in group E（ P〈0.05; P〈0.01）; the T-AOC content in group B was significantly higher than that in group E（P〈0.05）; the GSH content in groups A, B and C were significantly higher than that in group E（ P〈0.05）. Adding different levels of P. felterrae extracts in the diet significantly decreased the TBILI content, reduced the Ig G, IL-2 and IL-6 contents, and improved the AKP and GOT activities and the T-AOC and GSH contents of Guangxi Partridge chicken. [Conclusion] Adding 0.35% P. felterrae extracts in the basal diet received the best effort.
