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Dynamic Non-Invasive Detection of NADH Based on Blood Flow-Mediated Skin Fluorescence (FMSF) Method
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作者 peng liu Tengfei Bi +2 位作者 Gongzhi Du Long Yan Huayi Hou 《Open Journal of Applied Sciences》 2024年第6期1437-1453,共17页
Nicotinamide adenine dinucleotide (NADH/NAD+) is involved in important biochemical reactions in human metabolism, including participation in energy production by mitochondria. The changes in fluorescence intensity as ... Nicotinamide adenine dinucleotide (NADH/NAD+) is involved in important biochemical reactions in human metabolism, including participation in energy production by mitochondria. The changes in fluorescence intensity as a function of time in response to blocking and releasing of blood flow in a forearm are used as a measure of oxygen transport with blood to the tissue, which directly correlates with the skin microcirculation status. In this paper, a non-invasive dynamic monitoring system based on blood flow-mediated skin fluorescence (FMSF) technology is developed to monitor the NADH fluorescence intensity of skin tissue during the process of blocking reactive hyperemia. Simultaneously, laser speckle contrast imaging (LSCI) and laser Doppler flowmetry (LDF) were used to observe blood flow, blood oxygen saturation (SOt2) and relative amount of hemoglobin (rHb) during the measurement process, which helped to explore NADH dynamics relevant physiological changes. A variety of parameters have been derived to describe NADH fluorescence curve based on the FMSF device. The experimental results are conducive to understanding the NADH measurement and the physiological processes related to it, which help FMSF to be a great avenue for in vivo physiological, clinical and pharmacological research on mitochondrial metabolism. 展开更多
关键词 Reduced Nicotinamide Adenine Dinucleotide (NADH) Flow-Mediated Skin Fluorescence (FMSF) Laser Doppler Flowmetry (LDF) Blood Flow
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教育数字化转型背景下在线开放课程发展研究
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作者 张策 初佃辉 +2 位作者 刘鹏 魏萌 王宇彬 《中国教育信息化》 2024年第9期97-107,共11页
信息技术持续推动人类社会迈向数字时代,全球范围内数字化建设方兴未艾,世界高等教育数字化转型深入发展,以慕课为代表的在线开放课程正在重塑。通过回顾中国慕课十年发展成就,从六个维度阐述中国慕课作为中国高等教育的对外交流展示名... 信息技术持续推动人类社会迈向数字时代,全球范围内数字化建设方兴未艾,世界高等教育数字化转型深入发展,以慕课为代表的在线开放课程正在重塑。通过回顾中国慕课十年发展成就,从六个维度阐述中国慕课作为中国高等教育的对外交流展示名片,继而从名师课程开放、优质资源共享、教学模式创新、跨地域网络教研和深化教学改革角度论述中国慕课创造的世界性先例。针对数字化转型时代背景,聚焦信息技术赋能教育教学、保持慕课开放融合特质、支持专业建设与专业人才培养三个方面,分析数字化转型背景下在线开放课程发展趋向,着重针对人工智能与元宇宙对数字化教学变革的驱动,重点论述二者对在线开放课程的重构,并对慕课与人工智能式在线课程、慕课与元宇宙式在线课程进行了比较分析。在此基础上,从慕课特质角度,分析在线开放课程在高等教育数字化转型中所处的地位,强调在线开放课程的头部引领作用。据此提出,面向未来,教育工作者要勇于拥抱技术赋能教育教学的数字变革时代,推动在线开放课程在迎接数字化转型全球浪潮的洗礼中创新求变、迭变升级。 展开更多
关键词 数字化转型 在线开放课程 慕课 人工智能 元宇宙
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Water and nitrogen footprint assessment of integrated agronomic practice management in a summer maize cropping system
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作者 Ningning Yu Bingshuo Wang +3 位作者 Baizhao Ren Bin Zhao peng liu Jiwang Zhang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第10期3610-3621,共12页
The footprints of water and nitrogen(WF and NF)provide a comprehensive overview of the type and quantity of water consumption and reactive nitrogen(Nr)loss in crop production.In this study,a field experiment over two ... The footprints of water and nitrogen(WF and NF)provide a comprehensive overview of the type and quantity of water consumption and reactive nitrogen(Nr)loss in crop production.In this study,a field experiment over two years(2019 and 2020)compared three integrated agronomic practice management(IAPM)systems:An improved management system(T2),a high-yield production system(T3),and an integrated soil-crop management system(ISCM)using a local smallholder farmer’s practice system(T1)as control,to investigate the responses of WF,Nr losses,water use efficiency(WUE),and nitrogen use efficiency(NUE)to IAPM.The results showed that IAPM optimized water distribution and promoted water use by summer maize.The evapotranspiration over the whole maize growth period of IAPM increased,but yield increased more,leading to a significant increase in WUE.The WUE of the T2,T3,and ISCM treatments was significantly greater than in the T1 treatment,in 2019 and 2020respectively,by 19.8-21.5,31.8-40.6,and 34.4-44.6%.The lowest WF was found in the ISCM treatment,which was 31.0%lower than that of the T1 treatment.In addition,the ISCM treatment optimized soil total nitrogen(TN)distribution and significantly increased TN in the cultivated layer.Excessive nitrogen fertilizer was applied in treatment T3,producing the highest maize yield,and resulting in the highest Nr losses.In contrast,the ISCM treatment used a reduced nitrogen fertilizer rate,sacrificing grain yield partly,which reduced Nr losses and eventually led to a significant increase in nitrogen use efficiency and nitrogen recovery.The Nr level in the ISCM treatment was34.8%lower than in the T1 treatment while NUE was significantly higher than in the T1 treatment by 56.8-63.1%in2019 and 2020,respectively.Considering yield,WUE,NUE,WF,and NF together,ISCM should be used as a more sustainable and clean system for sustainable production of summer maize. 展开更多
关键词 integrated agronomic practice management water footprints nitrogen footprints water use efficiency nitrogen use efficiency yield
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Near-zero-adhesion-enabled intact wafer-scale resist-transfer printing for high-fidelity nanofabrication on arbitrary substrates
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作者 Zhiwen Shu Bo Feng +5 位作者 peng liu Lei Chen Huikang Liang Yiqin Chen Jianwu Yu Huigao Duan 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2024年第1期313-326,共14页
There is an urgent need for novel processes that can integrate different functional nanostructures onto specific substrates,so as to meet the fast-growing need for broad applications in nanoelectronics,nanophotonics,a... There is an urgent need for novel processes that can integrate different functional nanostructures onto specific substrates,so as to meet the fast-growing need for broad applications in nanoelectronics,nanophotonics,and fexible optoelectronics.Existing direct-lithography methods are difficult to use on fexible,nonplanar,and biocompatible surfaces.Therefore,this fabrication is usually accomplished by nanotransfer printing.However,large-scale integration of multiscale nanostructures with unconventional substrates remains challenging because fabrication yields and quality are often limited by the resolution,uniformity,adhesivity,and integrity of the nanostructures formed by direct transfer.Here,we proposed a resist-based transfer strategy enabled by near-zero adhesion,which was achieved by molecular modification to attain a critical surface energy interval.This approach enabled the intact transfer of wafer-scale,ultrathin-resist nanofilms onto arbitrary substrates with mitigated cracking and wrinkling,thereby facilitating the in situ fabrication of nanostructures for functional devices.Applying this approach,fabrication of three-dimensional-stacked multilayer structures with enhanced functionalities,nanoplasmonic structures with~10 nm resolution,and MoS2-based devices with excellent performance was demonstrated on specific substrates.These results collectively demonstrated the high stability,reliability,and throughput of our strategy for optical and electronic device applications. 展开更多
关键词 resist-based transfer printing near-zero adhesion critical surface energy wafer-scale nanofabrication in situ fabrication optoelectronic devices
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A novel live attenuated vaccine candidate protects chickens against subtype B avian metapneumovirus
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作者 Lingzhai Meng Mengmeng Yu +15 位作者 Suyan Wang Yuntong Chen Yuanling Bao peng liu Xiaoyan Feng Tana He Ru Guo Tao Zhang Mingxue Hu Changjun liu Xiaole Qi Kai Li Li Gao Yanping Zhang Hongyu Cui Yulong Gao 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第5期1658-1670,共13页
Avian metapneumovirus(aMPV) is a highly contagious pathogen that causes acute upper respiratory tract diseases in chickens and turkeys, resulting in serious economic losses. Subtype B aMPV has recently become the domi... Avian metapneumovirus(aMPV) is a highly contagious pathogen that causes acute upper respiratory tract diseases in chickens and turkeys, resulting in serious economic losses. Subtype B aMPV has recently become the dominant epidemic strain in China. We developed an attenuated aMPV subtype B strain by serial passaging in Vero cells and evaluated its safety and efficacy as a vaccine candidate. The safety test showed that after the 30th passage, the LN16-A strain was fully attenuated, as clinical signs of infection and histological lesions were absent after inoculation.The LN16-A strain did not revert to a virulent strain after five serial passages in chickens. The genomic sequence of LN16-A differed from that of the parent wild-type LN16(wtLN16) strain and had nine amino acid mutations. In chickens, a single immunization with LN16-A induced robust humoral and cellular immune responses, including the abundant production of neutralizing antibodies, CD4^(+) T lymphocytes, and the Th1(IFN-γ) and Th2(IL-4 and IL-6)cytokines. We also confirmed that LN16-A provided 100% protection against subtype B aMPV and significantly reduced viral shedding and turbinate inflammation. Our findings suggest that the LN16-A strain is a promising live attenuated vaccine candidate that can prevent infection with subtype B aMPV. 展开更多
关键词 avian metapneumovirus ATTENUATED protection vaccine candidate CHICKENS
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Population genomic analysis reveals key genetic variations and the driving force for embryonic callus induction capability in maize
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作者 peng liu Langlang Ma +8 位作者 Siyi Jian Yao He Guangsheng Yuan Fei Ge Zhong Chen Chaoying Zou Guangtang Pan Thomas Lübberstedt Yaou Shen 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第7期2178-2195,共18页
Genetic transformation has been an effective technology for improving the agronomic traits of maize.However,it is highly reliant on the use of embryonic callus(EC)and shows a serious genotype dependence.In this study,... Genetic transformation has been an effective technology for improving the agronomic traits of maize.However,it is highly reliant on the use of embryonic callus(EC)and shows a serious genotype dependence.In this study,we performed genomic sequencing for 80 core maize germplasms and constructed a high-density genomic variation map using our newly developed pipeline(MQ2Gpipe).Based on the induction rate of EC(REC),these inbred lines were categorized into three subpopulations.The low-REC germplasms displayed more abundant genetic diversity than the high-REC germplasms.By integrating a genome-wide selective signature screen and region-based association analysis,we revealed 95.23 Mb of selective regions and 43 REC-associated variants.These variants had phenotypic variance explained values ranging between 21.46 and 49.46%.In total,103 candidate genes were identified within the linkage disequilibrium regions of these REC-associated loci.These genes mainly participate in regulation of the cell cycle,regulation of cytokinesis,and other functions,among which MYB15 and EMB2745 were located within the previously reported QTL for EC induction.Numerous leaf area-associated variants with large effects were closely linked to several REC-related loci,implying a potential synergistic selection of REC and leaf size during modern maize breeding. 展开更多
关键词 MAIZE genetic transformation embryonic callus selective signal association analysis
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SFNet:Stellar Feature Network with CWT for Stellar Spectra Recognition
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作者 Hao Fu peng liu +1 位作者 Xuan Qi Xue Mei 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2024年第9期260-270,共11页
Stellar spectral classification is crucial in astronomical data analysis.However,existing studies are often limited by the uneven distribution of stellar samples,posing challenges in practical applications.Even when b... Stellar spectral classification is crucial in astronomical data analysis.However,existing studies are often limited by the uneven distribution of stellar samples,posing challenges in practical applications.Even when balancing stellar categories and their numbers,there is room for improvement in classification accuracy.This study introduces a Continuous Wavelet Transform using the Super Morlet wavelet to convert stellar spectra into wavelet images.A novel neural network,the Stellar Feature Network,is proposed for classifying these images.Stellar spectra from Large Sky Area Multi-Object Fiber Spectroscopic Telescope DR9,encompassing five equal categories(B,A,F,G,K),were used.Comparative experiments validate the effectiveness of the proposed methods and network,achieving significant improvements in classification accuracy. 展开更多
关键词 methods data analysis-techniques image processing-stars imaging-galaxies stellar content
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Comprehensive insights into recent innovations:Magnesium-inclusive high-entropy alloys
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作者 Andrii Babenko Ehsan Ghasali +6 位作者 Saleem Raza Kahila Baghchesaraee Ye Cheng Asif Hayat peng liu Shuaifei Zhao Yasin Orooji 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2024年第4期1311-1345,共35页
This review focuses on thermodynamic and physical parameters,synthesis methods,and reported phases of Magnesium(Mg)containing high-entropy alloys(HEAs).Statistical data of publications concerning Mg-containing HEAs we... This review focuses on thermodynamic and physical parameters,synthesis methods,and reported phases of Magnesium(Mg)containing high-entropy alloys(HEAs).Statistical data of publications concerning Mg-containing HEAs were collected and analyzed.Data on the chemical elements included in Mg-containing HEAs,their theoretical end experimental densities,thermodynamic parameters,physical parameters,fabricated techniques and reported phases were also collected and discussed.On the basis of this information,a new classification for HEAs was proposed.It is also shown that the existing thermodynamic parameters cannot accurately predict the formation of a single phase solid solution for Mg-containing HEAs.The physical parameters of Mg-containing HEAs are within a wide range,and most of the synthesized Mg-containing HEAs have a complex multiphase structure. 展开更多
关键词 MAGNESIUM High-entropy alloys CLASSIFICATION Thermodynamic parameters Physical parameters
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Development and validation of a nomogram model for predicting the risk of gallstone recurrence after gallbladder-preserving surgery
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作者 peng liu Yong-Wei Chen +5 位作者 Che liu Yin-Tao Wu Wen-Chao Zhao Jian-Yong Zhu Yang An Nian-Xin Xia 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2024年第3期288-292,共5页
Background:The high incidence of gallstone recurrence was a major concern for laparoscopic gallbladderpreserving surgery.This study aimed to investigate the risk factors for gallstone recurrence after gallbladder-pres... Background:The high incidence of gallstone recurrence was a major concern for laparoscopic gallbladderpreserving surgery.This study aimed to investigate the risk factors for gallstone recurrence after gallbladder-preserving surgery and to establish an individualized nomogram model to predict the risk of gallstone recurrence.Methods:The clinicopathological and follow-up data of 183 patients who were initially diagnosed with gallstones and treated with gallbladder-preserving surgery at our hospital from January 2012 to January 2019 were retrospectively collected.The independent predictive factors for gallstone recurrence following gallbladder-preserving surgery were identified by multivariate logistic regression analysis.A nomogram model for the prediction of gallstone recurrence was constructed based on the selected variables.The C-index,receiver operating characteristic(ROC)curve and calibration curve were used to evaluate the predictive power of the nomogram model for gallstone recurrence.Results:During the follow-up period,a total of 65 patients experienced gallstone recurrence,and the recurrence rate was 35.5%.Multivariate logistic regression analysis revealed that the course of gallstones>2 years[odds ratio(OR)=2.567,95%confidence interval(CI):1.270-5.187,P=0.009],symptomatic gallstones(OR=2.589,95%CI:1.059-6.329,P=0.037),multiple gallstones(OR=2.436,95%CI:1.133-5.237,P=0.023),history of acute cholecystitis(OR=2.778,95%CI:1.178-6.549,P=0.020)and a greasy diet(OR=2.319,95%CI:1.186-4.535,P=0.014)were independent risk factors for gallstone recurrence after gallbladder-preserving surgery.A nomogram model for predicting the recurrence of gallstones was established based on the above five variables.The results showed that the C-index of the nomogram model was 0.692,suggesting it was valuable to predict gallstone recurrence.Moreover,the calibration curve showed good consistency between the predicted probability and actual probability.Conclusions:The nomogram model for the prediction of gallstone recurrence might help clinicians develop a proper treatment strategy for patients with gallstones.Gallbladder-preserving surgery should be cautiously considered for patients with high recurrence risks. 展开更多
关键词 GALLSTONE Gallbladder-preserving surgery RECURRENCE Risk factors NOMOGRAM
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The environment,especially the minimum temperature,affects summer maize grain yield by regulating ear differentiation and grain development
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作者 Jing Chen Baizhao Ren +2 位作者 Bin Zhao peng liu Jiwang Zhang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第7期2227-2241,共15页
Ear differentiation,grain development and their interaction with factors in the growing environment,such as temperature,solar radiation and precipitation,greatly influence grain number and grain weight,and ultimately ... Ear differentiation,grain development and their interaction with factors in the growing environment,such as temperature,solar radiation and precipitation,greatly influence grain number and grain weight,and ultimately affect summer maize production.In this study,field experiments involving different sowing dates were conducted over three years to evaluate the effects of temperature factors,average solar radiation and total precipitation on the growth process,ear differentiation,fertilization characteristics,grain filling and yield of summer maize varieties with different growth durations.Four hybrids were evaluated in Huang-Huai-Hai Plain(HHHP),China from 2018 to 2020 with five different sowing dates.The results showed that the grain yield formation of summer maize was strongly impacted by the environment from the silking(R1)to milking(R3)stage.Average minimum temperature(AT_(min))was the key environmental factor that determined yield.Reductions in the length of the growing season(r=–0.556,P<0.01)and the total floret number on ear(R^(2)=0.200,P<0.001)were found when AT_(min) was elevated from the emerging(VE)to R1 stage.Both grain-filling rate(R^(2)=0.520,P<0.001)and the floret abortion rate on ear(R^(2)=0.437,P<0.001)showed quadratic relationships with AT_(min) from the R1 to physiological maturity(R6)stage,while the number of days after the R1 stage(r=–0.756,P<0.01)was negatively correlated with AT_(min).An increase in AT_(min) was beneficial for the promotion of yield when it did not exceeded a certain level(above 23°C during the R1–R3 stage and 20–21°C during the R1-R6 stage).Enhanced solar radiation and precipitation during R1–R6 increased the grain-filling rate(R^(2)=0.562,P<0.001 and R^(2)=0.229,P<0.05,respectively).Compared with short-season hybrids,full-season hybrids showed much greater suitability for a critical environment.The coordinated regulation of AT_(min),ear differentiation and grain development at the pre-and post-silking stages improved maize yield by increasing total floret number and grain-filling rate,and by reducing the floret abortion rate on ear. 展开更多
关键词 sowing date hybrid maturity growing environment ear differentiation and grain development
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Boosted Electrocatalytic Glucose Oxidation Reaction on Noble-Metal-Free MoO_(3)-Decorated Carbon Nanotubes
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作者 Yu-Long Men Ning Dou +3 位作者 Yiyi Zhao Yan Huang Lei Zhang peng liu 《Transactions of Tianjin University》 EI CAS 2024年第1期63-73,共11页
Electrocatalytic glucose oxidation reaction(GOR)has attracted much attention owing to its crucial role in biofuel cell fabrication.Herein,we load MoO_(3)nanoparticles on carbon nanotubes(CNTs)and use a discharge proce... Electrocatalytic glucose oxidation reaction(GOR)has attracted much attention owing to its crucial role in biofuel cell fabrication.Herein,we load MoO_(3)nanoparticles on carbon nanotubes(CNTs)and use a discharge process to prepare a noblemetal-free MC-60 catalyst containing MoO_(3),Mo_(2)C,and a Mo_(2)C–MoO_(3)interface.In the GOR,MC-60 shows activity as high as 745μA/(mmol/L cm^(2)),considerably higher than those of the Pt/CNT(270μA/(mmol/L cm^(2)))and Au/CNT catalysts(110μA/(mmol/L cm^(2))).In the GOR,the response minimum on MC-60 is as low as 8μmol/L,with a steady-state response time of only 3 s.Moreover,MC-60 has superior stability and anti-interference ability to impurities in the GOR.The better performance of MC-60 in the GOR is attributed to the abundant Mo sites bonding to C and O atoms at the MoO_(3)–Mo_(2)C interface.These Mo sites create active sites for promoting glucose adsorption and oxidation,enhancing MC-60 performance in the GOR.Thus,these results help to fabricate more effi cient noble-metal-free catalysts for the fabrication of glucose-based biofuel cells. 展开更多
关键词 Interface eff ect ELECTROCATALYSIS Molybdenum oxide GLUCOSE Oxidation reaction
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Modulating charge separation and transfer for high-performance photoelectrodes via built-in electric field
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作者 Houyan Cheng peng liu +3 位作者 Yuntao Cui Ru Ya Yuxiang Hu Jinshu Wang 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第5期1126-1146,共21页
Constructing a built-in electric field has emerged as a key strategy for enhancing charge separation and transfer,thereby improving photoelectrochemical performance.Recently,considerable efforts have been devoted to t... Constructing a built-in electric field has emerged as a key strategy for enhancing charge separation and transfer,thereby improving photoelectrochemical performance.Recently,considerable efforts have been devoted to this endeavor.This review systematically summarizes the impact of built-in electric fields on enhancing charge separation and transfer mechanisms,focusing on the modulation of built-in electric fields in terms of depth and orderliness.First,mechanisms and tuning strategies for built-in electric fields are explored.Then,the state-of-the-art works regarding built-in electric fields for modulating charge separation and transfer are summarized and categorized according to surface and interface depth.Finally,current strategies for constructing bulk built-in electric fields in photoelectrodes are explored,and insights into future developments for enhancing charge separation and transfer in high-performance photoelectrochemical applications are provided. 展开更多
关键词 photoelectrochemical water splitting bulk built-in electric field cation intercalation charge separation and transfer
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Not in Control,but Liable?Attributing Human Responsibility for Fully Automated Vehicle Accidents
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作者 Siming Zhai Lin Wang peng liu 《Engineering》 SCIE EI CAS CSCD 2024年第2期121-132,共12页
Human agency has become increasingly limited in complex systems with increasingly automated decision-making capabilities.For instance,human occupants are passengers and do not have direct vehicle control in fully auto... Human agency has become increasingly limited in complex systems with increasingly automated decision-making capabilities.For instance,human occupants are passengers and do not have direct vehicle control in fully automated cars(i.e.,driverless cars).An interesting question is whether users are responsible for the accidents of these cars.Normative ethical and legal analyses frequently argue that individuals should not bear responsibility for harm beyond their control.Here,we consider human judgment of responsibility for accidents involving fully automated cars through three studies with seven experiments(N=2668).We compared the responsibility attributed to the occupants in three conditions:an owner in his private fully automated car,a passenger in a driverless robotaxi,and a passenger in a conventional taxi,where none of these three occupants have direct vehicle control over the involved vehicles that cause identical pedestrian injury.In contrast to normative analyses,we show that the occupants of driverless cars(private cars and robotaxis)are attributed more responsibility than conventional taxi passengers.This dilemma is robust across different contexts(e.g.,participants from China vs the Republic of Korea,participants with first-vs third-person perspectives,and occupant presence vs absence).Furthermore,we observe that this is not due to the perception that these occupants have greater control over driving but because they are more expected to foresee the potential consequences of using driverless cars.Our findings suggest that when driverless vehicles(private cars and taxis)cause harm,their users may face more social pressure,which public discourse and legal regulations should manage appropriately. 展开更多
关键词 Fully automated vehicle accidents Responsibility attribution CONTROLLABILITY Foreseeability
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Chlorfenapyr poisoning:mechanisms,clinical presentations,and treatment strategies
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作者 Ji Cheng Yulu Chen +4 位作者 Weidong Wang Xueqi Zhu Zhenluo Jiang peng liu Liwen Du 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2024年第3期214-219,共6页
BACKGROUND:Chlorfenapyr is used to kill insects that are resistant to organophosphorus insecticides.Chlorfenapyr poisoning has a high mortality rate and is difficult to treat.This article aims to review the mechanisms... BACKGROUND:Chlorfenapyr is used to kill insects that are resistant to organophosphorus insecticides.Chlorfenapyr poisoning has a high mortality rate and is difficult to treat.This article aims to review the mechanisms,clinical presentations,and treatment strategies for chlorfenapyr poisoning.DATA RESOURCES:We conducted a review of the literature using PubMed,Web of Science,and SpringerLink from their beginnings to the end of October 2023.The inclusion criteria were systematic reviews,clinical guidelines,retrospective studies,and case reports on chlorfenapyr poisoning that focused on its mechanisms,clinical presentations,and treatment strategies.The references in the included studies were also examined to identify additional sources.RESULTS:We included 57 studies in this review.Chlorfenapyr can be degraded into tralopyril,which is more toxic and reduces energy production by inhibiting the conversion of adenosine diphosphate to adenosine triphosphate.High fever and altered mental status are characteristic clinical presentations of chlorfenapyr poisoning.Once it occurs,respiratory failure occurs immediately,ultimately leading to cardiac arrest and death.Chlorfenapyr poisoning is diflcult to treat,and there is no specific antidote.CONCLUSION:Chlorfenapyr is a new pyrrole pesticide.Although it has been identified as a moderately toxic pesticide by the World Health Organization(WHO),the mortality rate of poisoned patients is extremely high.There is no specific antidote for chlorfenapyr poisoning.Therefore,based on the literature review,future efforts to explore rapid and effective detoxification methods,reconstitute intracellular oxidative phosphorylation couplings,identify early biomarkers of chlorfenapyr poisoning,and block the conversion of chlorfenapyr to tralopyril may be helpful for emergency physicians in the diagnosis and treatment of this disease. 展开更多
关键词 Chlorfenapyr poisoning MECHANISM Clinical presentation TREATMENT
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Icariin ameliorates viral myocarditis by inhibiting TLR4-mediated ferroptosis
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作者 Wei Luo Yi Lu +4 位作者 Jun-Hua Deng peng liu Yan Huang Wan-Xi liu Chun-Li Huang 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2024年第3期106-114,I0002-I0005,共13页
Objective:To explore the mechanism by which icariin alleviates viral myocarditis.Methods:CVB3-induced cardiomyocytes were used as an in vitro model of viral myocarditis to assess the effects of icariin treatment on ce... Objective:To explore the mechanism by which icariin alleviates viral myocarditis.Methods:CVB3-induced cardiomyocytes were used as an in vitro model of viral myocarditis to assess the effects of icariin treatment on cell viability,inflammation,and apoptosis.Moreover,the effects of icariin on ferroptosis and TLR4 signaling were assessed.After AC16 cells were transfected with TLR4 overexpression plasmids,the role of TLR4 in mediating the regulatory effect of icariin in viral myocarditis was investigated.Results:Icariin significantly elevated cell viability and reduced inflammatory factors TNF-α,IL-1β,IL-6,and IL-18.Flow cytometry revealed that icariin decreased apoptosis rate,and the protein expression of Bax and cleaved caspase 3 and 9 in CVB3-induced cardiomyocytes.Additionally,it suppressed ferroptosis including lipid peroxidation and ferrous ion,as well as the TLR4 signaling.However,TLR4 overexpression abrogated the modulatory effects of icariin.Conclusions:Icariin mitigates CVB3-induced myocardial injury by inhibiting TLR4-mediated ferroptosis.Further animal study is needed to verify its efficacy. 展开更多
关键词 Viral myocarditis CVB3 TLR4 Ferroptosis ICARIIN
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Study on the effect of Shixiang plaster on the expression of CD31,serum FN,and VEGF in a rat model with chronic wounds
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作者 Ji Fei Ling-Li Wang +3 位作者 Man liu peng liu Jing-Hua Ruan Kai-Wei Zhang 《Traditional Medicine Research》 2024年第12期31-40,共10页
Background:Chronic wounds pose a significant surgical challenge,often requiring traditional treatments with limited efficacy.This study explores the promising impact of Shixiang plaster,a classic Chinese ointment,on w... Background:Chronic wounds pose a significant surgical challenge,often requiring traditional treatments with limited efficacy.This study explores the promising impact of Shixiang plaster,a classic Chinese ointment,on wound healing.We investigated the cluster of differentiation 31(CD31)expression,serum fibronectin(FN),and vascular endothelial growth factor(VEGF)levels in SPF rats with induced wounds to elucidate the mechanism behind Shixiang plaster’s effectiveness.We investigated the effect and explored the role of Shixiang plaster on the expression of CD31,serum FN,and VEGF in chronic wounds.Methods:The study involved 36 SPF rats divided into model,rb-bFGF,and Shixiang plaster groups.Penicillin was injected into the rats before modelling for 3 days to prevent infection.The skin was excised 2 cm below the horizontal line of the inferior border of the shoulder bone in the middle of the rat column up to the deep fascial layer and inoculated with a certain concentration of Staphylococcus aureus;the wound was covered aseptically for 3 days.The trauma area of the rats was observed at 3,7,and 14 days,respectively.Histopathology was observed using haematoxylin eosin and Masson staining.CD31 expression was detected using immunohistochemistry staining.FN and VEGF expression was detected using serum ELISA.Statistical analyses were carried out by the method of SPSS.Results:Regarding wound morphology,at 3 days,the recovery area of the Shixiang plaster group was larger than that of the other two groups,at 7 days,the wound healing rate of the Shixiang plaster group was significantly higher,and at 14 days,the wounds of the Shixiang plaster group had been mostly healed,with a healing rate of 98.3%.Haematoxylin eosin staining revealed a large amount of granulation tissue at 3 days in the Shixiang plaster group,and the epidermal scales disappeared at 14 days,with thinner epidermal thickness at 1 lesion and a large reduction in inflammatory cell infiltration.Masson staining showed that at 3,7,and 14 days,blue staining was the most abundant and deeper in the Shixiang plaster group,with richer collagen and a compact tissue matrix.Immunohistochemical testing showed strong positive expression of CD31 in the Shixiang plaster group,with abundant neovascularisation and large official lumens extending towards the surface of the wound.Statistically significant elevated expression of FN at 7 and 14 days was determined by ELISA in the Shixiang plaster group,and VEGF expression was significantly increased at 7 days,but expression had been expressed at a low level at 14 days.Conclusion:Shixiang plaster exhibits remarkable efficacy in healing chronic wounds.The proposed mechanism involves FN’s promotion of angiogenesis and cell proliferation,VEGF’s impact on angiogenesis and inflammation,and CD31’s regulatory role in inhibiting inflammation while promoting angiogenesis. 展开更多
关键词 Shixiang plaster chronic wounds CD31 FN VEGF
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荧光“变色龙”——基于动态发光的科普实验方案
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作者 衣梓硕 刘鹏 徐燕 《大学化学》 CAS 2024年第9期304-310,共7页
制备无毒的ZnGa2O4:Bi3+荧光材料,其同时具备可调多色荧光、动态光致变色及热致变色的三模式发光性质。我们利用这种类似“变色龙”的荧光特性设计了三种信息安全实施方案,实验互动性强且具有趣味性,有良好的科普实践展示效果,有助于激... 制备无毒的ZnGa2O4:Bi3+荧光材料,其同时具备可调多色荧光、动态光致变色及热致变色的三模式发光性质。我们利用这种类似“变色龙”的荧光特性设计了三种信息安全实施方案,实验互动性强且具有趣味性,有良好的科普实践展示效果,有助于激发学生对化学学科的学习热情,进而帮助青少年体会“美丽化学”的丰富内涵。 展开更多
关键词 动态荧光 光致变色 热致变色 科普实验 防伪
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Dipeptidyl peptidase-4 inhibitors and the risk of infection: A systematic review and meta-analysis of cardiovascular outcome trials
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作者 Na Yang Li-Yun He +7 位作者 peng liu Zi-Yi Li Yu-Cheng Yang Fan Ping Ling-Ling Xu Wei Li Hua-Bing Zhang Yu-Xiu Li 《World Journal of Diabetes》 SCIE 2024年第5期1011-1020,共10页
BACKGROUND Since adverse events during treatment affect adherence and subsequent glycemic control,understanding the safety profile of oral anti-diabetic drugs is imperative for type 2 diabetes mellitus(T2DM)therapy.AI... BACKGROUND Since adverse events during treatment affect adherence and subsequent glycemic control,understanding the safety profile of oral anti-diabetic drugs is imperative for type 2 diabetes mellitus(T2DM)therapy.AIM To evaluate the risk of infection in patients with T2DM treated with dipeptidyl-peptidase 4(DPP-4)inhibitors.METHODS Electronic databases were searched.The selection criteria included randomized controlled trials focused on cardiovascular outcomes.In these studies,the effects of DPP-4 inhibitors were directly compared to those of either other active anti-diabetic treatments or placebo.Six trials involving 53616 patients were deemed eligible.We calculated aggregate relative risks employing both random-effects and fixed-effects approaches,contingent upon the context.RESULTS The application of DPP-4 inhibitors showed no significant link to the overall infection risk[0.98(0.95,1.02)]or the risk of serious infections[0.96(0.85,1.08)],additionally,no significant associations were found with opportunistic infections[0.69(0.46,1.04)],site-specific infections[respiratory infection 0.99(0.96,1.03),urinary tract infections 1.02(0.95,1.10),abdominal and gastrointestinal infections 1.02(0.83,1.25),skin structure and soft tissue infections 0.81(0.60,1.09),bone infections 0.96(0.68,1.36),and bloodstream infections 0.97(0.80,1.18)].CONCLUSION This meta-analysis of data from cardiovascular outcome trials revealed no heightened infection risk in patients undergoing DPP-4 inhibitor therapy compared to control cohorts. 展开更多
关键词 T2DM DRUGS TREATMENT
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棉花卖给谁:1951年江苏售棉储棉运动中国家提取能力的建构
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作者 彭柳 《中共历史与理论研究》 2024年第1期72-94,225,共24页
1951年在产棉区江苏展开的售棉储棉运动鼓励棉农把存棉卖给国家,在初期开展不利的情况下最终取得了不俗的成绩。本文使用玛格丽特·莱维提出的国家提取能力建构的模型对该事件的走向进行分析,对运动过程中政权与社会的互动变化情况... 1951年在产棉区江苏展开的售棉储棉运动鼓励棉农把存棉卖给国家,在初期开展不利的情况下最终取得了不俗的成绩。本文使用玛格丽特·莱维提出的国家提取能力建构的模型对该事件的走向进行分析,对运动过程中政权与社会的互动变化情况进行梳理,指出国家通过投资提取机构的方式控制市场,最终在与棉农的谈判中取得了优势地位。除了成功提取到足够的棉花,提取机构在运动中的构建与巩固也是需要关注的重点,即运动中的组织建设最终成为提取行为自我强化的一个环节,这在拉长的时空视角下尤为明显。本文还对莱维的分析模型进行了修正,添加了模型变化的动态维度,并从国家建构中的文化论取向角度加以补充。 展开更多
关键词 售棉储棉运动 国家提取能力 国家建构
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基于全直径岩心二维核磁共振测量的低阻油层评价方法
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作者 白莎 石玉江 +5 位作者 李思 淑华 李新 赵建斌 刘鹏 董元媛 《国外测井技术》 2024年第2期32-39,2,共9页
河套盆地临河组砂岩储层中油层类型多样,低阻油层普遍存在,油层识别难度大。本文通过室内柱塞样岩心离心状态、饱和状态测量核磁T谱,结合测井资料及油水分析,明确河套盆地临河组砂岩低阻油层主要成因;根据移动式全直径岩心核磁共振Ti一T... 河套盆地临河组砂岩储层中油层类型多样,低阻油层普遍存在,油层识别难度大。本文通过室内柱塞样岩心离心状态、饱和状态测量核磁T谱,结合测井资料及油水分析,明确河套盆地临河组砂岩低阻油层主要成因;根据移动式全直径岩心核磁共振Ti一T,现场测量数据,分析不同流体组分T1-T,图谱特征,明确典型油层、低阻油层、水层孔隙流体组分分布特征规律,确定二维核磁TI-T,图谱中油水信号的分布特征;同时,根据低阻油信号在二维核磁Ti-T,图谱中的分布特征建立含油饱和度计算模型,实现低阻油层含油性定量评价;形成了基于全直径岩心二维核磁共振测量的低阻油层评价方法,该方法在河套盆地规模化应用,效果显著。 展开更多
关键词 全直径岩心 二维核磁共振 低阻油层 流体识别 含油性定量评价
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