BACKGROUND Erdheim-Chester disease(ECD) is a rare multi-system or multi-organ histiocytic proliferative disease with diverse clinical manifestations, and the development of the disease is complex, which makes clinical...BACKGROUND Erdheim-Chester disease(ECD) is a rare multi-system or multi-organ histiocytic proliferative disease with diverse clinical manifestations, and the development of the disease is complex, which makes clinical diagnosis and treatment difficult.The characteristic clinical manifestations include multi-organ involvement,especially in the symmetrical diaphysis and metaphysis of the bilateral extremities. ECD with a unilateral talus lesion is extremely rare. Here, we report an unusual case of ECD invading the asymmetric talus and tibia without involving other organs. The patient had good outcome after surgery.CASE SUMMARY We report a case of a 67-year-old man who was referred to our outpatient department because of left ankle chronic pain for 5 years, which exacerbated after a foot sprain 6 mo previously. We discovered multiple sclerotic lesions of the tibia and talus on his previous X-ray films, which were initially missed in a local hospital. Therefore, enhanced computer computed tomography(CT) and magnetic resonance imaging were performed. These examinations showed multiple lesions in the bone marrow cavity of the left tibia, and cortical sclerosis and osteonecrosis of the left talus. Specimens were collected via bone puncture from the two lesions, and a final diagnosis of ECD was confirmed by pathological and immunohistochemical examinations. In addition, other auxiliary examinations including head CT, pulmonary CT, spinal CT, abdominal CT,cardiac ultrasound and thyroid ultrasound showed no obvious abnormalities.The patient underwent surgery for the tibia lesion scraping and talus lesion scraping combined with cement casting. The patient started on a progressive rehabilitation at 4 wk, and felt no pain after surgery. During a 2-year follow-up period, the patient exercised normally without pain, and there were no signs of recurrence.CONCLUSION This study shows that surgery treatment may also achieve good results for ECD patients with only bone involvement.展开更多
Epstein-Barr virus(EBV),the first human oncovirus discovered in 1964,has become a focal point in virology,immunology,and oncology because of its unique biological characteristics and significant role in human diseases...Epstein-Barr virus(EBV),the first human oncovirus discovered in 1964,has become a focal point in virology,immunology,and oncology because of its unique biological characteristics and significant role in human diseases.As we commemorate the 60th anniversary of EBV's discovery,it is an opportune moment to reflect on the major advancements in our understanding of this complex virus.In this review,we highlight key milestones in EBV research,including its virion structure and life cycle,interactions with the host immune system,association with EBV-associated diseases,and targeted intervention strategies.展开更多
文摘BACKGROUND Erdheim-Chester disease(ECD) is a rare multi-system or multi-organ histiocytic proliferative disease with diverse clinical manifestations, and the development of the disease is complex, which makes clinical diagnosis and treatment difficult.The characteristic clinical manifestations include multi-organ involvement,especially in the symmetrical diaphysis and metaphysis of the bilateral extremities. ECD with a unilateral talus lesion is extremely rare. Here, we report an unusual case of ECD invading the asymmetric talus and tibia without involving other organs. The patient had good outcome after surgery.CASE SUMMARY We report a case of a 67-year-old man who was referred to our outpatient department because of left ankle chronic pain for 5 years, which exacerbated after a foot sprain 6 mo previously. We discovered multiple sclerotic lesions of the tibia and talus on his previous X-ray films, which were initially missed in a local hospital. Therefore, enhanced computer computed tomography(CT) and magnetic resonance imaging were performed. These examinations showed multiple lesions in the bone marrow cavity of the left tibia, and cortical sclerosis and osteonecrosis of the left talus. Specimens were collected via bone puncture from the two lesions, and a final diagnosis of ECD was confirmed by pathological and immunohistochemical examinations. In addition, other auxiliary examinations including head CT, pulmonary CT, spinal CT, abdominal CT,cardiac ultrasound and thyroid ultrasound showed no obvious abnormalities.The patient underwent surgery for the tibia lesion scraping and talus lesion scraping combined with cement casting. The patient started on a progressive rehabilitation at 4 wk, and felt no pain after surgery. During a 2-year follow-up period, the patient exercised normally without pain, and there were no signs of recurrence.CONCLUSION This study shows that surgery treatment may also achieve good results for ECD patients with only bone involvement.
基金supported by the National Key Research and Development Program of China(2022YFC3400900)the National Natural Science Foundation of China(82030046,82402614)+3 种基金the Postdoctoral Fellowship Program of CPSF(GZB20230886)the Chinese Postdoctoral Science Foundation(2023M743998,2024T171080)Fundamental Research Funds for the Central Universities(24qnpy278)Shenzhen Medical Research Fund(A2302028)。
文摘Epstein-Barr virus(EBV),the first human oncovirus discovered in 1964,has become a focal point in virology,immunology,and oncology because of its unique biological characteristics and significant role in human diseases.As we commemorate the 60th anniversary of EBV's discovery,it is an opportune moment to reflect on the major advancements in our understanding of this complex virus.In this review,we highlight key milestones in EBV research,including its virion structure and life cycle,interactions with the host immune system,association with EBV-associated diseases,and targeted intervention strategies.
