目的:观察玻璃体腔内注射康柏西普治疗不同类型视网膜静脉阻塞(RVO)伴黄斑水肿的临床疗效。方法:回顾性研究。纳入79例79眼不同类型视网膜静脉阻塞伴黄斑水肿患者[视网膜分支静脉阻塞(BRVO)54眼,非缺血型视网膜中央静脉阻塞(non-iCRVO)1...目的:观察玻璃体腔内注射康柏西普治疗不同类型视网膜静脉阻塞(RVO)伴黄斑水肿的临床疗效。方法:回顾性研究。纳入79例79眼不同类型视网膜静脉阻塞伴黄斑水肿患者[视网膜分支静脉阻塞(BRVO)54眼,非缺血型视网膜中央静脉阻塞(non-iCRVO)16眼,缺血型视网膜中央静脉阻塞(iCRVO)9眼],采用3+PRN方案治疗,随访6mo,记录基线、治疗后1d,1、2、3、4、5、6mo的最佳矫正视力(BCVA,LogMAR)、黄斑中心凹视网膜厚度(CMT)等变化。结果:三种不同类型RVO治疗后6mo BCVA均较基线提高(0.22±0.23 vs 0.70±0.32;0.24±0.19 vs 0.73±0.27;1.20±0.37 vs 1.92±0.23;均P<0.05),OCT显示黄斑CMT明显降低(199±27 vs 422±162μm;195±16 vs 550±158μm;231±55 vs 583±152μm;均P<0.05)。三种不同类型RVO在不同就诊时间组内治疗后各时间CMT均较基线下降(P<0.05),不同就诊时间组间CMT均无差异(P>0.05)。BRVO、non-iCRVO患者在不同就诊时间组内治疗后BCVA均较基线改善(P<0.05),iCRVO患者>90d组视力几乎无提升。结论:玻璃体腔内注射康柏西普可以有效治疗RVO引起的黄斑水肿。对于RVO患者,早期及时的进行抗血管内皮生长因子(VEGF)治疗,有助于其远期视力的提高并维持稳定;延迟抗VEGF药物治疗可能会降低其视力提升的空间。展开更多
BACKGROUND With the development of the economy and improvements in living standards,the incidences of diabetes mellitus(DM)and diabetic retinopathy(DR),which is a complication of DM,are on the rise.AIM To analyze earl...BACKGROUND With the development of the economy and improvements in living standards,the incidences of diabetes mellitus(DM)and diabetic retinopathy(DR),which is a complication of DM,are on the rise.AIM To analyze early DR in patients with macular zone changes in biological images using optical coherence tomography angiography METHODS A prospective case study was performed on 59 participants:35 healthy eyes(control group),35 eyes with diabetes but no DR group(no DR group),and 35 eyes with mild DR(NPDR group).All quantitative comparisons of parameters,including the fovea vascularity area,circularity index,and vascular complexity parameters,were performed using a biological image analysis software.RESULTS The foveal avascular zone(FAZ)area,FAZ circularity index,number of branches in the area,and the total of the single branches’length in the area was 0.366±0.031,0.834±0.037,3241.8±268.3,and 3.860×107±0.194×107,and 0.421±0.030,0.739±0.023,2956.6±476.4,and 3.177×107±0.161×107 in the no DR group and the NPDR group,respectively,which were significantly different from the corresponding parameters of the control group(P<0.05).Moreover,there were significant differences between these two groups(P<0.05).CONCLUSION This study shows that early microcirculation changes in the macular area of the retina is associated with disease progression.Early changes in DR can be analyzed using optical coherence tomography angiography.展开更多
文摘目的:观察玻璃体腔内注射康柏西普治疗不同类型视网膜静脉阻塞(RVO)伴黄斑水肿的临床疗效。方法:回顾性研究。纳入79例79眼不同类型视网膜静脉阻塞伴黄斑水肿患者[视网膜分支静脉阻塞(BRVO)54眼,非缺血型视网膜中央静脉阻塞(non-iCRVO)16眼,缺血型视网膜中央静脉阻塞(iCRVO)9眼],采用3+PRN方案治疗,随访6mo,记录基线、治疗后1d,1、2、3、4、5、6mo的最佳矫正视力(BCVA,LogMAR)、黄斑中心凹视网膜厚度(CMT)等变化。结果:三种不同类型RVO治疗后6mo BCVA均较基线提高(0.22±0.23 vs 0.70±0.32;0.24±0.19 vs 0.73±0.27;1.20±0.37 vs 1.92±0.23;均P<0.05),OCT显示黄斑CMT明显降低(199±27 vs 422±162μm;195±16 vs 550±158μm;231±55 vs 583±152μm;均P<0.05)。三种不同类型RVO在不同就诊时间组内治疗后各时间CMT均较基线下降(P<0.05),不同就诊时间组间CMT均无差异(P>0.05)。BRVO、non-iCRVO患者在不同就诊时间组内治疗后BCVA均较基线改善(P<0.05),iCRVO患者>90d组视力几乎无提升。结论:玻璃体腔内注射康柏西普可以有效治疗RVO引起的黄斑水肿。对于RVO患者,早期及时的进行抗血管内皮生长因子(VEGF)治疗,有助于其远期视力的提高并维持稳定;延迟抗VEGF药物治疗可能会降低其视力提升的空间。
基金Ningbo Natural Science Foundation of China,No.2018A610362.
文摘BACKGROUND With the development of the economy and improvements in living standards,the incidences of diabetes mellitus(DM)and diabetic retinopathy(DR),which is a complication of DM,are on the rise.AIM To analyze early DR in patients with macular zone changes in biological images using optical coherence tomography angiography METHODS A prospective case study was performed on 59 participants:35 healthy eyes(control group),35 eyes with diabetes but no DR group(no DR group),and 35 eyes with mild DR(NPDR group).All quantitative comparisons of parameters,including the fovea vascularity area,circularity index,and vascular complexity parameters,were performed using a biological image analysis software.RESULTS The foveal avascular zone(FAZ)area,FAZ circularity index,number of branches in the area,and the total of the single branches’length in the area was 0.366±0.031,0.834±0.037,3241.8±268.3,and 3.860×107±0.194×107,and 0.421±0.030,0.739±0.023,2956.6±476.4,and 3.177×107±0.161×107 in the no DR group and the NPDR group,respectively,which were significantly different from the corresponding parameters of the control group(P<0.05).Moreover,there were significant differences between these two groups(P<0.05).CONCLUSION This study shows that early microcirculation changes in the macular area of the retina is associated with disease progression.Early changes in DR can be analyzed using optical coherence tomography angiography.
