Association of baseline hemoglobin A1c levels with bleeding in patients with non-ST-segment elevation acute coronary syndrome underwent percutaneous coronary intervention:insights of a multicenter cohort study from China

OBJECTIVE To investigate the association between baseline hemoglobin A1c(HbA1c)levels and bleeding in patients with non-ST-segment elevation acute coronary syndrome(NSTE-ACS)who underwent percutaneous coronary intervention(PCI).METHODS This observational cohort study enrolled 6283 consecutive NSTE-ACS patients undergoing PCI from January 1,2010 to December 31,2014.Based on baseline HbA1c levels,the patients were divided into the group with HbA1c<7%(n=4740)and the group with HbA1c≥7%(n=1543).The primary outcomes are major bleeding(BARC grades 3-5)and all-cause death during follow-up.RESULTS Of patients enrolled,4705(74.9%)were male,and 2143(34.1%)had a history of diabetes mellitus,with a mean(SD)age of 64.13(10.32)years.The median follow-up duration was 3.21 years.Compared with the patients with HbA1c<7%,the risk of major bleeding events during follow-up was higher in patients with HbA1c≥7%(adjusted hazard ratio[HR]=1.57;95%con-fidence interval[CI]:1.01-2.44;P=0.044),while the risk of all-cause death during follow-up was not associated with the higher HbA1c levels(adjusted HR=0.88;95%CI:0.66-1.18;P=0.398).CONCLUSIONS Compared with the lower baseline HbA1c levels,the higher baseline HbA1c levels were associated with an increase in long-term bleeding risk in NSTE-ACS patients undergoing PCI,though higher baseline HbA1c levels were not associ-ated with the higher risk in all-cause death.

Theoretical study of BTF/TNA cocrystal: Effects of hydrostatic pressure and temperature

Cocrystallization is a promising technique for the design and preparation of new explosives,and the stability of cocrystal is highly concerned by the researchers.In order to make a better understanding of the behavior of cocrystal under the extreme conditions,DFT(density functional theory) calculation is performed to investigate the effect of hydrostatic pressure on geometrical and electronic structures of the cocrystal BTF(benzotrifuroxan)/TNA(2,4,6-trinitroaniline).When the hydrostatic pressure is applied,the lattice constants,volume,density and total energy change gradually except at the pressures of 40 GPa and 79e83 GPa.It is noteworthy that new chemical bonds form when the pressure is up to83 GPa.The band gap of the cocrystal becomes smaller when the pressure is applied,and finally the cocrystal shows a characteristic of metal.The mechanical property of cocrystal is calculated by MD(molecular dynamics) simulation.The results show that the cocrystal has a better ductibility at low temperature,and has the best tenacity at 295 K.

Reverse Roll Coating Flow with Non-Newtonian Fluids

In this study an incompressible flow with non-Newtonian fluids in the reverse roll coating process was investigated.Non-Newtonian behavior of the coating fluid was accounted by using power law model with power index,n,ranging from 0.8 to 1.2.Effect of roll speed ratio(V2/V1)of the panel roll to the applicator roll and gap distance on the coating film thickness were also investigated.Numerical results were in good agreement with those of experimental data within 15%-20%.Results indicated that the film thickness ratios are function of power-law index,roll speed ration and ratio of roll radius to gap distance.The equations for film thickness ratio were obtained from numerical results as shown below:■,where t1,t2 and t3 are inlet film,transferred film and leakage film thickness,respectively,n is power-law index,V1 and V2 are roll speed of applicator roll and panel roll,Rm is average radius of two rolls and H0 is gap distance.The correlations are accurate within 10%for 0.8≤n≤1.2,0.5≤V_(2)/V_(1)≤2,and 7.7×10^(−5)≤H_(0)/R_(m)≤1.54×10^(−4).