A nickel(Ⅱ)-catalyzed asymmetric alkylation of acyclic oxocarbenium ions generated in situ from corresponding acetals with carboxylic acid derivatives to prepareβ-alkoxyl carbonyl moieties with diverseα-substituent...A nickel(Ⅱ)-catalyzed asymmetric alkylation of acyclic oxocarbenium ions generated in situ from corresponding acetals with carboxylic acid derivatives to prepareβ-alkoxyl carbonyl moieties with diverseα-substituents has been disclosed.The method exhibited broad scope of acetals and carboxylic acid derivatives with excellent enantioselectivity and good functional group compatibility,and can be conducted in a gram-scale without obvious loss of efficiency.展开更多
基金financial supported by the Natural Science Foundation of China(Nos.21722204,21971148)Fok Ying Tung Education Foundation(No.151035)。
文摘A nickel(Ⅱ)-catalyzed asymmetric alkylation of acyclic oxocarbenium ions generated in situ from corresponding acetals with carboxylic acid derivatives to prepareβ-alkoxyl carbonyl moieties with diverseα-substituents has been disclosed.The method exhibited broad scope of acetals and carboxylic acid derivatives with excellent enantioselectivity and good functional group compatibility,and can be conducted in a gram-scale without obvious loss of efficiency.
