Phishing Detection with Image Retrieval Based on Improved Texton Correlation Descriptor

Anti-detection is becoming as an emerging challenge for anti-phishing.This paper solves the threats of anti-detection from the threshold setting condition.Enough webpages are considered to complicate threshold setting condition when the threshold is settled.According to the common visual behavior which is easily attracted by the salient region of webpages,image retrieval methods based on texton correlation descriptor(TCD)are improved to obtain enough webpages which have similarity in the salient region for the images of webpages.There are two steps for improving TCD which has advantage of recognizing the salient region of images:(1)This paper proposed Weighted Euclidean Distance based on neighborhood location(NLW-Euclidean distance)and double cross windows,and combine them to solve the problems in TCD;(2)Space structure is introduced to map the image set to Euclid space so that similarity relation among images can be used to complicate threshold setting conditions.Experimental results show that the proposed method can improve the effectiveness of anti-phishing and make the system more stable,and significantly reduce the possibilities of being hacked to be used as mining systems for blockchain.

Revisit Language Modeling Competition and Extinction: A Data-Driven Validation

Understanding language competition and extinction is an interdisciplinary challenge, and math models provide a tool for interpreting linguistic census data and possibly predict the language shift trend at the population scale. In this study, new data from previously examined areas were modeled, specifically Catalan and Spanish in Catalonia, Spanish and English in Houston, Texas, Dutch and French in Brussels, Euskera and Spanish in Spain and French and English in Canada. Three mathematical models of the language competition have been validated. The first is the Abrams-Strogatz model, which treats populations as having two monolingual groups. The second is the Castelló model, which considers bilingual speakers. The third is the Mira model, which considers language competition when the two languages have high similarities. It was found that the some of the data matched Abrams-Strogatz original model, but some divergences could still be addressed. It was also found that the Mira model needs some improvement in how it treats the differences between languages.

Reprogramming macrophages via immune cell mobilized hydrogel microspheres for osteoarthritis treatments

Regulating macrophage activation precisely is crucial in treating chronic inflammation in osteoarthritis(OA).However,the stable pro-inflammatory state and deep distribution of macrophages in vivo pose a great challenge to treatment.In this study,inspired by the innate immune,immune cell mobilized hydrogel microspheres were constructed by microfluidic methods and load chemokines,macrophage antibodies and engineered cell membrane vesicles(sEVs)via covalent and non-covalent junctions.The immune cell mobilized hydrogel microspheres,based on a mixture of streptavidin grafted hyaluronic acid methacrylate(HAMA-SA)and Chondroitin sulfate methacrylate(ChSMA)microspheres(HCM),can recruit,capture and reprogram proinflammatory macrophages in the joint cavity to improve the joint inflammatory microenvironment.In vitro experiments demonstrated that immune cell mobilized hydrogel microspheres had excellent macrophage recruitment,capture,and reprogramming abilities.Pro-inflammatory macrophages can be transformed into anti-inflammatory macrophages with an efficiency of 88.5%.Animal experiments also revealed significant reduction in synovial inflammation and cartilage matrix degradation of OA.Therefore,the immune cell mobilized hydrogel microspheres may be an effective treatment of OA inflammation for the future.

金属有机框架材料电池隔膜的最新应用

随着新能源行业的快速发展,对于各种不同高性能电池的研究已成为当前的热点。隔膜作为电池的重要组成部分之一,能有效防止电池正负极直接接触并为离子传输提供有利通道。然而,传统聚合物电池隔膜通常存在热稳定性不足、离子输运能力差、电解液浸润性差等问题。金属-有机框架材料(MOFs)作为一种新型的多孔晶体材料,由于其高孔隙率、高比表面积和出色的热稳定性,已成为当前高性能电池隔膜的研究热点。本文综述了各类MOFs/MOFs基材料在电池隔膜中的应用,并全面讨论了MOFs基电池隔膜的优缺点。最后,介绍了MOFs基电池隔膜领域亟待解决的问题以及MOFs在电池隔膜上的发展前景。

Mitochondrial-Oriented Injectable Hydrogel Microspheres Maintain Homeostasis of Chondrocyte Metabolism to Promote Subcellular Therapy in Osteoarthritis

Subcellular mitochondria serve as sensors for energy metabolism and redox balance, and the dynamic regulation of functional and dysfunctional mitochondria plays a crucial role in determining cells' fate. Selective removal of dysfunctional mitochondria at the subcellular level can provide chondrocytes with energy to prevent degeneration, thereby treating osteoarthritis. Herein, to achieve an ideal subcellular therapy, cartilage affinity peptide (WYRGRL)-decorated liposomes loaded with mitophagy activator (urolithin A) were integrated into hyaluronic acid methacrylate hydrogel microspheres through microfluidic technology, named HM@WY-Lip/UA, that could efficiently target chondrocytes and selectively remove subcellular dysfunctional mitochondria. As a result, this system demonstrated an advantage in mitochondria function restoration, reactive oxygen species scavenging, cell survival rescue, and chondrocyte homeostasis maintenance through increasing mitophagy. In a rat post-traumatic osteoarthritis model, the intra-articular injection of HM@WY-Lip/UA ameliorated cartilage matrix degradation, osteophyte formation, and subchondral bone sclerosis at 8 weeks. Overall, this study indicated that HM@WY-Lip/UA provided a protective effect on cartilage degeneration in an efficacious and clinically relevant manner, and a mitochondrial-oriented strategy has great potential in the subcellular therapy of osteoarthritis.

蜂窝状空气滤清器的流场分析及结构优化

基于多孔介质理论,采用标准k-?湍流模型对不同结构的宏观蜂窝状空气滤清器的内部流场和阻力特性进行数值模拟,从而进行结构优化,提高其性能。采用的模型为相同滤芯(褶高h=5mm),壳体进出口形状分别为圆形与圆形(方案1)、圆形与椭圆形(方案2)、椭圆形与圆形(方案3)和椭圆形与椭圆形(方案4)的组合;优化得到的壳体结构与褶高分别为5, 10, 15 mm的蜂窝状滤芯组合,研究其过滤性能。结果表明,方案2的流场分布更均匀;压降随流量变大近似呈线性增长,当流量小于额定流量的60%时,4种方案的压降大致相等,大于额定流量的60%时,方案2的压降比方案1, 3和4小,方案2的壳体结构较合理。方案2滤芯褶高对空气滤清器流场分布有一定影响,且在研究的褶高范围内压降先降低后增加,存在最佳褶高使空气滤清器的压降最小。