LncRNA IDH1-AS1 sponges miR-518c-5p to suppress proliferation of epithelial ovarian cancer cell by targeting RMB47

Long noncoding RNA(lncRNA)IDH1 antisense RNA 1(IDH1-AS1)is involved in the progression of multiple cancers,but its role in epithelial ovarian cancer(EOC)is unknown.Therefore,we investigated the expression levels of IDH1-AS1 in EOC cells and normal ovarian epithelial cells by quantitative real-time PCR(qPCR).We first evaluated the effects of IDH1-AS1 on the proliferation,migration,and invasion of EOC cells through cell counting kit-8,colony formation,EdU,transwell,wound-healing,and xenograft assays.We then explored the downstream targets of IDH1-AS1 and verified the results by a dual-luciferase reporter,qPCR,rescue experiments,and Western blotting.We found that the expression levels of IDH1-AS1 were lower in EOC cells than in normal ovarian epithelial cells.High IDH1-AS1 expression of EOC patients from the Gene Expression Profiling Interactive Analysis database indicated a favorable prognosis,because IDH1-AS1 inhibited cell proliferation and xenograft tumor growth of EOC.IDH1-AS1 sponged miR-518c-5p whose overexpression promoted EOC cell proliferation.The miR-518c-5p mimic also reversed the proliferation-inhibiting effect induced by IDH1-AS1 overexpression.Furthermore,we found that RNA binding motif protein 47(RBM47)was the downstream target of miR-518c-5p,that upregulation of RBM47 inhibited EOC cell proliferation,and that RBM47 overexpressing plasmid counteracted the proliferation-promoting effect caused by the IDH1-AS1 knockdown.Taken together,IDH1-AS1 may suppress EOC cell proliferation and tumor growth via the miR-518c-5p/RBM47 axis.

Improved HardNet and Stricter Outlier Filtering to Guide Reliable Matching

As the fundamental problem in the computer vision area,image matching has wide applications in pose estimation,3D reconstruction,image retrieval,etc.Suffering from the influence of external factors,the process of image matching using classical local detectors,e.g.,scale-invariant feature transform(SIFT),and the outlier filtering approaches,e.g.,Random sample consensus(RANSAC),show high computation speed and pool robustness under changing illumination and viewpoints conditions,while image matching approaches with deep learning strategy(such as HardNet,OANet)display reliable achievements in large-scale datasets with challenging scenes.However,the past learning-based approaches are limited to the distinction and quality of the dataset and the training strategy in the image-matching approaches.As an extension of the previous conference paper,this paper proposes an accurate and robust image matching approach using fewer training data in an end-to-end manner,which could be used to estimate the pose error This research first proposes a novel dataset cleaning and construction strategy to eliminate the noise and improve the training efficiency;Secondly,a novel loss named quadratic hinge triplet loss(QHT)is proposed to gather more effective and stable feature matching;Thirdly,in the outlier filtering process,the stricter OANet and bundle adjustment are applied for judging samples by adding the epipolar distance constraint and triangulation constraint to generate more outstanding matches;Finally,to recall the matching pairs,dynamic guided matching is used and then submit the inliers after the PyRANSAC process.Multiple evaluation metrics are used and reported in the 1st place in the Track1 of CVPR Image-Matching Challenge Workshop.The results show that the proposed method has advanced performance in large-scale and challenging Phototourism benchmark.

Low-Temperature Growing Anatase TiO2/SnO2 Multi-dimensional Heterojunctions at MXene Conductive Network for High-Efficient Perovskite Solar Cells

A multi-dimensional conductive heterojunction structure,composited by TiO2,SnO2,and Ti3C2TX MXene,is facilely designed and applied as electron transport layer in efficient and stable planar perovskite solar cells.Based on an oxygen vacancy scramble effect,the zero-dimensional anatase TiO2 quantum dots,surrounding on two-dimensional conductive Ti3C2TX sheets,are in situ rooted on three-dimensional SnO2 nanoparticles,constructing nanoscale TiO2/SnO2 heterojunctions.The fabrication is implemented in a controlled lowtemperature anneal method in air and then in N2 atmospheres.With the optimal MXene content,the optical property,the crystallinity of perovskite layer,and internal interfaces are all facilitated,contributing more amount of carrier with effective and rapid transferring in device.The champion power conversion efficiency of resultant perovskite solar cells achieves 19.14%,yet that of counterpart is just 16.83%.In addition,it can also maintain almost 85%of its initial performance for more than 45 days in 30–40%humidity air;comparatively,the counterpart declines to just below 75%of its initial performance.

Parameters Sensitivity Analysis and Correction for Concrete Damage Plastic Model

In order to understand the effect of hardening ductility parameters and softening ductility parameters of the concrete damage plastic model in LS-DYNA,a sensitivity and reliability analysis of these parameters through a convenient cube unit test was conducted. The results showed that the peak strength strain was independent of the hardening ductility parameter DH,but affected by AH,BH,and CH. The softening ductility was mainly related to the softening ductility parameter AS,but not affected by the damage ductility exponent BS. In case that the model with default parameters failed to match the AS-controlled damage softening phase,an optimized model with an AS correction was developed. The corrected model with the AS value of 2 matched well with the code model,and exhibited good feasibility in predicting the stress-strain curve of different grades of concrete. Moreover,the practicability of the corrected model was further validated by the conventional triaxial test. The simulated curve exhibited favorable consistence with the trial curve. Therefore,the model with parameter correction could provide a prospective reference for predicting the mechanical properties of concrete.

Study of future power interconnection scheme in ASEAN

The current energy supply trajectory in the Association of Southeast Asian Nations(ASEAN)region is not sustainable.Factors such as rising standards of living and demographic patterns,including population growth,lead to continuous increase in power demand,which is difficult to meet using limited fossil fuel resources.Thus,a transition toward clean energy sources is needed in the region.While ASEAN member countries are rich in clean energy resources,such resources are located far from demand centers;thus,allocation of clean energy is necessary to increase its utilization.In this study,power demand is forecasted using a combination of prediction methods.A model to evaluate the installed capacity and power exchange potential is proposed to deal with mismatch between the location of the clean energy base and the load center.Furthermore,the concept of cross-regional allocation of clean energy between the ASEAN region,China,and South Asia is presented.A power interconnection scheme among the ASEAN member countries as well as neighboring countries is proposed based on the power exchange potential.The proposed grid interconnection scheme contributes to the utilization of clean energy in the ASEAN region,increasing the proportion of clean energy in the generation mix,which ensures that the region becomes a sustainable and resilient society with a clean and low carbon development route.Furthermore,the proposed power interconnection scheme will generate valuable economic,social,environmental,and resource allocation benefits.

Research on Satisfaction of ex situ Relocated Households

Based on the survey data of ex situ relocated households in Hubei and Hunan provinces in 2017,the specific satisfaction levels of the relocated farmers in the two provinces and the influencing factors were analyzed in this paper. It is found that the ex situ relocated farmers in Hubei and Hunan provinces have higher levels of satisfaction. The satisfaction of farmers who have been relocated to poverty alleviation is obviously affected by the characteristics of relocation and support policies. Even after controlling the farmer individual characteristic variables and family characteristic variables,the relocation characteristics and support policies still have a significant impact on the satisfaction of the farmers in the anti-poverty relocation,indicating that the relocated farmers with different backgrounds have a similar understanding of the satisfaction of the ex situ anti-poverty relocation.

Diffusion induced by bounded noise in a two-dimensional coupled memory system

The diffusion behavior driven by bounded noise under the influence of a coupled harmonic potential is investigated in a two-dimensional coupled-damped model. With the help of the Laplace analysis we obtain exact descriptions for a particle’s two-time dynamics which is subjected to a coupled harmonic potential and a coupled damping. The time lag is used to describe the velocity autocorrelation function and mean square displacement of the diffusing particle. The diffusion behavior for the time lag is also discussed with respect to the coupled items and the amplitude of bounded noise.

Study on Pinus elliottii Plantations in Pengchang Forest Farm of Jingmen City

[Objectives]This study was conducted to improve the ecological and economic benefits of Pinus elliottii plantations in Pengchang Forest Farm, Jingmen City. [Methods] P. elliottii plantations in Pengchang Forest Farm in Jingmen City were selected as the research object, and the appearance and quantitative characteristics of P. elliottii community were studied and analyzed by a sampling method. [Results] Phanerophytes were the most in the P. elliottii community, accounting for 50%. In the community, except P. elliottii, the importance values of native plants were higher. The order of species diversity of P. elliottii community in Pengchang Forest Farm was herb layer, tree layer and shrub layer. The stress resistance of the community was weak, and strong intraspecific competition existed in P. elliottii. It is recommended to thin P. elliottii trees with insufficient lighting, poor growth potential and severely damaged tree body, and interplant Phoebe zhennan after thinning the P. elliottii plantations, so as to create a coniferous and broad-leaved evergreen mixed forest. [Conclusions] This study provides scientific support for thinning, tending, and forest management of P. elliottii plantations.

The High Surface Ratio Micro-MoS₂Grain Composed of MoS₂Nanosheet Prepared with One-Step Hydrothermal Synthesis

Micro molybdenum disulfide was prepared with one-step hydrothermal method;the influence of reactant concentration and temperature on the surface ratio of micro-MoS2 grain was investigated. Raman spectroscopy (Raman), X-ray diffraction (XRD), and Scanning electron microscopy (SEM) were used to characterize the structure, composition and morphology of MoS2. The results show that micro-MoS2 grains were synthesized with one-step hydrothermal synthesis, and the morphology of micro-MoS2 grains is like flower and sphere. The SEM figures indicate that the surface ratio of micro-MoS2 grains is different and also show that the surface ratio of micro-MoS2 grains can be improved by regulating reactant concentration and temperature. This research showed a method to improve the surface ratio of micro-MoS2 grains.

气候作用对沥青混合料性能的影响

气候作用(如雨、日、冰)是沥青路面老化的主要原因之一,这些气候因子对沥青混合料影响可能是长期雨天或晴天的老化过程,也可能是由于温度变化范围大而引起的一系列冻融循环,然而,室内研究主要集中在气候作用的短期效应上。因此,本文针对两种不同的沥青混合料(密级配和开级配),分析长期受潮、多次冻融循环和不同热老化时间下其强度和刚度的变化规律。研究发现:在水分作用下空隙率对沥青混合料的长期性能演变有显著影响,这是一个不同于其他两种气候因子的可逆过程。另一方面,冻融循环对密级配沥青混合料的影响更大,无论空隙率如何,冻融循环都是一个短期过程,而热老化对两种沥青混合料的性能变化最小。

Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis

Sulfation is a crucial and prevalent conjugation reaction involved in cellular processes and mammalian physiology.3’-Phosphoadenosine 5’-phosphosulfate(PAPS)synthase 2(PAPSS2)is the primary enzyme to generate the universal sulfonate donor PAPS.The involvement of PAPSS2-mediated sulfation in adenomatous polyposis coli(APC)mutation-promoted colonic carcinogenesis has not been reported.Here,we showed that the expression of PAPSS2 was decreased in human colon tumors along with cancer stages,and the lower expression of PAPSS2 was correlated with poor prognosis in advanced colon cancer.Gut epithelial-specific heterozygous Apc deficient and Papss2-knockout(Apc^(Δgut-Het)Papss2^(Δgut))mice were created,and the phenotypes were compared to the spontaneous intestinal tumorigenesis of Apc^(Δgut-Het)mice.Apc^(Δgut-Het)Papss2^(Δgutmice) were more sensitive to gut tumorigenesis,which was mechanistically accounted for by the activation of Wnt/β-catenin signaling pathway due to the suppression of chondroitin sulfation and inhibition of the farnesoid X receptor(FXR)-transducin-like enhancer of split 3(TLE3)gene regulatory axis.Chondroitin sulfate supplementation in Apc^(Δgut-Het)Papss2^(Δgutmice) alleviated intestinal tumorigenesis.In summary,we have uncovered the protective role of PAPSS2-mediated chondroitin sulfation and bile acids-FXR-TLE3 activation in the prevention of gut carcinogenesis via the antagonization of Wnt/β-catenin signaling.Chondroitin sulfate may be explored as a therapeutic agent for Papss2 deficiency-associated colonic carcinogenesis.

Structure and mechanical properties of windmill palm fiber with different delignification treatments

The removal of lignin from natural cellulose fibers is a crucial step in preparing high-performance materials,such as compressed high-toughness composites.This process can eliminate non-cellulosic impurities,create abundant compressible pores,and expose a greater number of active functional groups.In this study,biomass waste windmill palm fiber was used as the raw mate-rial to prepare holocellulose fibers through various chemical treatments.The structure,chemical composition,Fourier transform infrared spectroscopy analysis,X-ray diffraction analysis,ther-mal properties,and mechanical properties,particularly fatigue performance,were studied.The sodium chlorite treated fiber had the highest crystallinity index(61.3%)and the most complete appearance structure.The sodium sulfite treated fiber had the highest tensile strength(227.34±52.27)MPa.Hydroxide peroxide treatment removed most of the lignin and hemicellulose,increas-ing the cellulose content to 68.83%±0.65%.However,all the chemical treatments decreased the thermal property of the fibers.

ASCFL:Accurate and Speedy Semi-Supervised Clustering Federated Learning

The influence of non-Independent Identically Distribution(non-IID)data on Federated Learning(FL)has been a serious concern.Clustered Federated Learning(CFL)is an emerging approach for reducing the impact of non-IID data,which employs the client similarity calculated by relevant metrics for clustering.Unfortunately,the existing CFL methods only pursue a single accuracy improvement,but ignore the convergence rate.Additionlly,the designed client selection strategy will affect the clustering results.Finally,traditional semi-supervised learning changes the distribution of data on clients,resulting in higher local costs and undesirable performance.In this paper,we propose a novel CFL method named ASCFL,which selects clients to participate in training and can dynamically adjust the balance between accuracy and convergence speed with datasets consisting of labeled and unlabeled data.To deal with unlabeled data,the prediction labels strategy predicts labels by encoders.The client selection strategy is to improve accuracy and reduce overhead by selecting clients with higher losses participating in the current round.What is more,the similarity-based clustering strategy uses a new indicator to measure the similarity between clients.Experimental results show that ASCFL has certain advantages in model accuracy and convergence speed over the three state-of-the-art methods with two popular datasets.

Recent advances in cathodes for all-solid-state lithium-sulfur batteries

Lithium-sulfur(Li-S)batteries have been regarded as the candidate for the next-generation energy storage system due to the high theoretical specific capacity(1675 m Ah/g), energy density(2600 Wh/kg)and the abundance of elemental sulfur, but the application of Li-S batteries is impeded by a series of problems. Recently, all-solid-state Li-S batteries(ASSLSBs) have drawn great attention because many drawbacks such as safety issues caused by metallic lithium anodes and organic liquid electrolytes can be overcome through the use of solid-state electrolytes(SEs). However, not only the problems brought by sulfur cathodes still exist, but more trouble arouses from the interfaces between SEs and cathodes, hampering the practical application of ASSLSBs. Therefore, in order to deal with the problems, enormous endeavors have been done on ASSLSB cathodes during the past few decades, including engineering of cathode active materials, cathode host materials, cathode binder materials and cathode structures. In this review, the electrochemical mechanism and existing problems of ASSLSBs are briefly introduced. Subsequently, the strategies for developing cathode materials and designing cathode structures are presented. Then there follows a brief discussion of SE problems and expectations, and finally, the challenges and perspectives of ASSLSBs are summarized.

Harnessing the magic of light:spatial coherence instructed swin transformer for universal holographic imaging

.Holographic imaging poses significant challenges when facing real-time disturbances introduced by dynamic environments.The existing deep-learning methods for holographic imaging often depend solely on the specific condition based on the given data distributions,thus hindering their generalization across multiple scenes.One critical problem is how to guarantee the alignment between any given downstream tasks and pretrained models.We analyze the physical mechanism of image degradation caused by turbulence and innovatively propose a swin transformer-based method,termed train-with-coherence-swin(TWC-Swin)transformer,which uses spatial coherence(SC)as an adaptable physical prior information to precisely align image restoration tasks in the arbitrary turbulent scene.The light-processing system(LPR)we designed enables manipulation of SC and simulation of any turbulence.Qualitative and quantitative evaluations demonstrate that the TWC-Swin method presents superiority over traditional convolution frameworks and realizes image restoration under various turbulences,which suggests its robustness,powerful generalization capabilities,and adaptability to unknown environments.Our research reveals the significance of physical prior information in the optical intersection and provides an effective solution for model-to-tasks alignment schemes,which will help to unlock the full potential of deep learning for all-weather optical imaging across terrestrial,marine,and aerial domains.

Transcription factor ETV4 promotes the development of hepatocellular carcinoma by driving hepatic TNF-αsignaling

Background Hepatic inflammation is the major risk factor of hepatocellular carcinoma(HCC).However,the underlying mechanism by which hepatic inflammation progresses to HCC is poorly understood.This study was designed to investigate the role of ETS translocation variant 4(ETV4)in linking hepatic inflammation to HCC.Methods Quantitative real-time PCR and immunoblotting were used to detect the expression of ETV4 in HCC tissues and cell lines.RNA sequencing and luciferase reporter assays were performed to identify the target genes of ETV4.Hepatocyte-specific ETV4-knockout(ETV4fl/fl,alb-cre)and transgenic(ETV4Hep-TG)mice and diethylnitrosamine-carbon tetrachloride(DEN-CCL4)treatment experiments were applied to investigate the function of ETV4 in vivo.The Cancer Genome Atlas(TCGA)database mining and pathological analysis were carried out to determine the correlation of ETV4 with tumor necrosis factor-alpha(TNF-α)and mitogen-activated protein kinase 11(MAPK11).Results We revealed that ETV4 was highly expressed in HCC.High levels of ETV4 predicted a poor survival rate of HCC patients.Then we identified ETV4 as a transcription activator of TNF-αand MAPK11.ETV4 was positively correlated with TNF-αand MAPK11 in HCC patients.As expected,an increase in hepatic TNF-αsecretion and macrophage accumulation were observed in the livers of ETV4Hep-TG mice.The protein levels of TNF-α,MAPK11,and CD68 were significantly higher in the livers of ETV4Hep-TG mice compared with wild type mice but lower in ETV4fl/fl,alb-cre mice compared with ETV4fl/fl mice as treated with DEN-CCL4,indicating that ETV4 functioned as a driver of TNF-α/MAPK11 expression and macrophage accumulation during hepatic inflammation.Hepatocyte-specific knockout of ETV4 significantly prevented development of DEN-CCL4-induced HCC,while transgenic expression of ETV4 promoted growth of HCC.Conclusions ETV4 promoted hepatic inflammation and HCC by activating transcription of TNF-αand MAPK11.Both the ETV4/TNF-αand ETV4/MAPK11 axes represented two potential therapeutic targets for highly associated hepatic inflammation and HCC.ETV4+TNF-αwere potential prognostic markers for HCC patients.

High-performance flexible organic field effect transistors with print-based nanowires

Polymer nanowire(NW)organic field-effect transistors(OFETs)integrated on highly aligned large-area flexible substrates are candidate structures for the development of high-performance flexible electronics.This work presents a universal technique,coaxial focused electrohydrodynamic jet(CFEJ)printing technology,to fabricate highly aligned 90-nm-diameter polymer arrays.This method allows for the preparation of uniformly shaped and precisely positioned nanowires directly on flexible substrates without transfer,thus ensuring their electrical properties.Using indacenodithiophene-co-benzothiadiazole(IDT-BT)and poly(9,9-dioctylfluorene-co-benzothiadiazole)(F8-BT)as example materials,5 cm^(2) arrays were prepared with only minute size variations,which is extremely difficult to do using previously reported methods.According to 2D-GIXRD analysis,the molecules inside the nanowires mainly adopted face-onπ-stacking crystallite arrangements.This is quite different from the mixed arrangement of thin films.Nanowire-based OFETs exhibited a high average hole mobility of 1.1 cm^(2) V^(−1) s^(−1) and good device uniformity,indicating the applicability of CFEJ printing as a potential batch manufacturing and integration process for high-performance,scalable polymer nanowire-based OFET circuits.This technique can be used to fabricate various polymer arrays,enabling the use of organic polymer semiconductors in large-area,high-performance electronic devices and providing a new path for the fabrication of flexible displays and wearable electronics in the future.

树木风载及其安全性评估研究进展

作为具有生态价值、经济价值和文化价值等多重价值的生物载体,树木是一种重要的自然资源。自然界中树木的生长、生存始终面临着各种威胁和挑战,其中最大、最不可控的危险因素是风。过高的风载荷可能导致树木整体倾斜、树干弯曲、枝叶折断、折干倒伏以及掘根倒伏等形式的破坏,从而带来严重的生态、经济和文化等方面的损失,而且可能危及人们的生命财产安全。为了保护树木、减少损失,文中对树木风载及其安全性评估的研究进展进行综述。介绍独立树木、林缘树木和林内树木的树木风载荷计算方法;阐述树木折干倒伏和掘根倒伏的安全性检测和评估的研究进展,总结现有评价模型的表现和效果,并概述树木动态响应的影响;提出目前研究中存在的问题,并对未来发展进行展望。

Stereoselective Synthesis of （-）-Chloramphenicol, （＋）-Thiamphenicol and （＋）-Sphinganine via Chiral Tricyclic Iminolactone

stereoselective 综合体()-chloramphenicol,(+)-thiamphenicol 和(+)-sphinganine 被描述。在三个目标分子以内的二个连续 chiral 中心通过 chiral tricyclic iminolactone 和醛的丁间醇醛反应被构造。