Trauma and neurosurgery often result in dural defects and are followed by serious complications or even death, finding suitable dural replacement materials to repair the defective dura has important clinical significa...Trauma and neurosurgery often result in dural defects and are followed by serious complications or even death, finding suitable dural replacement materials to repair the defective dura has important clinical significance. Porcine peritoneal acellular matrix(PPAM) is a promising alternative material, but its poor stability makes it difficult to meet the various needs of dural reconstruction. In this work, we developed a novel antibacterial cross-linking agent oxidized quaternized guar gum(OQGG) and used it for the first time to stabilize PPAM to construct a dural mater substitute(OQGG-PPAM). The results showed that 1.5%OQGG-PPAM presented suitable mechanical property as well as good thermal stability and resistance to enzymatic degradation. It also exhibited good antibacterial activity and good anti-leakage ability. Furthermore, 1.5% OQGG-PPAM not only exhibited excellent cell compatibility but also significantly stimulated the secretion of b FGF and VEGF from seeded cells which was convenient for dural remodeling. In vivo experiment, it also exhibited the excellent histocompatibility and good anti-adhesion property. This study showed that OQGG can be used as a novel antibacterial cross-linking reagent for crosslinking natural tissues and 1.5% OQGG-PPAM was a potential candidate material for dura mater substitute.展开更多
Freestanding MXene-based macroforms have gained significant attention as versatile components in electrochemical energy storage applications owing to their interconnected conductive network,strong mechanical strength,...Freestanding MXene-based macroforms have gained significant attention as versatile components in electrochemical energy storage applications owing to their interconnected conductive network,strong mechanical strength,and customizable surface chemistries derived from MXene nanosheets.This comprehensive review article encompasses key aspects related to the synthesis of MXene nanosheets,strategies for structure design and surface medication,surface modification,and the diverse fabrication methods employed to create freestanding MXene-based macroform architectures.The review also delves into the recent advancements in utilizing freestanding MXene macroforms for electrochemical energy storage applications,offering a detailed discussion on the significant progress achieved thus far.Notably,the correlation between the macroform’s structural attributes and its performance characteristics is thoroughly explored,shedding light on the critical factors influencing efficiency and durability.Despite the remarkable development,the review also highlights the existing challenges and presents future perspectives for freestanding MXenebased macroforms in the realms of high-performance energy storage devices.By addressing these challenges and leveraging emerging opportunities,the potential of freestanding MXene-based macroforms can be harnessed to enable groundbreaking advancements in the field of energy storage.展开更多
Multiple strain sensors are required to identify individual forces/stresses on human joints and recognize how they work together in order to determine the motion’s direction and trajectory.However,current sensors can...Multiple strain sensors are required to identify individual forces/stresses on human joints and recognize how they work together in order to determine the motion’s direction and trajectory.However,current sensors cannot detect and differentiate the individual forces/stresses and their contributions to the motion from the sensors’electrical signals.To address this critical issue,we propose a concept of unimodal tension,bend,shear,and twist strain sensors with piezoelectric poly L-lactic acid films.We then construct an integrated unimodal sensor(i-US)using the unimodal sensors and prove that the i-US can detect and differentiate individual strain modes,such as tensioning,bending,shearing,and twisting in complex motion.To demonstrate the potential impact of unimodal sensors,we design a sleeve and a glove with the i-US that can capture wrist motions and finger movements.Therefore,we expect unimodal strain sensors to provide a turning point in developing motion recognition and control systems.展开更多
基金financially supported by the National Natural Science Foundation of China (21808189, 21663027)the Science and Technology Support Project of Gansu Province (1504GKCA027)+2 种基金the Program for Innovative Research Team (NWNULKQN-15-2)the Opening Project of Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control (GKLECPC-12)the Opening Project of Key Laboratory of Green Catalysis of Sichuan Institutes of High Education (LYJ18205)~~
基金financially supported by the National Key Research and Development Program of China(Nos.2016YFC1100900,2016YFC1100901,2016YFC1100903 and 2016YFC1100904)the Key Research and Development Program of Sichuan Province(No.2019YFS0121)。
文摘Trauma and neurosurgery often result in dural defects and are followed by serious complications or even death, finding suitable dural replacement materials to repair the defective dura has important clinical significance. Porcine peritoneal acellular matrix(PPAM) is a promising alternative material, but its poor stability makes it difficult to meet the various needs of dural reconstruction. In this work, we developed a novel antibacterial cross-linking agent oxidized quaternized guar gum(OQGG) and used it for the first time to stabilize PPAM to construct a dural mater substitute(OQGG-PPAM). The results showed that 1.5%OQGG-PPAM presented suitable mechanical property as well as good thermal stability and resistance to enzymatic degradation. It also exhibited good antibacterial activity and good anti-leakage ability. Furthermore, 1.5% OQGG-PPAM not only exhibited excellent cell compatibility but also significantly stimulated the secretion of b FGF and VEGF from seeded cells which was convenient for dural remodeling. In vivo experiment, it also exhibited the excellent histocompatibility and good anti-adhesion property. This study showed that OQGG can be used as a novel antibacterial cross-linking reagent for crosslinking natural tissues and 1.5% OQGG-PPAM was a potential candidate material for dura mater substitute.
基金Startup Research Fund of Henan Academy of Sciences,Grant/Award Number:231817001China Scholarship Council(CSC)+2 种基金German Research Foundation(DFG),Grant/Award Number:448719339Sachsisches Staatsministerium furWissenschaft und Kunst(Sonderzuweisung zur Unterstutzung profilbestimmender Struktureinheiten)Federal Ministry of Education and Research(BMBF),Grant/Award Numbers:03XP0390C,03XP0254D。
文摘Freestanding MXene-based macroforms have gained significant attention as versatile components in electrochemical energy storage applications owing to their interconnected conductive network,strong mechanical strength,and customizable surface chemistries derived from MXene nanosheets.This comprehensive review article encompasses key aspects related to the synthesis of MXene nanosheets,strategies for structure design and surface medication,surface modification,and the diverse fabrication methods employed to create freestanding MXene-based macroform architectures.The review also delves into the recent advancements in utilizing freestanding MXene macroforms for electrochemical energy storage applications,offering a detailed discussion on the significant progress achieved thus far.Notably,the correlation between the macroform’s structural attributes and its performance characteristics is thoroughly explored,shedding light on the critical factors influencing efficiency and durability.Despite the remarkable development,the review also highlights the existing challenges and presents future perspectives for freestanding MXenebased macroforms in the realms of high-performance energy storage devices.By addressing these challenges and leveraging emerging opportunities,the potential of freestanding MXene-based macroforms can be harnessed to enable groundbreaking advancements in the field of energy storage.
基金supported by the EU Horizon 2020 through project ETEXWELD-H2020-MSCA-RISE-2014 (Grant No.644268)the University of Manchester through the UMRI project-Graphene-Smart Textiles E-Healthcare Network (Grant No.AA14512)the Engineering and Physical Sciences Research Council (EPSRC)of UK (Grant EP/V057782/1).
文摘Multiple strain sensors are required to identify individual forces/stresses on human joints and recognize how they work together in order to determine the motion’s direction and trajectory.However,current sensors cannot detect and differentiate the individual forces/stresses and their contributions to the motion from the sensors’electrical signals.To address this critical issue,we propose a concept of unimodal tension,bend,shear,and twist strain sensors with piezoelectric poly L-lactic acid films.We then construct an integrated unimodal sensor(i-US)using the unimodal sensors and prove that the i-US can detect and differentiate individual strain modes,such as tensioning,bending,shearing,and twisting in complex motion.To demonstrate the potential impact of unimodal sensors,we design a sleeve and a glove with the i-US that can capture wrist motions and finger movements.Therefore,we expect unimodal strain sensors to provide a turning point in developing motion recognition and control systems.
