The precise control of turbofan engines thrust is an important guarantee for an aircraft to obtain good flight performance and a challenge due to complex nonlinear dynamics of engines and time-varying parameters. The ...The precise control of turbofan engines thrust is an important guarantee for an aircraft to obtain good flight performance and a challenge due to complex nonlinear dynamics of engines and time-varying parameters. The main difficulties lie in the following two aspects. Firstly, it is hard to obtain an accurate kinetic model for the turbofan engine. Secondly, some model parameters often change in different flight conditions and states and even fluctuate sharply in some cases. These variable parameters bring huge challenge for the turbofan engine control. To solve the turbofan engine control problem, this paper presents a non-affine parameter-dependent Linear Parameter Varying(LPV) model-based adaptive control approach. In this approach, polynomial-based LPV modeling method is firstly employed to obtain the basis matrices, and then the Radial Basis Function Neural Networks(RBFNN) is introduced for the online estimation of the non-affine model parameters to improve the simulation performance. LPV model-based Linear Matrix Inequality(LMI) control method is applied to derive the control law. A robust control term is introduced to fix the estimation error of the nonlinear time-varying model parameters for better control performance. Finally, the Lyapunov stability analysis is performed to ensure the asymptotical convergence of the closed loop system. The simulation results show that the states of the engine can change smoothly and the thrust of the engine can accurately follow the desired trajectory, indicating that the proposed control approach is effective. The contribution of this work lies in the combination of linear system control and nonlinear system control methods to design an effective controller for the turbofan engine and to provide a new way for turbofan engine control research.展开更多
Neomycin belongs to the family of 2-deoxystreptamine-containing aminoglycoside antibiotics.It is widely used for bacterial infections,targeting most gram-negative and some gram-positive bacteria.Neomycin has also been...Neomycin belongs to the family of 2-deoxystreptamine-containing aminoglycoside antibiotics.It is widely used for bacterial infections,targeting most gram-negative and some gram-positive bacteria.Neomycin has also been reported to show antiviral activity.Here,we evaluated the toxicity of neomycin sulfate,and investigated its effect on non-specific immunity and viral infection in crucian carp(Carassius auratus gibelio).The safe concentration of neomycin sulfate for crucian carp was determined to be 102.9 mg/kg in vivo.In oxidative damage assays,neomycin sulfate increased superoxide dismutase and catalase activity and decreased malondialdehyde in the liver of crucian carp.In non-specific blood immune assays,the white blood cell count and complement 3 content significantly increased after neomycin sulfate treatment,while no significant changes were observed in antibacterial or lysozyme activity.In a challenge test,neomycin sulfate protected the crucian carp from cyprinid herpesvirus 2(CyHV-2)infection and inhibited CyHV-2 replication.In cytotoxicity assays,low concentrations of neomycin sulfate had no cytotoxicity on cells from the fins of crucian carp.The results of the present study indicate that oral administration of neomycin sulfate reduced oxidative damage,enhanced immunity and provided protection against CyHV-2 in crucian carp.展开更多
基金supported by the National Natural Science Foundation of China(No.51766011)the Aeronautical Science Foundation of China(No.2014ZB56002)
文摘The precise control of turbofan engines thrust is an important guarantee for an aircraft to obtain good flight performance and a challenge due to complex nonlinear dynamics of engines and time-varying parameters. The main difficulties lie in the following two aspects. Firstly, it is hard to obtain an accurate kinetic model for the turbofan engine. Secondly, some model parameters often change in different flight conditions and states and even fluctuate sharply in some cases. These variable parameters bring huge challenge for the turbofan engine control. To solve the turbofan engine control problem, this paper presents a non-affine parameter-dependent Linear Parameter Varying(LPV) model-based adaptive control approach. In this approach, polynomial-based LPV modeling method is firstly employed to obtain the basis matrices, and then the Radial Basis Function Neural Networks(RBFNN) is introduced for the online estimation of the non-affine model parameters to improve the simulation performance. LPV model-based Linear Matrix Inequality(LMI) control method is applied to derive the control law. A robust control term is introduced to fix the estimation error of the nonlinear time-varying model parameters for better control performance. Finally, the Lyapunov stability analysis is performed to ensure the asymptotical convergence of the closed loop system. The simulation results show that the states of the engine can change smoothly and the thrust of the engine can accurately follow the desired trajectory, indicating that the proposed control approach is effective. The contribution of this work lies in the combination of linear system control and nonlinear system control methods to design an effective controller for the turbofan engine and to provide a new way for turbofan engine control research.
基金This work was supported by the Earmarked Fund for China Agriculture Research System(grant number CARS-45-19).The authors report no conflicts of interest in this paper.
文摘Neomycin belongs to the family of 2-deoxystreptamine-containing aminoglycoside antibiotics.It is widely used for bacterial infections,targeting most gram-negative and some gram-positive bacteria.Neomycin has also been reported to show antiviral activity.Here,we evaluated the toxicity of neomycin sulfate,and investigated its effect on non-specific immunity and viral infection in crucian carp(Carassius auratus gibelio).The safe concentration of neomycin sulfate for crucian carp was determined to be 102.9 mg/kg in vivo.In oxidative damage assays,neomycin sulfate increased superoxide dismutase and catalase activity and decreased malondialdehyde in the liver of crucian carp.In non-specific blood immune assays,the white blood cell count and complement 3 content significantly increased after neomycin sulfate treatment,while no significant changes were observed in antibacterial or lysozyme activity.In a challenge test,neomycin sulfate protected the crucian carp from cyprinid herpesvirus 2(CyHV-2)infection and inhibited CyHV-2 replication.In cytotoxicity assays,low concentrations of neomycin sulfate had no cytotoxicity on cells from the fins of crucian carp.The results of the present study indicate that oral administration of neomycin sulfate reduced oxidative damage,enhanced immunity and provided protection against CyHV-2 in crucian carp.