Heart failure with preserved ejection fraction(HFPEF)is common and represents a major challenge in cardiovascular medicine.Most of the current treatment of HFPEF is based on morbidity benefits and symptom reduction.Va...Heart failure with preserved ejection fraction(HFPEF)is common and represents a major challenge in cardiovascular medicine.Most of the current treatment of HFPEF is based on morbidity benefits and symptom reduction.Various pharmacological interventions available for heart failure with reduced ejection fraction have not been supported by clinical studies for HFPEF.Addressing the specific aetiology and aggressive risk factor modification remain the mainstay in the treatment of HFPEF.We present a brief overview of the currently recommended therapeutic options with available evidence.展开更多
BACKGROUND The left internal mammary artery(LIMA)has demonstrated excellent long-term patency rates when used as a bypass conduit with complications usually occurring in the early postoperative period.The rapid develo...BACKGROUND The left internal mammary artery(LIMA)has demonstrated excellent long-term patency rates when used as a bypass conduit with complications usually occurring in the early postoperative period.The rapid development of de-novo atherosclerosis in a previously non-diseased LIMA,subsequently leading to an acute coronary syndrome(ACS)is rarely encountered.CASE SUMMARY A 67-year-old man with history of triple coronary artery bypass graft(8 years ago)presented to our hospital with an ACS.He had undergone angiography 5 years ago to investigate episodic chest pain and imaging of the LIMA at the time did not demonstrate the atherosclerotic process.Emergent angiography demonstrated a severe diffuse stenosis in the proximal to mid segment of the LIMA,with embolization of a moderate sized thrombus to the distal skip segment.The LIMA stenosis was characterised by overlying haziness,consistent with acute plaque rupture,associated with residual luminal thrombus.The patient was managed with antithrombotic therapy to reduce the thrombus burden until repeat angiography after 72 h.At repeat angiography,the thrombus burden was substantially reduced at the distal skip segment as well as at the proximal to mid LIMA with the demonstration of multiple plaque cavities.This lesion was predilated and a 2.75 mm×33 mm everolimus-eluting stent was implanted to a final diameter of 3.0 mm.The patient made a good clinical recovery and was discharged after 6 d.CONCLUSION This case highlights the rapid and late development of atherosclerosis in a graft 5 years after documented patency and the importance for consideration of expectant thrombus management.展开更多
Cardiac resynchronization therapy (CRT) is an established therapy for selected heart failure (HF) patients to improve symptoms, ventricular function, and survival. Although increasingly used, left ventricular (LV) dys...Cardiac resynchronization therapy (CRT) is an established therapy for selected heart failure (HF) patients to improve symptoms, ventricular function, and survival. Although increasingly used, left ventricular (LV) dyssynchrony assessment by echocardiography has failed to show enough predictive value to assess patient response to CRT and the current guidelines do not recommend its routine use. Furthermore, a variety of echocardiographic techniques used for the purpose, including tissue Doppler imaging (TDI), real time three-dimensional echocardiography, M-mode, and various Doppler parameters, showed limited value and poor agreement between the studies and methods, greatly influenced by interobserver variability. Speckle tracking echocardiography (STE) is a more recent approach that uses strain imaging to assess LV dyssynchrony. This article discusses the speckle tracking for LV dyssynchrony and its current clinical applications.展开更多
文摘Heart failure with preserved ejection fraction(HFPEF)is common and represents a major challenge in cardiovascular medicine.Most of the current treatment of HFPEF is based on morbidity benefits and symptom reduction.Various pharmacological interventions available for heart failure with reduced ejection fraction have not been supported by clinical studies for HFPEF.Addressing the specific aetiology and aggressive risk factor modification remain the mainstay in the treatment of HFPEF.We present a brief overview of the currently recommended therapeutic options with available evidence.
文摘BACKGROUND The left internal mammary artery(LIMA)has demonstrated excellent long-term patency rates when used as a bypass conduit with complications usually occurring in the early postoperative period.The rapid development of de-novo atherosclerosis in a previously non-diseased LIMA,subsequently leading to an acute coronary syndrome(ACS)is rarely encountered.CASE SUMMARY A 67-year-old man with history of triple coronary artery bypass graft(8 years ago)presented to our hospital with an ACS.He had undergone angiography 5 years ago to investigate episodic chest pain and imaging of the LIMA at the time did not demonstrate the atherosclerotic process.Emergent angiography demonstrated a severe diffuse stenosis in the proximal to mid segment of the LIMA,with embolization of a moderate sized thrombus to the distal skip segment.The LIMA stenosis was characterised by overlying haziness,consistent with acute plaque rupture,associated with residual luminal thrombus.The patient was managed with antithrombotic therapy to reduce the thrombus burden until repeat angiography after 72 h.At repeat angiography,the thrombus burden was substantially reduced at the distal skip segment as well as at the proximal to mid LIMA with the demonstration of multiple plaque cavities.This lesion was predilated and a 2.75 mm×33 mm everolimus-eluting stent was implanted to a final diameter of 3.0 mm.The patient made a good clinical recovery and was discharged after 6 d.CONCLUSION This case highlights the rapid and late development of atherosclerosis in a graft 5 years after documented patency and the importance for consideration of expectant thrombus management.
文摘Cardiac resynchronization therapy (CRT) is an established therapy for selected heart failure (HF) patients to improve symptoms, ventricular function, and survival. Although increasingly used, left ventricular (LV) dyssynchrony assessment by echocardiography has failed to show enough predictive value to assess patient response to CRT and the current guidelines do not recommend its routine use. Furthermore, a variety of echocardiographic techniques used for the purpose, including tissue Doppler imaging (TDI), real time three-dimensional echocardiography, M-mode, and various Doppler parameters, showed limited value and poor agreement between the studies and methods, greatly influenced by interobserver variability. Speckle tracking echocardiography (STE) is a more recent approach that uses strain imaging to assess LV dyssynchrony. This article discusses the speckle tracking for LV dyssynchrony and its current clinical applications.
