The formability of aluminum alloy AA7075 at elevated temperature was investigated through experiment. Stress-strain relationship at different temperatures and forming speeds were investigated through tensile testing. ...The formability of aluminum alloy AA7075 at elevated temperature was investigated through experiment. Stress-strain relationship at different temperatures and forming speeds were investigated through tensile testing. Deep drawing and stretch formability were also tested through limiting drawing ratio （LDR） and limiting dome height （LDH） tests. Finally, post forming mechanical property testing was conducted to investigate the effects of exposure to warm forming temperatures on the mechanical properties. Results show that deep drawing and stretch formability of AA7075 can be significantly improved when the blank is heated to 140-220 °C. At temperature over 260 °C, formability and post forming mechanical properties begin to decrease due to the effect of the heating and forming processes on the material＇s temper.展开更多
The degree to, and the mechanisms through, which stem cells are able to build, maintain, and heal the body have only recently begun to be understood. Much of the stem cell's power resides in the release of a multi...The degree to, and the mechanisms through, which stem cells are able to build, maintain, and heal the body have only recently begun to be understood. Much of the stem cell's power resides in the release of a multitude of molecules, called stem cell released molecules(SRM). A fundamentally new type of therapeutic, namely "systems therapeutic", can be realized by reverse engineering the mechanisms of the SRM processes. Recent data demonstrates that the composition of the SRM is different for each type of stem cell, as well as for different states of each cell type. Although systemsbiology has been successfully used to analyze multiple pathways, the approach is often used to develop a small molecule interacting at only one pathway in the system. A new model is emerging in biology where systems biology is used to develop a new technology acting at multiple pathways called "systems therapeutics". A natural set of healing pathways in the human that uses SRM is instructive and of practical use in developing systems therapeutics. Endogenous SRM processes in the human body use a combination of SRM from two or more stem cell types, designated as S2 RM, doing so under various state dependent conditions for each cell type. Here we describe our approach in using statedependent SRM from two or more stem cell types, S2 RM technology, to develop a new class of therapeutics called "systems therapeutics." Given the ubiquitous and powerful nature of innate S2RM-based healing in the human body, this "systems therapeutic" approach using S2 RM technology will be important for the development of anti-cancer therapeutics, antimicrobials, wound care products and procedures, and a number of other therapeutics for many indications.展开更多
文摘The formability of aluminum alloy AA7075 at elevated temperature was investigated through experiment. Stress-strain relationship at different temperatures and forming speeds were investigated through tensile testing. Deep drawing and stretch formability were also tested through limiting drawing ratio （LDR） and limiting dome height （LDH） tests. Finally, post forming mechanical property testing was conducted to investigate the effects of exposure to warm forming temperatures on the mechanical properties. Results show that deep drawing and stretch formability of AA7075 can be significantly improved when the blank is heated to 140-220 °C. At temperature over 260 °C, formability and post forming mechanical properties begin to decrease due to the effect of the heating and forming processes on the material＇s temper.
文摘The degree to, and the mechanisms through, which stem cells are able to build, maintain, and heal the body have only recently begun to be understood. Much of the stem cell's power resides in the release of a multitude of molecules, called stem cell released molecules(SRM). A fundamentally new type of therapeutic, namely "systems therapeutic", can be realized by reverse engineering the mechanisms of the SRM processes. Recent data demonstrates that the composition of the SRM is different for each type of stem cell, as well as for different states of each cell type. Although systemsbiology has been successfully used to analyze multiple pathways, the approach is often used to develop a small molecule interacting at only one pathway in the system. A new model is emerging in biology where systems biology is used to develop a new technology acting at multiple pathways called "systems therapeutics". A natural set of healing pathways in the human that uses SRM is instructive and of practical use in developing systems therapeutics. Endogenous SRM processes in the human body use a combination of SRM from two or more stem cell types, designated as S2 RM, doing so under various state dependent conditions for each cell type. Here we describe our approach in using statedependent SRM from two or more stem cell types, S2 RM technology, to develop a new class of therapeutics called "systems therapeutics." Given the ubiquitous and powerful nature of innate S2RM-based healing in the human body, this "systems therapeutic" approach using S2 RM technology will be important for the development of anti-cancer therapeutics, antimicrobials, wound care products and procedures, and a number of other therapeutics for many indications.
