Almost everyone is susceptible to the severe acute respiratorysyndrome coronavirus 2(SARS-CoV-2),an RNA virus,which cancause many symptoms and even death among high-risk individu-als[1,2].The main protease(M^(Pro),als...Almost everyone is susceptible to the severe acute respiratorysyndrome coronavirus 2(SARS-CoV-2),an RNA virus,which cancause many symptoms and even death among high-risk individu-als[1,2].The main protease(M^(Pro),also known as 3CL^(Pro))is a cys-teine protease essential for producing infectious virions and thusan attractive target for drug development.Up to now,many studiesusing either in silico ligand docking or drug discovery based onavailable structures have been performed to discover new MPTO.inhibiting agents[3.4].展开更多
基金supported by the Thousand Young Talents Program of Chinathe National Natural Science Foundation of China(31770795,81974514,21961003+8 种基金31971043)the Jiangxi Provincial Natural Science Foundation(20181ACB20014 and20192BAB205114)the Open Project of Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases,Ministry of Education(XN201904)Gannan Medical University(QD201910)Jiangxi"Double Thousand Plan"the Foreign Talent Project of Jiangxi ProvinceTalent Project of Jiangxi ProvinceShenzhen Fundamental Research ProgramGanzhou COVID-19 Emergency Research Project。
文摘Almost everyone is susceptible to the severe acute respiratorysyndrome coronavirus 2(SARS-CoV-2),an RNA virus,which cancause many symptoms and even death among high-risk individu-als[1,2].The main protease(M^(Pro),also known as 3CL^(Pro))is a cys-teine protease essential for producing infectious virions and thusan attractive target for drug development.Up to now,many studiesusing either in silico ligand docking or drug discovery based onavailable structures have been performed to discover new MPTO.inhibiting agents[3.4].
