Alcohol-associated liver disease(ALD)is increasingly prevalent throughout the world(1).It remains the leading cause of liver-related morbidity and mortality worldwide and contributes to approximately 6%of global death...Alcohol-associated liver disease(ALD)is increasingly prevalent throughout the world(1).It remains the leading cause of liver-related morbidity and mortality worldwide and contributes to approximately 6%of global deaths(2).ALD encompasses a wide range of hepatic pathologies,including steatosis,steatohepatitis,fibrosis,and cirrhosis(3).Given the severe lack of therapeutic interventions available to reverse the progression of ALD,it is currently the leading indication for liver transplantation(4).Advancements within the field are needed to identify diagnostic biomarkers for early detection and to develop therapeutics to ameliorate hepatic dysfunction and pathologies associated with ALD.展开更多
基金funded in part by National Institutes of Health grants NIH R21AA026928,R01DK109964,and AA029218(K.S.F)and by NIH/NCATS Colorado CTSA Grant Number TL1 TR002533(C.D.M.).Contents are the authors’sole responsibility and do not necessarily represent official NIH views.
文摘Alcohol-associated liver disease(ALD)is increasingly prevalent throughout the world(1).It remains the leading cause of liver-related morbidity and mortality worldwide and contributes to approximately 6%of global deaths(2).ALD encompasses a wide range of hepatic pathologies,including steatosis,steatohepatitis,fibrosis,and cirrhosis(3).Given the severe lack of therapeutic interventions available to reverse the progression of ALD,it is currently the leading indication for liver transplantation(4).Advancements within the field are needed to identify diagnostic biomarkers for early detection and to develop therapeutics to ameliorate hepatic dysfunction and pathologies associated with ALD.
