Background and Objectives: Three post-marketing clinical follow-up studies were performed in Europe to confirm the safety and performance of four nonprescription, nasal cleansing medical devices: Otrivin Sea Water (OS...Background and Objectives: Three post-marketing clinical follow-up studies were performed in Europe to confirm the safety and performance of four nonprescription, nasal cleansing medical devices: Otrivin Sea Water (OSW) pressurized spray, OSW with aloe vera (OSWAV), Otrisal 0.74% NaCl Metered-Dose Spray (MDS), and Prorhinel spray. Material and Methods: Observational, single-arm, retrospective studies consisting of a single online questionnaire were performed between July 2021 and December 2021. Eligible participants were adults who used the device or supervised use of the device in a participant under 18 years of age within 6 months of completing the questionnaire. Demographics, safety, and device performance were assessed. Results: Based on questionnaires submitted on OSW (n = 556), OSWAV (n = 555), Otrisal MDS (n = 555), and Prorhinel (n = 555), proportions of users who reported safety events were 1.8% for OSW, 2.3% for OSWAV, 1.4% for Otrisal MDS, and 2.0% for Prorhinel. Proportions of users who indicated they were satisfied or very satisfied with device performance ranged from 72.0% - 89.0% across all devices. Device performance for all products was also supported for additional preventative and symptomatic uses through exploratory analyses. Conclusions and Significance: These data confirm device safety and performance of OSW, OSWAV, Otrisal MDS, and Prorhinel for their intended uses.展开更多
Objective:To investigate the antibacterial properties of lucifensin in maggots of IjicUia sericala after septic injury.Mettiods:In our preliminary study we have shown that injuring the maggots with a needle soaked in ...Objective:To investigate the antibacterial properties of lucifensin in maggots of IjicUia sericala after septic injury.Mettiods:In our preliminary study we have shown that injuring the maggots with a needle soaked in lipopolysaccharide solution induced within 24 h lucifensin expression in the fat body and in the grease coupler of the salivary glands.It is assumed that lucifensin is secreted solely from this tissue into the haemoiymph(similar to other insect defensins) and not into secreted/excreted products.We used high-performance liquid chromatography fractionation and radial diffusion assay to investigate the antibacterial properties of haemoiymph extracted from larvae after septic injury.Results:After septic injury,production of lucifensin in the haemoiymph is increased.This led to higher antibacterial activity of such haemoiymph in comparison to non-stimulated larvae.Coclusions:These results suggest that beside the previously demonstrated role of lucifensin in the debridement therapy,lucifensin is simultaneously important as a part of the systematic immune response.展开更多
In this study, dielectric properties within 8-12 GHz microwave frequencies, inductively coupled plasma-atomic emis- sion spectrometry, Fourier transform infrared spectrometry, synchronized two thermal analyses, and 57...In this study, dielectric properties within 8-12 GHz microwave frequencies, inductively coupled plasma-atomic emis- sion spectrometry, Fourier transform infrared spectrometry, synchronized two thermal analyses, and 57Fe Mossbauer spectroscopy analysis of chalcedony, agate, and zultanite samples from Turkey are presented. Agate and chalcedony show the same nine vibrational absorption peaks obtained unlike zultanite from FTIR spectra in the 350 cm-1 to 4000 cm-1 range, ε' values of chalcedony, agate and zultanite derived at 10.5 GHz were 4.67, 4.41, and 7.34, respectively, eI and e~ values of the studied samples at the microwave frequencies are related to the percentage weight of their constituent parts in their chemical compositions. 57Fe Mossbauer spectroscopy results confirm the existence of iron-containing islands in the crystal structure of zultanite, agate, and chalcedony samples, equipped them with magnetic features typical for magnetic nanoparticles including superparamagnetism. The presence of iron-containing islands significantly affects the magnetic, dielectric, and optical properties of studied samples that are not observed for pure minerals without any foreign inclusions.展开更多
文摘Background and Objectives: Three post-marketing clinical follow-up studies were performed in Europe to confirm the safety and performance of four nonprescription, nasal cleansing medical devices: Otrivin Sea Water (OSW) pressurized spray, OSW with aloe vera (OSWAV), Otrisal 0.74% NaCl Metered-Dose Spray (MDS), and Prorhinel spray. Material and Methods: Observational, single-arm, retrospective studies consisting of a single online questionnaire were performed between July 2021 and December 2021. Eligible participants were adults who used the device or supervised use of the device in a participant under 18 years of age within 6 months of completing the questionnaire. Demographics, safety, and device performance were assessed. Results: Based on questionnaires submitted on OSW (n = 556), OSWAV (n = 555), Otrisal MDS (n = 555), and Prorhinel (n = 555), proportions of users who reported safety events were 1.8% for OSW, 2.3% for OSWAV, 1.4% for Otrisal MDS, and 2.0% for Prorhinel. Proportions of users who indicated they were satisfied or very satisfied with device performance ranged from 72.0% - 89.0% across all devices. Device performance for all products was also supported for additional preventative and symptomatic uses through exploratory analyses. Conclusions and Significance: These data confirm device safety and performance of OSW, OSWAV, Otrisal MDS, and Prorhinel for their intended uses.
基金Supported by the Operational Program Research and Development and co-financed by the European Fund for Regional Development(EFRD)via Grant:ITMS 26240220030-"Research and development of new biotherapeutic methods and its application in some illnesses treatment"
文摘Objective:To investigate the antibacterial properties of lucifensin in maggots of IjicUia sericala after septic injury.Mettiods:In our preliminary study we have shown that injuring the maggots with a needle soaked in lipopolysaccharide solution induced within 24 h lucifensin expression in the fat body and in the grease coupler of the salivary glands.It is assumed that lucifensin is secreted solely from this tissue into the haemoiymph(similar to other insect defensins) and not into secreted/excreted products.We used high-performance liquid chromatography fractionation and radial diffusion assay to investigate the antibacterial properties of haemoiymph extracted from larvae after septic injury.Results:After septic injury,production of lucifensin in the haemoiymph is increased.This led to higher antibacterial activity of such haemoiymph in comparison to non-stimulated larvae.Coclusions:These results suggest that beside the previously demonstrated role of lucifensin in the debridement therapy,lucifensin is simultaneously important as a part of the systematic immune response.
基金supported by the Project LO1305 and Operational Program Education for Competitiveness-European Social Fund of the Ministry of Education,Youth and Sports of the Czech Republic(Grant No.CZ.1.07/2.3.00/20.0155)the Internal Student Grant IGA of Palacky University in Olomouc,Czech Republic(Grant No.IGA PrF 2014017)
文摘In this study, dielectric properties within 8-12 GHz microwave frequencies, inductively coupled plasma-atomic emis- sion spectrometry, Fourier transform infrared spectrometry, synchronized two thermal analyses, and 57Fe Mossbauer spectroscopy analysis of chalcedony, agate, and zultanite samples from Turkey are presented. Agate and chalcedony show the same nine vibrational absorption peaks obtained unlike zultanite from FTIR spectra in the 350 cm-1 to 4000 cm-1 range, ε' values of chalcedony, agate and zultanite derived at 10.5 GHz were 4.67, 4.41, and 7.34, respectively, eI and e~ values of the studied samples at the microwave frequencies are related to the percentage weight of their constituent parts in their chemical compositions. 57Fe Mossbauer spectroscopy results confirm the existence of iron-containing islands in the crystal structure of zultanite, agate, and chalcedony samples, equipped them with magnetic features typical for magnetic nanoparticles including superparamagnetism. The presence of iron-containing islands significantly affects the magnetic, dielectric, and optical properties of studied samples that are not observed for pure minerals without any foreign inclusions.