Aims: To investigate whether plasma biomarkers for axonal injury and inflammation are related to loss and recovery of visual function in acute optic neuritis (ON).Methods: Eighteen patientswith ON and 14 controls were...Aims: To investigate whether plasma biomarkers for axonal injury and inflammation are related to loss and recovery of visual function in acute optic neuritis (ON).Methods: Eighteen patientswith ON and 14 controls were investigated in a longitudinal, prospective study. Plasma phosphorylated neurofilament heavy chain (NfHSMI35; a surrogate marker of axonal injury), nitric oxide metabolites (NOx), and citrulline (surrogate markers of inflammation) were measured. Results: Patients with ON had higher median plasma NfHSMI35 values than controls (0.17 versus 0.005 ng/ml; p < 0.05) and higher NOx values (49 versus 35.5μ M; p < 0.001). Plasma NfHSMI35 values correlated inverselywith visual acuity at presentation (R= 0.67; p=0.01). NfHSMI35 was higher in patients with poor recovery of visual acuity than in those with good recovery (0.25 ng/ml versus 0.09 ng/ml; p < 0.05). Three of four patients with high NfHSMI35 and high NOx values experienced a poor recovery as opposed to only one of five with high NOx but normal NfHSMI35 values. Conclusions: NfHSMI35, a surrogate marker for axonal damage, is a prognostic indicator and should be considered in the design of neuroprotective treatment strategies.展开更多
Listeriosis is an infection caused b y the bacterium Listeriamonocytogenes.In pregnancy listeriosis may result in abortion,still -birth,premature d elivery or severe neonatal infection.Clinical manifestations of mater...Listeriosis is an infection caused b y the bacterium Listeriamonocytogenes.In pregnancy listeriosis may result in abortion,still -birth,premature d elivery or severe neonatal infection.Clinical manifestations of maternal lis-teriosis are often influenza -like s ymptoms.We present a case of listeriosis in a triplet pregnancy with abortion of the1st and 2nd fetus and the birth of a healthy 3rd child in the25th week of gestation.展开更多
A new form of nystagmus is described in this paper: optic flow induced nystagmus (OFN). Optic field flow, for example when driving or viewing films on a large screen, triggered nonfatiguable upbeat nystagmus. This t...A new form of nystagmus is described in this paper: optic flow induced nystagmus (OFN). Optic field flow, for example when driving or viewing films on a large screen, triggered nonfatiguable upbeat nystagmus. This type of nystagmus could not be induced by vestibular stimuli, positioning, or self motion. The aetiology and anatomical correlate of OFN remains unknown. Treatment with gabapentin suppressed OFN.展开更多
文摘Aims: To investigate whether plasma biomarkers for axonal injury and inflammation are related to loss and recovery of visual function in acute optic neuritis (ON).Methods: Eighteen patientswith ON and 14 controls were investigated in a longitudinal, prospective study. Plasma phosphorylated neurofilament heavy chain (NfHSMI35; a surrogate marker of axonal injury), nitric oxide metabolites (NOx), and citrulline (surrogate markers of inflammation) were measured. Results: Patients with ON had higher median plasma NfHSMI35 values than controls (0.17 versus 0.005 ng/ml; p < 0.05) and higher NOx values (49 versus 35.5μ M; p < 0.001). Plasma NfHSMI35 values correlated inverselywith visual acuity at presentation (R= 0.67; p=0.01). NfHSMI35 was higher in patients with poor recovery of visual acuity than in those with good recovery (0.25 ng/ml versus 0.09 ng/ml; p < 0.05). Three of four patients with high NfHSMI35 and high NOx values experienced a poor recovery as opposed to only one of five with high NOx but normal NfHSMI35 values. Conclusions: NfHSMI35, a surrogate marker for axonal damage, is a prognostic indicator and should be considered in the design of neuroprotective treatment strategies.
文摘Listeriosis is an infection caused b y the bacterium Listeriamonocytogenes.In pregnancy listeriosis may result in abortion,still -birth,premature d elivery or severe neonatal infection.Clinical manifestations of maternal lis-teriosis are often influenza -like s ymptoms.We present a case of listeriosis in a triplet pregnancy with abortion of the1st and 2nd fetus and the birth of a healthy 3rd child in the25th week of gestation.
文摘A new form of nystagmus is described in this paper: optic flow induced nystagmus (OFN). Optic field flow, for example when driving or viewing films on a large screen, triggered nonfatiguable upbeat nystagmus. This type of nystagmus could not be induced by vestibular stimuli, positioning, or self motion. The aetiology and anatomical correlate of OFN remains unknown. Treatment with gabapentin suppressed OFN.
