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Still elusive: Developments in the accurate diagnosis of indeterminate biliary strictures
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作者 Lynn Affarah philip berry Sreelakshmi Kotha 《World Journal of Gastrointestinal Endoscopy》 2024年第6期297-304,共8页
Indeterminate biliary strictures pose a significant diagnostic dilemma for gastroenterologists.Despite advances in endoscopic techniques and instruments,it is difficult to differentiate between benign and malignant pa... Indeterminate biliary strictures pose a significant diagnostic dilemma for gastroenterologists.Despite advances in endoscopic techniques and instruments,it is difficult to differentiate between benign and malignant pathology.A positive histological diagnosis is always preferred prior to high risk hepatobiliary surgery,or to inform other types of therapy.Endoscopic retrograde cholangiopancreato-graphy with brushings has low sensitivity and despite significant improvements in instruments there is still an unacceptably high false negative rate.Other methods such as endoscopic ultrasound and cholangioscopy have improved diagnostic quality.In this review we explore the techniques available to aid accurate diagnosis of indeterminate biliary strictures and obtain accurate histology to facilitate clinical management. 展开更多
关键词 Indeterminate biliary stricture Benign biliary stricture Malignant biliary stricture Endoscopic retrograde cholangiopancreatography Endoscopic ultrasound Primary sclerosing cholangitis
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Hepatic, pancreatic and renal manifestations of a ciliopathy
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作者 Sreelakshmi Kotha philip berry 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2021年第4期394-395,共2页
Hepatorenal fibrocystic diseases are inherited disorders,characterized by developmental abnormalities and fibrocystic degeneration of the portobiliary system and kidneys^([1]).They are part of a larger group of disord... Hepatorenal fibrocystic diseases are inherited disorders,characterized by developmental abnormalities and fibrocystic degeneration of the portobiliary system and kidneys^([1]).They are part of a larger group of disorders referred to as"ciliopathies"which affect 1 in 1000 people.Polycystic kidney disease is the most common kidney manifestation,while others include nephronophthisis,glomerulocystic disease and cystic dysplasia.Hepatic manifesta-tions include Caroli’s disease,congenital hepatic fibrosis and poly-cystic liver disease. 展开更多
关键词 HEPATIC kidney DEGENERATION
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