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Controversies in the management of primary sclerosingcholangitis 被引量:1
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作者 Jeremy S Nayagam Stephen P Pereira +2 位作者 John Devlin phillip m harrison Deepak Joshi 《World Journal of Hepatology》 CAS 2016年第5期265-272,共8页
Primary sclerosing cholangitis(PSC) remains a rare but significant disease, which affects mainly young males in association with inflammatory bowel disease. There have been few advances in the understanding of the pat... Primary sclerosing cholangitis(PSC) remains a rare but significant disease, which affects mainly young males in association with inflammatory bowel disease. There have been few advances in the understanding of the pathogenesis of the condition and no therapeutics with proven mortality benefit aside from liver transplantation. There remain areas of controversy in the management of PSC which include the differentiation from other cholangiopathies, in particular immunoglobulin G4 related sclerosing cholangitis, the management of dominant biliary strictures, and the role of ursodeoxycholic acid. In addition, the timing of liver transplantation in PSC remains difficult to predict with standard liver severity scores. In this review, we address these controversies and highlight the latest evidence base in the management of PSC. 展开更多
关键词 IMMUNOGLOBULIN G4 related sclerosingcholangitis CHOLANGIOCARCINOMA PRIMARY sclerosingcholangitis Liver transplantation Dominant STRICTURES
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