Understanding DNA methylation(DNAm)alterations in tumors is important to develop novel therapeutic targets and powerful biomarkers,and to gain insights into tumorigenesis processes.As many studies have highlighted the...Understanding DNA methylation(DNAm)alterations in tumors is important to develop novel therapeutic targets and powerful biomarkers,and to gain insights into tumorigenesis processes.As many studies have highlighted the confounding effects of tumor purity in DNAm analyses,1,2,3 various tools have also been developed to tackle the issue.2,3,4 Among them,InfiniumPurify R package is a popular and widely cited tool,2,3,5 consisting of a set of statistical methods to estimate and account for tumor purity in cancer DNAm analyses.展开更多
基金This work was supported by the Intramural Research Program,Division of Cancer Epidemiology and Genetics,National Cancer Institute,National Institutes of Health,USA.
文摘Understanding DNA methylation(DNAm)alterations in tumors is important to develop novel therapeutic targets and powerful biomarkers,and to gain insights into tumorigenesis processes.As many studies have highlighted the confounding effects of tumor purity in DNAm analyses,1,2,3 various tools have also been developed to tackle the issue.2,3,4 Among them,InfiniumPurify R package is a popular and widely cited tool,2,3,5 consisting of a set of statistical methods to estimate and account for tumor purity in cancer DNAm analyses.
