Background:Anti-neutrophil antibodies are a wellrecognized cause of neutropenia,producing a potential increase in risk of infection:in the majority of patients antibodies react against antigens located on the IgG Fc r...Background:Anti-neutrophil antibodies are a wellrecognized cause of neutropenia,producing a potential increase in risk of infection:in the majority of patients antibodies react against antigens located on the IgG Fc receptor type 3b(FcRIIIb),but other target antigens have been identified.Data sources:In this review the most important papers of auto and alloimmune neutropenias of infancy and childhood were analyzed.PubMed,Google Scholar and Thompson ISI Web of Knowledge were searched for identifying relevant papers.Results:Primary autoimmune neutropenia of infancy is mostly a benign condition with self-limited course,whereas isolated alloimmune neonatal neutropenia or secondary autoimmune neutropenia may be occasionally complicated by severe infections.Conclusion:Granulocyte colony stimulating factor is an effective therapy for patients affected by all types of autoimmune and alloimmune neutropenia,even though most of them do not need any therapy.展开更多
文摘Background:Anti-neutrophil antibodies are a wellrecognized cause of neutropenia,producing a potential increase in risk of infection:in the majority of patients antibodies react against antigens located on the IgG Fc receptor type 3b(FcRIIIb),but other target antigens have been identified.Data sources:In this review the most important papers of auto and alloimmune neutropenias of infancy and childhood were analyzed.PubMed,Google Scholar and Thompson ISI Web of Knowledge were searched for identifying relevant papers.Results:Primary autoimmune neutropenia of infancy is mostly a benign condition with self-limited course,whereas isolated alloimmune neonatal neutropenia or secondary autoimmune neutropenia may be occasionally complicated by severe infections.Conclusion:Granulocyte colony stimulating factor is an effective therapy for patients affected by all types of autoimmune and alloimmune neutropenia,even though most of them do not need any therapy.
