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基于Tei指数评价蒽环类药物对急性白血病患儿心脏毒性的研究
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作者 陈雪梅 郭品 +3 位作者 钏刘芳 王梓 李雪娇 何文姬 《昆明医科大学学报》 CAS 2024年第2期117-122,共6页
目的应用超声技术监测急性白血病患儿使用蒽环类药物后的心功能,以期得到心功能早期变化的指标。方法按照入组与排除标准选取2018年3月至2020年12月昆明医科大学附属儿童医院白血病患儿,记录其常规心脏超声指标和组织多普勒,并应用TeiS... 目的应用超声技术监测急性白血病患儿使用蒽环类药物后的心功能,以期得到心功能早期变化的指标。方法按照入组与排除标准选取2018年3月至2020年12月昆明医科大学附属儿童医院白血病患儿,记录其常规心脏超声指标和组织多普勒,并应用TeiS、TeiRL、TeiM和TeiT评估心脏收缩功能的变化。结果正常组和用药前实验组常规心脏超声指标中LVEF的均值都在60%以上,FS、SV及EDV均在正常范围,常规指标、TDI和Tei指数无统计学意义(P>0.05);实验组累积剂量为200和250 mg/m^(2)组的TeiM与用药前存在显著差异(P<0.05);200和250 mg/m^(2)组与用药前的TeiRL存在显著差异(P<0.05);200和250 mg/m^(2)组与用药前的TeiT存在显著差异(P<0.05)。结论Tei指数可作为白血病患儿应用蒽环类药物后左右心功能的早期改变较敏感监测指标。 展开更多
关键词 蒽环类药物 心脏毒性 超声心动图 室间隔基底段心肌做功指数 右室侧壁基底心肌做功指数 左心心肌做功指数
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Dynamic expression of cerebral cortex and hippocampal glutamate transporters in a rat model of chest compression-induced global cerebral ischemia
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作者 Qinhua guo Jin Lan +4 位作者 Weiqiao Zhang pin guo Liemei guo Zhiqiang Li Yongming Qiu 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第2期125-130,共6页
The present study established a rat model of global cerebral ischemia induced by chest compression for six minutes to dynamically observe expressional changes of three glutamate transporters in the cerebral cortex and... The present study established a rat model of global cerebral ischemia induced by chest compression for six minutes to dynamically observe expressional changes of three glutamate transporters in the cerebral cortex and hippocampus. After 24 hours of ischemia, expression of glutamate transporter-1 significantly decreased in the cerebral cortex and hippocampus, which was accompanied by neuronal necrosis. At 7 days post-ischemia, expression of excitatory amino acid carrier 1 decreased in the hippocampal CA1 region and cortex, and was accompanied by apoptosis Expression of glutamate-aspartate transporter remained unchanged at 6 hours 7 days after ischemia. These results suggested that glutamate transporter levels were altered at different periods of cerebral ischemia. 展开更多
关键词 apoptosis excitatory amino acid carrier 1 global cerebral ischemia glutamate-aspartate transporter glutamate transporter glutamate transporter-1 NEUROPROTECTION
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视觉与惯性融合的多旋翼飞行机器人室内定位技术 被引量:2
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作者 张怀捷 马静雅 +4 位作者 刘浩源 郭品 邓慧超 徐坤 丁希仑 《航空学报》 EI CAS CSCD 北大核心 2023年第5期292-304,共13页
随着人工智能技术的发展,无人机的应用场景趋向多元,人们对无人机的需求也不仅仅满足于简单的飞行任务,而是赋予其飞行机器人的角色,对其自主导航、复杂环境下的定位以及智能协同方面提出了更高的要求。针对室内场景下的定位需求,融合... 随着人工智能技术的发展,无人机的应用场景趋向多元,人们对无人机的需求也不仅仅满足于简单的飞行任务,而是赋予其飞行机器人的角色,对其自主导航、复杂环境下的定位以及智能协同方面提出了更高的要求。针对室内场景下的定位需求,融合视觉与惯性数据实现了多旋翼飞行机器人的室内定位。在视觉前端加入图像增强算法以提高图像灰度对比度,减少了光流跟踪的误匹配点数。提出了一种基于图像信息的特征点提取和图像帧发布策略提高了定位精度,解决了室内环境下的定位漂移问题。针对飞行机器人室内自主跟踪及降落任务,设计了基于视觉定位的飞行机器人自主降落系统。在Gazebo中搭建飞行机器人模型仿真验证自主降落系统有效性,在EuRoC数据集下对定位算法进行对比评估,搭建飞行机器人平台在真实场景下进行室内定位实验,完成了室内场景下平台自主跟踪及降落任务,并采用运动捕捉系统获取的定位真值数据进行了误差分析,结果表明该定位技术满足室内场景下的自主跟踪及降落任务需求。 展开更多
关键词 飞行机器人 室内定位 自主跟踪及降落 传感器数据融合 视觉导航
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A review of aerial manipulation of small-scale rotorcraft unmanned robotic systems 被引量:21
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作者 Xilun DING pin guo +1 位作者 Kun XU Yushu YU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2019年第1期200-214,共15页
Small-scale rotorcraft unmanned robotic systems(SRURSs) are a kind of unmanned rotorcraft with manipulating devices. This review aims to provide an overview on aerial manipulation of SRURSs nowadays and promote relati... Small-scale rotorcraft unmanned robotic systems(SRURSs) are a kind of unmanned rotorcraft with manipulating devices. This review aims to provide an overview on aerial manipulation of SRURSs nowadays and promote relative research in the future. In the past decade, aerial manipulation of SRURSs has attracted the interest of researchers globally. This paper provides a literature review of the last 10 years(2008–2017) on SRURSs, and details achievements and challenges. Firstly, the definition, current state, development, classification, and challenges of SRURSs are introduced. Then, related papers are organized into two topical categories: mechanical structure design, and modeling and control. Following this, research groups involved in SRURS research and their major achievements are summarized and classified in the form of tables. The research groups are introduced in detail from seven parts. Finally, trends and challenges are compiled and presented to serve as a resource for researchers interested in aerial manipulation of SRURSs. The problem,trends, and challenges are described from three aspects. Conclusions of the paper are presented,and the future of SRURSs is discussed to enable further research interests. 展开更多
关键词 AERIAL MANIPULATION Mechanical structure design Modeling and control Research GROUPS SMALL-SCALE ROTORCRAFT unmanned AERIAL systems TRENDS and challenges
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Structural Deleveraging: Evidence from China 被引量:1
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作者 Caoyuan Ma pin guo Zhao Zhang 《China & World Economy》 2022年第6期137-162,共26页
Using province-level data in China for the period of 1999-2015,we examine the mechanisms through which sectoral differences in leverage ratio and productivity affect macro leverage ratios.The state-owned sector undert... Using province-level data in China for the period of 1999-2015,we examine the mechanisms through which sectoral differences in leverage ratio and productivity affect macro leverage ratios.The state-owned sector undertakes a large number of public services and plays an irreplaceable role in solving market failures and providing public goods.However,in the case of information asymmetry and incentive incompatibility,these policy burdens affect the leverage optimization and productivity improvement of the state-owned sector.From the perspective of sectoral differences,we therefore decompose the change in macro leverage ratio into leverage ratio structure effect and productivity structure effect,and then substantiate the impact mechanisms of these two effects on macro leverage ratios.Overall,our conclusions provide theoretical support and empirical evidence for structural deleveraging in China. 展开更多
关键词 macro leverage ratio sectoral difference structural deleveraging total factor productivity
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