Mapping out the reaction network of humin formation at the initial stage of fructose dehydration in water

The formation of humins hampers the large-scale production of 5-hydroxymethylfurfural(HMF)in biorefinery.Here,a detailed reaction network of humin formation at the initial stage of fructose-to-HMF dehydration in water is delineated by combined experimental,spectroscopic,and theoretical studies.Three bimolecular reaction pathways to build up soluble humins are demonstrated.That is,the intermolecular etherification of β-furanose at room temperature initiates the C12 path,whereas the C-C cleavage of a-furanose at 130-150℃ leads to C11 path,and that of open-chain fructose at 180℃ to C11' path.The successive intramolecular dehydrations and condensations of the as-formed bimolecular intermediates lead to three types of soluble humins.We show that the C12 path could be restrained by using HCl or AlCl_(3) catalyst,and both the C12 and C110 paths could be effectively inhibited by adding THF as a co-solvent or accelerating heating rate via microwave heating.

综合有机合成实验苯佐卡因的课程思政设计

将传统的合成路线和条件都给定的综合有机实验“苯佐卡因的合成”,改造成路线可设计、条件可优化的创新性实验。学生通过文献调研、综合分析以及评估合成策略和具体实验条件,提出兼顾宏观(路线)和微观(具体条件)的改进实验方案,规避原实验的局限性和不足。根据学生专业和培养方案的不同,开放部分或全部“权限”给学生,从不同层级原料出发,设计绿色、高效的合成路线,确定具体的实验方案;或根据建议路线,调整和优化实验条件,使学生在得到基础实验操作技能训练的基础上,其绿色、高效、可持续发展的合成理念也得到进一步升华。鼓励学生运用科学思维,将学科前沿成果引入实验实践中,培养学生科学创新能力。引导学生从全局出发,提升团队合作意识和能力。

Effect of fermented Rosa roxburghii Tratt fruit juice on gut microbiota in a dextran sulfate sodium-induced colitis mouse model

This study mainly investigated the regulatory effect of Rosa roxburghii Tratt fruit juice fermented by Lacticaseibacillus paracasei SR10-1(LAB-RRTJ)on modulating gut microbiota in dextran sulfate sodium(DSS)-induced ulcerative colitis in mice.Compared to control group,DSS induction decreased body weight of mice,indexes of Shannon,Simpson,Chao1 and Faith_pd,and increased disease activity index(DAI)and levels of interleukin 1β(IL-1β),IL-6,tumor necrosis factorα(TNF-α)and interferon-γ(IFN-γ);And this induction also led to an increase in Proteobacteria,Verrucomicrobia and Actinobacteria at phylum level,harmful bacterial species richness at genus level,and relative richness of S.sciuri,Desulfovibrio C21_c20,R.gnavus and Akkermansia muciniphila at species level,and a decrease in Firmicutes at phylum level and relative richness of B.acidifaciens in mice.LAB-RRTJ increased body weight of mice with DSS induced ulcerative colitis(UC)and indexes of Shannon,Simpson,Chao1 and Faith_pd,reduced DAI and the content of four infl ammatory factors and improved gut microbiota imbalance in DSS induced UC mice.Besides,the number of operational taxonomic units(OTUs)increased,α-diversity andβ-diversity were restored and similar to those in mice in the control group after LAB-RRTJ treatment.Compared with the positive drug treatment group,LAB-RRTJ has a better effect on regulating gut microbiota diversity in colitis mice.Correlation analysis showed that infl ammatory factors were positively correlated with harmful bacteria and negatively correlated with beneficial bacteria which commonly found in some colitis mice.Taken together,our study demonstrated that LAB-RRTJ could alleviate DSS-induced colitis in mice through the modulation of infl ammatory cytokines and gut microbiota composition.

基于脂质组学的敏感性皮肤表面脂质差异分析

建立了基于脂质组学技术的人面部皮肤表面脂质采集、检测及分析方法,用于敏感性皮肤脂质代谢紊乱的研究。首先通过乳酸刺痛实验将青年女性志愿者分为敏感性皮肤组和非敏感性皮肤组,检测其生理指标并采集面部皮肤表面脂质进行超高效液相色谱-四极杆-飞行时间质谱(UPLC-Q-TOF-MS)分析。随后,运用正交偏最小二乘-判别分析(OPLS-DA)结合t检验筛选出差异性成分并进行精准二级质谱鉴定,共指认出29种甘油三酯类(TG)差异性脂质。与非敏感性皮肤组相比,敏感性皮肤组中这些差异性TG的水平显著降低,并对相关生物学意义进行了阐述。本研究为敏感性皮肤发生机制的探索及相关护肤品的研发提供了理论指导和技术支撑。

Crosstalk between nano/micro particulate technologies and Chinese medicine: a bibliometric analysis

Background:Chinese medicine is widely applied in Asian and Western countries for its outstanding therapeutic effect,but there are still unsolved problems such as unclear active ingredients and pharmacological effects.The application of nano/microparticle technology in Chinese medicine may become a promising strategy to solve this problem in the near future(provided that more efforts are made to in-depth exploration).In this work,a comprehensive analysis of the field was carried out from a bibliometrics perspective,and further the publishing trends and research hotspots were figured out.Methods:The articles or reviews from 2000 to 2020 were retrieved in the database of Web of Science Core Collection.The documents were processed by Clarivate Analytic,Visualization of Similarities viewer,Statistical Analysis Toolkit for Informetrics and bibliometric online platform,and the data were visualized.Finally,a bibliometric summary,citation analysis results and research trends were described.Results:A bibliometric analysis of 773 articles of interest showed that research in this field had continued to grow in recent years,with a high degree of interdisciplinary integration.Secondly,this field attached great importance to the quantitative analysis of Chinese medicine combined with nano/micro particle technology.Chinese medicine,nanoparticles and liposomes were the most accessed keywords.China was the main contributing country,and the top-10 contributing organizations were all located in China.Co-authorship was a common phenomenon in this field.Conclusion:The published literature on the application of nano/micro particle technology in Chinese medicine was summarized.The results suggested that bibliometric analysis could predict possible directions for future research in this field.

Low-dimensional perovskite modified 3D structures for higher-performance solar cells

For solution prepared perovskite solar cells,metal halide perovskite materials with low-dimensional(LD)are flexibly employed in 3D perovskite solar cells to promote efficiency and long-term stability.In this review,the various structures,properties,and applications of LD perovskites are firstly summarized and discussed.To take advantage of LD materials,LD perovskites are introduced in the 3D bulk and/or the interface between the perovskite thin film and the carrier transporting layer to passivate the gain boundary defects while providing the stability advantage of LD materials.Therefore,the preparation methods and crystallization control of the LD perovskite layers are discussed in depth.Then,the combined devices using both LD and 3D components are reviewed on the basis of device design,cell structure,interface charge transfer,energy lever alignment,and synergistic improvement of both efficiency and stability.Finally,the challenges and expectations are speculated for further development of perovskite solar cells.

Peridynamic Shell Model Based on Micro-Beam Bond

Peridynamics(PD)is a non-localmechanics theory that overcomes the limitations of classical continuummechanics(CCM)in predicting the initiation and propagation of cracks.However,the calculation efficiency of PDmodels is generally lower than that of the traditional finite elementmethod(FEM).Structural idealization can greatly improve the calculation efficiency of PD models for complex structures.This study presents a PD shell model based on the micro-beam bond via the homogenization assumption.First,the deformations of each endpoint of themicro-beam bond are calculated through the interpolation method.Second,the micro-potential energy of the axial,torsional,and bending deformations of the bond can be established from the deformations of endpoints.Finally,the micro moduli of the shellmodel can be obtained via the equivalence principle of strain energy density(SED).In addition,a new fracture criterion based on the SED of the micro-beam bond is adopted for crack simulation.Numerical examples of crack propagation are provided,and the results demonstrate the effectiveness of the proposed PD shell model.

Using non-destructive sampling to evaluate the population genomic status of captive Brown Eared Pheasants

Evaluating the genetic status of threatened species is an essential task in conservation genetics.However,the genetic status of threatened species has been mostly evaluated through techniques that fail to estimate genetic diversity at the whole genomic level.Next generation sequencing can meet this demand,but high quality samples such as blood or muscle tissues are required.However,it is difficult to collect such samples from threatened species because sampling work may impact their health.Therefore,it is essential to design a workflow to evaluate the whole genomic status of threatened species using non-destructive sampling.Even though non-destructive sampling has been used in traditional barcoding technique,the barcoding technique cannot evaluate the whole genomic status.Brown Eared Pheasant(Crossoptilon mantchuricum)is an endangered species,with captive populations maintained in Taiyuan Zoo,China,and Europe.However,the genetic diversity,inbreeding pattern,and mutation load of these two populations are unclear.To uncover the genetic status of these two captive populations,we applied 2b-RAD technology to evaluate the genomic status of these populations using feathers as samples.The feathers could be collected by non-destructive sampling.The results indicate that the Taiyuan Zoo population has a lower genetic diversity and higher inbreeding coefficient than the European population.The Taiyuan Zoo population has lethal mutations when homozygous.The current project uses a non-destructive sampling technique to evaluate the whole genomic status of the two captive populations,providing a paradigm for conservation genetics,which will facilitate the development of conservation biology.

青光眼小鼠基因模型的研究进展

青光眼作为目前全球首位不可逆性致盲眼病,是具有遗传倾向的多因素复杂疾病,病理性眼压升高是其危险因素。关于青光眼的发病机制尚不完全清楚,现有研究多建立在动物模型的基础上,以小鼠为主要研究对象,通过实验诱导手段或转基因操作复建青光眼病理损伤过程,进一步研究相关的发病机制和病理变化。实验诱导构建青光眼小鼠模型技术经过诸多学者的研究,逐渐趋于成熟。而随着分子生物学和遗传学的研究深入,越来越多的研究集中在青光眼的相关疾病基因上,转基因小鼠模型成为近年的热点,与实验操作控制单一因素相比,基因编辑更能模拟出疾病发病的复杂过程。本文主要通过阐述相关青光眼小鼠转基因模型的研究进展,为今后研究中模型的选择提供更完整的方向与策略。

Mitigating the dissolution of V_(2)O_(5) in aqueous ZnSO_(4) electrolyte through Ti-doping for zinc storage

Aqueous zinc-ion batteries(AZIBs)have become a hotspot for electrochemical energy storage owing to the high safety,low cost,environmental friendliness,and favorable rate performance.However,the serious dissolution of cathode materials in aqueous electrolytes would lead to poor cyclability,which should be addressed before commercialization.Herein,we designed a Ti-doped V_(2)O_(5) with yolk-shell microspherical structure for AZIBs.The Ti doping stabilizes the crystal structure and relieves the dissolution of V_(2)O_(5) in aqueous ZnSO_(4) electrolyte.The optimized sample,Ti_(0.2)V_(1.8)O_(4.9),delivers a high capacity(355 mAh/g at 0.05 A/g)as well as good capacity retention(89%after 2500 cycles at 1.0 A/g).This work provides an effective strategy to mitigate the dissolution of cathode material in aqueous ZnSO_(4) electrolyte for cyclability enhancement.

早期近端胃癌行腹腔镜辅助下近端胃切除双通路吻合术的短期手术疗效观察

目的为评估早期近端胃癌保功能手术的可行性与益处,比较早期胃癌患者行腹腔镜辅助近端胃切除双通道吻合术与腹腔镜辅助全胃切除Roux-en-Y消化道重建术的短期手术效果。方法选取2016年5月-2018年5月29例早期近端胃癌患者接受近端胃切除双通道吻合术;同时选取该院2015年6月以来行全胃切除Roux-en-Y消化道重建术的早期近端胃癌患者,做人口统计学信息、合并症、肿瘤特征和TNM分期配对,对两组患者的围术期和短期手术结果进行比较。结果两组患者的术后病理学特征相近,两组患者均无中转开腹及均未出现术中并发症,两组患者手术时间、术中出血量、术后肛门首次排气时间、首次进食时间及术后住院时间比较,差异均无统计学意义,双通道组淋巴结清扫量(16.73±5.68)枚明显少于全胃切除组(21.43±4.09)枚,两组比较,差异有统计学意义(P=0.023)。每组患者均无吻合口瘘、吻合口出血、反流性食管炎、切口感染及淋巴瘘的记录,两组患者并发症发生率和围术期炎症反应比较,差异无统计学意义。术后随访3个月发现,较之全胃切除Roux-en-Y消化道重建术患者,近端胃切除双通道吻合术患者生活满意度高,两组患者术后体重均较术前下降,其中全胃切除组患者术后体重下降较双通道组比例更高,两组比较,差异有统计学意义(P<0.05);两组患者术前和术后1个月血红蛋白比较,差异无统计学意义,术后2和3个月随访结果显示,双通道组血红蛋白量较全胃切除组高,两组比较,差异有统计学意义(P<0.05);在术前、术后1及2个月,两组患者的血清白蛋白量比较,差异无统计学意义,术后3个月时,双通道组患者血清白蛋白量(41.45±3.68)g/L明显高于全胃切除组(38.45±4.96)g/L,差异有统计学意义(P=0.035)。结论早期近端胃癌行腹腔镜辅助下近端胃切除双通道吻合术有较好的可行性和安全性,近期疗效满意,与全胃切除组比较,双通路术式不增加围术期并发症的发生率,而患者术后营养状况更好,术后体重下降率更低。

我院2011—2016年革兰阳性菌耐药监测数据研究

目的通过对我院2011—2016年住院和门诊患者革兰阳性菌分离比例、耐药情况的分析研究,掌握耐药流行趋势,为抗生素的合理使用提供参考依据。方法对2011年1月—2016年12月本院住院与门诊患者等各种标本进行分离培养,采用全自动细菌鉴定仪和API手工鉴定系统进行细菌鉴定,参照美国临床实验室标准化委员会(CLSI)文件M100-S26标准进行药敏试验和结果判定;后将6年的数据用Whonet 5.6中文版软件及SPSS 13.0软件进行数据统计分析。结果 2011—2016年共分离的革兰阳性菌15,123株占总分离细菌数50,412株的29.99%;其中金黄色葡萄球菌、肺炎链球菌、表皮葡萄球菌、粪肠球菌、屎肠球菌、β-溶血链球菌、草绿色链球菌群排名前7位,分别占总细菌的6.48%~7.78%、5.05%~6.47%、1.25%~2.08%,0.91%~1.26%、0.62%~1.02%,0.55%~1.05%和0.60%~1.01%,无统计学差异(P>0.05)。趋势图显示β-溶血链球菌、草绿色链球菌分离比例有逐步上升趋势;从2014—2016年粪肠球菌出现下降趋势,屎肠球菌出现上升趋势,到2016年屎肠球菌比例高于粪肠球菌比例;耐甲氧西林表皮葡萄球菌(methicillin resistant Staphylococcus epidermidis,MRSE)比例在52.30%~77.60%之间,耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus,MRSA)比例在32.20%~46.80%之间,都有逐年升高趋势;耐青霉素的肺炎链球菌比例在1.70%~3.10%之间;未发现耐万古霉素和利奈唑胺的金黄色葡萄球菌和表皮葡萄球菌,金黄色葡萄球菌对四环素、环丙沙星、左氧氟沙星耐药率有一定下降趋势;肠球菌耐药性相对比较稳定。肺炎链球菌对红霉素、克林霉素、复方磺胺甲噁唑、四环素耐药率较高;草绿色链球菌对氨苄西林、头孢噻肟耐药率呈逐年上升趋势;β-溶血链球菌对常见抗生素保持高敏感性,但是近年出现了对左氧氟沙星的耐药菌株。结论革兰阳性菌分离比例比较稳定,β-溶血链球菌、草绿色链球菌、屎肠球菌分离比例有逐年上升趋势。MRSA比例高于全国平均水平,MRSE比例低于全国平均水平,但都有上升趋势。青霉素耐药肺炎链球菌(penicillin resistant Streptococcus pneumoniae,PRSP)和耐万古霉素肠球菌(vancomycin resistant Enterococcus,VRE)比例保持在全国较低水平。金黄色葡萄球菌耐药性不稳定,变化较大;表皮葡萄球菌耐药性相对稳定。两种葡萄球菌对氟喹诺酮类药物保持较低耐药率,并有逐年下降趋势,肺炎链球菌对头孢噻肟的耐药率逐年上升;多重耐药的草绿色链球菌逐年增加。加强本院或本地区范围内的耐药监测数据研究,发现本地细菌耐药特点更有利于指导临床合理使用抗菌药物。

通过实验教学加深对理论知识的理解——以“气相色谱实验”教学为例

仪器分析是化学专业学生的必修课,其中涉及的基本概念原理比较抽象、难以理解。将理论知识与实验教学相结合可加深学生对理论知识的理解。本文以气相色谱实验为例,通过研究实验条件如柱温、载气流量、进样量以及毛细管气相色谱分流比对分离度的影响,帮助学生理解书本知识,同时也培养了学生科研思维以及分析问题、解决问题的能力。

浅谈几种同分异构体的质谱解析

质谱解析是波谱分析课程教学的重点和难点,有机化合物裂解规则是质谱解析的关键,掌握有机化合物质谱的碎裂规律对于化合物结构解析很有帮助。本文从本科教学的实际出发,对三类常见同分异构体羧酸-酯、醇-醚及直链-支链化合物的质谱碎裂规律进行梳理,并通过具体质谱解析实例帮助学生学习、掌握有机化合物的基本裂解规律,提高质谱解析能力。

支架联合抽吸取栓术治疗老年颅内大血管急性闭塞的疗效观察

目的探讨支架联合抽吸取栓术治疗老年颅内大血管急性闭塞的效果及对患者血流动力学、神经功能和预后的影响。方法选取2016年10月—2019年10月宿州市第一人民医院和贵州医科大学附属医院收治的老年颅内大血管急性闭塞患者62例,按照随机数字表法分为观察组和对照组,每组31例。对照组采用单纯支架取栓,观察组采用支架联合抽吸取栓。比较两组静脉和动脉再通时间和取栓次数;术前和术后3个月神经功能缺损(CSS)评分、Barthel指数量表(BI)评分、颈动脉最小血流量(Qmin)和最小血流速度(Vmin)变化;以及术后3个月预后情况。结果观察组静脉和动脉再通时间长于对照组(P<0.05),取栓次数少于对照组(P<0.05)。观察组手术前后CSS评分、BI评分的差值大于对照组(P<0.05)。观察组手术前后颈动脉Qmin和Vmin的差值大于对照组(P<0.05)。观察组预后良好率高于对照组(P<0.05)。结论支架联合抽吸取栓术治疗老年颅内大血管急性闭塞疗效较好,可改善患者血流动力血管、神经功能及预后。

华东理工大学应用化学一流专业建设的思考与实践

建设高水平本科教育、全面提高人才培养能力,实施一流本科专业“双万计划”具有重要意义。华东理工大学应用化学专业自1985年成立以来,形成了鲜明的专业特色,本文从专业培养目标定位、专业综合改革措施等方面总结了专业改革的思路、实践的经验和取得的成效,并指出了专业建设的不足和持续改进的方向。

后腹腔镜肾实质切开取石术治疗肾脏铸形结石(附23例报告)

目的探讨后腹腔镜技术处理肾脏铸形结石的手术要点与临床应用价值。方法 2013年8月-2017年10月,对23例不适合经皮肾镜取石术(PCNL)的患者给予后腹腔镜肾实质切开取石,结石均为单侧,至少占据一个肾盏和全部肾盂,平均直径2.8(2.3~3.8)cm。术中阻断肾动脉后,经吸引器注入冰水给予肾表面降温,沿Brodel线切开肾实质取出结石,根据肾实质厚度以QuillTM双向倒刺线进行全层或分层连续缝合关闭创缘。结果 23例手术均获成功。手术时间75~135 min,中位数95 min;肾脏热缺血时间17~35 min,中位数25 min;术中估计失血量25~350 ml,中位数105 ml,术中术后均未输血。术后5例出现血尿,均在3.0 d后消失;另有3例出现漏尿,于术后3.0~5.0 d消失。术后复查无明显残石。术后平均随访10(2~18)个月,静脉尿路造影(IVU)显示患肾梗阻程度明显减轻。结论后腹腔镜肾实质切开取石术是一种安全、有效的微创手术方法,对于不适合行PCNL的患者,有望作为PCNL的替代治疗措施,但需进一步增加例数并观察远期疗效。

家族性腺瘤性息肉病47例临床分析

目的探讨家族性腺瘤性息肉病(familial adenomatous polyposis,FAP)的临床表现、病理特征、癌变危险因素及治疗方法 .方法收集江苏省人民医院47例家族性腺瘤性息肉病患者的临床资料,回顾分析其临床表现、病理特征、癌变情况及治疗方法 .结果 47例患者中29例患者表现为黑便或便血,22例发生大便性状改变,腹痛16例,腹胀11例,9例患者伴发胃息肉,4例伴发十二指肠息肉,2例术后发生硬纤维瘤.病理结果以管状腺瘤及绒毛管状腺瘤为主,少数表现为增生性息肉或幼年性息肉.16例患者发生癌变,发现年龄≥40岁及腺瘤直径>2 cm者与40岁以下及腺瘤小于2 cm的患者癌变差异有统计学意义(P<0.05),年龄(OR=1.084,95%CI:1.016-1.157)及腺瘤大小(OR=10.264,95%CI:1.526-69.035)为影响FAP癌变的危险因素.所有患者均行结直肠切除或内镜下治疗,4例癌变患者术后辅以化疗.结论家族性腺瘤性息肉病以结直肠生长大量息肉为主要特征,可伴有一系列肠外表现.病理表现以管状腺瘤及绒毛管状腺瘤为主.发现年龄及腺瘤大小为影响FAP癌变的危险因素.预防性结直肠切除和内镜下监测仍然是目前治疗FAP的主要措施.

家庭养育环境和养育者共心力对婴儿气质的影响

为了探索家庭养育环境和养育者共心力对婴儿气质的影响,本研究采用结构式观察法,对42个家庭的母亲和祖辈的共心力进行测量,并采用母亲报告的问卷法测量婴儿气质。结果发现,与非共同养育环境下的婴儿相比,共同养育环境下的婴儿活动性水平和舒适性水平更高;共同养育环境下的母亲“合适心理评论”与婴儿气质中的“新异刺激引起的负性情绪”显著负相关,非共同养育环境下未发现类似的关系;共同养育环境下的祖辈“合适心理评论”通过母亲“合适心理评论”的中介作用间接影响婴儿气质中的“新异刺激引起的负性情绪”。祖辈参与下的共同养育虽然不直接影响婴儿气质,但由于能够分担育儿压力,所以有利于母亲与婴儿之间的良好联结。促进祖辈与父母对婴儿的共同养育及他们之间的和谐相处,提高母亲的共心力水平,可以为婴儿气质发展创设更好的家庭养育环境。

乌司他丁对百草枯中毒患者肺纤维化程度及近期生存情况的影响

目的:探讨乌司他丁对百草枯中毒患者肺纤维化程度及近期生存情况的影响。方法:选择90例百草枯中毒患者,随机分为两组,对照组45例采用常规治疗,干预组45例在常规治疗的基础上给予乌司他丁治疗5 d。治疗后7 d,对两组患者治疗前后促炎细胞因子[白细胞介素-18(IL-18)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、高迁移率族蛋白B1(HMGB1)],促纤维化相关因子[基质金属蛋白酶-9(MMP-9)、转化生长因子-β_(1)(TGF-β_(1))],氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)]以及肝功、肾功、心肌酶指标[谷丙转氨酶(ALT)、谷草转氨酶(AST)、血肌酐(SCr)、肌酸激酶同工酶(CK-MB)等生化指标]进行比较,依据肺CT影像计算并对比两组的肺纤维化程度评分。随后分别对比两组患者7、14、28 d的病死率并采用Kaplan-Meier法对比两组的生存情况。结果:治疗前两组患者的促炎细胞因子、促纤维化相关因子、氧化应激指标以及ALT、AST、SCr、CK-MB等生化指标比较均无统计学差异(均P>0.05)。治疗后7 d,对照组死亡4例(其中1例为第7天死亡)、干预组死亡3例,两组患者的IL-18、TNF-α、IL-6、HMGB1、MMP-9、TGF-β_(1)均较前升高但干预组低于对照组,MDA较前降低且干预组低于对照组,SOD和CAT较前升高且干预组高于对照组,ALT、AST、SCr、CK-MB虽均较前升高但干预组均低于对照组,差异均有统计学意义(均P<0.05);干预组的肺纤维化程度评分显著低于对照组(P<0.05)。干预组的7 d病死率及生存时间与对照组比较无统计学差异(P>0.05),但14 d病死率显著低于对照组且生存时间显著高于对照组(均P<0.05),然而28 d病死率及生存时间与对照组比较却无统计学差异(均P>0.05)。结论:在常规治疗的基础上联合乌司他丁治疗百草枯中毒,可改善肺纤维化程度及肝、肾、心肌等损伤情况,且可降低14 d病死率并改善生存时间;其机制为乌司他丁可改善患者的炎性反应及氧化应激失衡、改善肺纤维化,进而降低百草枯所致器官损伤。