交替区域入肝血流阻断在原发性肝癌手术治疗中的应用效果及对患者肝功能、营养指标的影响

目的:探讨交替区域入肝血流阻断在原发性肝癌手术治疗中的应用效果及对患者肝功能、营养指标的影响。方法:以我院2018年5月至2022年9月收治的70例原发性肝癌患者作为研究对象,依照其手术方式的不同分为观察组与对照组,每组各35例。对照组实施常规肝血流阻断治疗,观察组实施交替区域入肝血流阻断治疗,对比两组患者围术期相关指标、手术前后的肝功能指标、血清营养指标。结果:观察组患者肝血流阻断时间、术中出血量、手术时长、术后首次排气时间和住院时间均低于对照组(P<0.05)。手术前两组患者血清碱性磷酸酶(ALP)、谷丙转氨酶(ALT)、谷草转氨酶(AST)水平比较,差异无统计学意义(P>0.05);手术后两组患者血清ALP、ALT和AST水平较手术前均升高,但观察组患者血清ALP、ALT和AST水平均低于对照组(P<0.05)。手术前,两组患者血清转铁蛋白(TRF)、前白蛋白(PAB)、血清白蛋白(Alb)和血红蛋白(Hb)等营养指标比较,差异无统计学意义(P>0.05);手术后两组患者TRF、PAB、Alb、Hb水平均升高,且观察组患者TRF、PAB、Alb、Hb水平均高于对照组(P<0.05)。结论:与常规肝血流阻断相比,原发性肝癌手术治疗中采取交替区域入肝血流阻断能够减少患者术中出血量和手术时间,促进患者术后康复,而且能够减轻手术对患者肝功能带来的损伤,提升患者术后营养水平。

基于WPKI的移动办公系统安全模型设计及应用

当前网络安全管理问题面临着严峻的考验,针对现有网络安全模型无法满足基于有线网和无线网的移动OA安全需求现状的缺陷,结合移动OA实际安全需求特点,提出并设计了一种基于WPKI的移动OA安全模型。采用数字证书的认证与授权机制来实现用户身份确认及访问控制,通过数字签名来提供信息的完整性保护与不可否认性,并实现了无线与有线认证系统的统一,成功应用到科茂OA系统中,运行结果表明该安全模型能够很好的保证通信中用户身份安全,保护数据的机密、完整,实现用户行为的不可否认,完全可以满足移动办公的全方位安全需求,可广泛用于各种移动信息系统。

Non-Stokes drag coefficient in single-particle electrophoresis:New insights on a classical problem

We measured the intrinsic electrophoretic drag coefficient of a single charged particle by optically trapping the particle and applying an AC electric field,and found it to be markedly different from that of the Stokes drag.The drag coefficient,along with the measured electrical force,yield a mobility-zeta potential relation that agrees with the literature.By using the measured mobility as input,numerical calculations based on the Poisson-Nernst-Planck equations,coupled to the Navier-Stokes equation,reveal an intriguing microscopic electroosmotic flow near the particle surface,with a well-defined transition between an inner flow field and an outer flow field in the vicinity of electric double layer’s outer boundary.This distinctive interface delineates the surface that gives the correct drag coefficient and the effective electric charge.The consistency between experiments and theoretical predictions provides new insights into the classic electrophoresis problem,and can shed light on new applications of electrophoresis to investigate biological nanoparticles.

Investigation of magnetization reversal process in pinned CoFeB thin film by in-situ Lorentz TEM

Exchange bias effect has been widely employed for various magnetic devices.The experimentally reported magnitude of exchange bias field is often smaller than that predicted theoretically,which is considered to be due to the partly pinned spins of ferromagnetic layer by antiferromagnetic layer.However,mapping the distribution of pinned spins is challenging.In this work,we directly image the reverse domain nucleation and domain wall movement process in the exchange biased Co Fe B/Ir Mn bilayers by Lorentz transmission electron microscopy.From the in-situ experiments,we obtain the distribution mapping of the pinning strength,showing that only 1/6 of the ferromagnetic layer at the interface is strongly pinned by the antiferromagnetic layer.Our results prove the existence of an inhomogeneous pinning effect in exchange bias systems.

A Focus on Interfaces

Interfaces define the bulk.It is widely known that many interesting phenomena occur at the interfaces separating two homogeneous phases of matter.In this opinion piece,I wish to call attention to two recent developments that involve at least one interface.The first development is in desalination-a topic of practical importance in view of the steadily eroding global freshwater supply.The second development involves the use of hydrodynamic eigenmodes to not only determine the position of the hydrodynamic boundary in channel flows-a somewhat surprising proposition,since that position does not coincide with the solid/liquid interface-but also obtain an alternative perspective on thermal fluctuations and their linkage to hydrodynamic boundary conditions in a mesoscopic channel.

A critical path approach for elucidating the temperature dependence of granular hopping conduction

We revisit the classical problem of granular hopping conduction＇s σ∝exp[-（To/T）1/2] temperature dependence, where a denotes conductivity, T is temperature, and To is a sample-dependent constant. By using the hopping conduction formulation in conjunction with the incorporation of the random potential that has been shown to exist in insulator-conductor composites, it is demonstrated that the widely observed temperature dependence of granular hopping conduction emerges very naturally through the immediate-neighbor critical-path argument. Here, immediate-neighbor pairs are defined to be those where a line connecting two grains does not cross or by-pass other grains, and the critical-path argument denotes the derivation of sample conductance based on the geometric percolation condition that is marked by the critical conduction path in a random granular composite. Simulations based on the exact electrical network evaluation of finite-sample conductance show that the configuration- averaged results agree well with those obtained using the immediate-neighbor critical-path method. Furthermore, the results obtained using both these methods show good agreement with experimental data on hopping conduction in a sputtered metal-insulator composite Agx（SnO2）1-x, where x denotes the metal volume fraction. The present approach offers a relatively straightforward and simple expla- nation for the temperature behavior that has been widely observed over diverse material systems, but which has remained a puzzle in spite of the various efforts made to explain this phenomenon.

Isolation,Screening,and Optimization of the Fermentation Conditions of Highly Cellulolytic Bacteria from the Hindgut of Holotrichia parallela Larvae(Coleoptera:Scarabaeidae)

From the hindgut contents of Holotrichia parallela larvae,207 aerobic and facultatively anaerobic cellulolytic bacterial isolates were obtained.These bacterial isolates were assigned to 21 genotypes by amplified ribosomal DNA restriction analysis(ARDRA).A partial 16 S rDNA sequence analysis and standard biochemical and physiological tests were used for the assignment of the 21 representative isolates.Our results show that the cellulolytic bacterial community is dominated by the Proteobacteria(70.05%),followed by the Actinobacteria(24.15%),the Firmicutes(4.35%),and the Bacteroidetes(1.45%).And among the cellulolytic bacteria,some isolates,Siphonobacter aquaeclarae,Cellulosimicrobium funkei,Citrobacter freundii,Pseudomonas nitroreducens,and so on,are reported to be cellulolytic for the first time in this study.Among these isolates,a novel bacterium,designated Pseudomonas sp.HP207,with the highest endoglucanase productivity was selected for further study.The production of the endoglucanase was optimized by varying various physical culture conditions using a submerged fermentation method.Under the optimized fermentation conditions,the maximum endoglucanase activity of 1.432 U mL-1 in bacterial cultures was obtained,higher than those of the most widely studied bacteria and fungi,which are the attractive candidates for the commercial producer of cellulase.And the crude endoglucanase enzyme was also highly thermostable;approximately 55% of the original activity was maintained after pretreatment at 70°C for 1 h.Thus,from the present study,the bacterium can be added up to the database of cellulolytic bacteria,the scarab gut is an attractive source for the study of novel cellulolytic microorganisms and enzymes useful for cellulose degradation.

Flexible magnetic thin films and devices

Flexible electronic devices are highly attractive for a variety of applications such as flexible circuit boards, solar cells, paper-like displays, and sensitive skin, due to their stretchable, biocompatible, light-weight,portable, and low cost properties. Due to magnetic devices being important parts of electronic devices, it is essential to study the magnetic properties of magnetic thin films and devices fabricated on flexible substrates. In this review, we mainly introduce the recent progress in flexible magnetic thin films and devices, including the study on the stress-dependent magnetic properties of magnetic thin films and devices, and controlling the properties of flexible magnetic films by stress-related multi-fields, and the design and fabrication of flexible magnetic devices.

Molecular Hydrodynamics of the Moving Contact Line in Two-Phase Immiscible Flows

The no-slip boundary condition,i.e.,zero fluid velocity relative to the solid at the fluid-solid interface,has been very successful in describing many macroscopic flows.A problem of principle arises when the no-slip boundary condition is used to model the hydrodynamics of immiscible-fluid displacement in the vicinity of the moving contact line,where the interface separating two immiscible fluids intersects the solid wall.Decades ago it was already known that the moving contact line is incompatible with the no-slip boundary condition,since the latter would imply infinite dissipation due to a non-integrable singularity in the stress near the contact line.In this paper we first present an introductory review of the problem.We then present a detailed review of our recent results on the contact-line motion in immiscible two-phase flow,from molecular dynamics(MD)simulations to continuum hydrodynamics calculations.Through extensive MD studies and detailed analysis,we have uncovered the slip boundary condition governing the moving contact line,denoted the generalized Navier boundary condition.We have used this discovery to formulate a continuum hydrodynamic model whose predictions are in remarkable quantitative agreement with the MD simulation results down to the molecular scale.These results serve to affirm the validity of the generalized Navier boundary condition,as well as to open up the possibility of continuum hydrodynamic calculations of immiscible flows that are physically meaningful at the molecular level.