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Multifunctional electrospinning composite fibers for orthotopic cancer treatment in vivo 被引量:2
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作者 Yinyin Chen Shi Liu +4 位作者 Zhiyao Hou pingan ma Dongmei Yang Chunxia Li Jun Lin 《Nano Research》 SCIE EI CAS CSCD 2015年第6期1917-1931,共15页
A multifunctional, dual-drug carrier platform was successfully constructed. Core-sheU structured NaGdF4:Yb/Er@NaGdF4:Yb@mSiO2-polyethylene glycol (abbreviated as UCNPS) nanopartides loaded with the antiturnor drug... A multifunctional, dual-drug carrier platform was successfully constructed. Core-sheU structured NaGdF4:Yb/Er@NaGdF4:Yb@mSiO2-polyethylene glycol (abbreviated as UCNPS) nanopartides loaded with the antiturnor drug, doxorubicin (DOX) were incorporated into poly(^-caprolactone) (PCL) and gelatin loaded with antiphlogistic drug, indomethacin (MC) to form nanofibrous fabrics (labeled as MC/UCNPS/DOX) via electrospinning process. The resultant multifunctional spinning pieces can be surgically implanted directly at the tumor site of mice as an orthotopic chemotherapy by controlled-release DOX from mesoporous silicon dioxide (SiO2) and upconversion fluorescence/magnetic resonance dual-model imaging through NaGdF4:Yb/Er@NaGdF4:Yb embedded in MCfldCNPS/DOX invivo. 展开更多
关键词 electrospinning orthotopic TREATMENT controlled release multiple structure
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