IκB kinase ε(IKKε) is a non-canonical IκB kinase that is extensively studied in the context of innate immune response. Recently, significant progress has been made in understanding the role of IKKεin interferon(I...IκB kinase ε(IKKε) is a non-canonical IκB kinase that is extensively studied in the context of innate immune response. Recently, significant progress has been made in understanding the role of IKKεin interferon(IFN) signaling. In addition to its roles in innate immunity, recent studies also demonstrate that IKKε is a key regulator of the adaptive immune response. Specifically, IKKεfunctions as a negative feedback kinase to curtail CD8 T cell response, implying that it can be a potential therapeutic target to boost antiviral and antitumor T cell immunity. In this review, we highlight the roles of IKKε in regulating IFN signaling and T cell immunity, and discuss a few imminent questions that remain to be answered.展开更多
Host innate immunity represents the first line of defense against invading pathogens and shapes the course and outcome of pathogen infection.Mammals have evolved an array of highly conserved pattern recognition recept...Host innate immunity represents the first line of defense against invading pathogens and shapes the course and outcome of pathogen infection.Mammals have evolved an array of highly conserved pattern recognition receptors(PRRs)that monitor the presence of“non-self”components or danger signals(Akira et al.,2006;Medzhitov,2007).The innate immune signal transduction and viral regulation have been extensively reviewed elsewhere(Zhang et al.,2010),we therefore briefly summarize the signaling cascades that upregulate the transcription of antiviral inflammatory cytokines in response to viral infection.展开更多
基金supported by the Joint Funds of the National Natural Science Foundation of China (U1603126) (to Z. X.)
文摘IκB kinase ε(IKKε) is a non-canonical IκB kinase that is extensively studied in the context of innate immune response. Recently, significant progress has been made in understanding the role of IKKεin interferon(IFN) signaling. In addition to its roles in innate immunity, recent studies also demonstrate that IKKε is a key regulator of the adaptive immune response. Specifically, IKKεfunctions as a negative feedback kinase to curtail CD8 T cell response, implying that it can be a potential therapeutic target to boost antiviral and antitumor T cell immunity. In this review, we highlight the roles of IKKε in regulating IFN signaling and T cell immunity, and discuss a few imminent questions that remain to be answered.
基金supported by the Endowed Scholar Program of UT Southwestern,National Cancer Institute,and American Cancer Society.
文摘Host innate immunity represents the first line of defense against invading pathogens and shapes the course and outcome of pathogen infection.Mammals have evolved an array of highly conserved pattern recognition receptors(PRRs)that monitor the presence of“non-self”components or danger signals(Akira et al.,2006;Medzhitov,2007).The innate immune signal transduction and viral regulation have been extensively reviewed elsewhere(Zhang et al.,2010),we therefore briefly summarize the signaling cascades that upregulate the transcription of antiviral inflammatory cytokines in response to viral infection.
