Dear Editor,The COVID-19 pandemic, which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), has led to millions of lives lost worldwide. The trimeric spike protein(S) decorating the membrane sur...Dear Editor,The COVID-19 pandemic, which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), has led to millions of lives lost worldwide. The trimeric spike protein(S) decorating the membrane surface of the infectious virion is responsible for the attachment and entry by binding to the receptor angiotensin-converting enzyme 2(ACE2) in the early replication cycle(Zhou P. et al., 2020). Two subunits S1 and S2 are included in the trimeric glycoprotein.展开更多
基金supported by funding from Beijing Natural Science Foundation-Haidian Primitive Innovation Joint fund(L192008)the National Key R&D Program(2020YFA0707500,2018YFA0900801,2021YFA1301400)the National Natural Science Foundation of China(31872730 and 32070947)
文摘Dear Editor,The COVID-19 pandemic, which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), has led to millions of lives lost worldwide. The trimeric spike protein(S) decorating the membrane surface of the infectious virion is responsible for the attachment and entry by binding to the receptor angiotensin-converting enzyme 2(ACE2) in the early replication cycle(Zhou P. et al., 2020). Two subunits S1 and S2 are included in the trimeric glycoprotein.
