An efficient and facile approach has been developed for the construction of chondroitin sulfate E(CS-E)oligosaccharide precursors. In this approach, the disaccharide unit with the GalNAc-GIcA sequence was first elonga...An efficient and facile approach has been developed for the construction of chondroitin sulfate E(CS-E)oligosaccharide precursors. In this approach, the disaccharide unit with the GalNAc-GIcA sequence was first elongated to form tetra-and hexasaccharides followed by the introduction of anomeric groups via glycosylation couplings. A number of CS-E tetra-and hexasaccharide precursors were prepared in high yields.展开更多
A new and facile procedure was developed to synthesize novel 5-0- (6′-O-modified)-desosamine 14-membered ketolides by adopting different protective strategies and comparing various glycosylation conditions. Two trich...A new and facile procedure was developed to synthesize novel 5-0- (6′-O-modified)-desosamine 14-membered ketolides by adopting different protective strategies and comparing various glycosylation conditions. Two trichloroacetimidate donors, with Lev or Ac substituent groups at the C-6 position, were synthesized to couple with the erythronolide. Several novel 5-0- (6′-O-modified)-desosamine 14-membered ketolides were obtained to verify the utility of the method.展开更多
基金supported by the CAMS Innovation Fund for Medical Sciences(Nos.CIFMS 2016-I2M-3-009 and CIFMS 2017I2M-3-011)
文摘An efficient and facile approach has been developed for the construction of chondroitin sulfate E(CS-E)oligosaccharide precursors. In this approach, the disaccharide unit with the GalNAc-GIcA sequence was first elongated to form tetra-and hexasaccharides followed by the introduction of anomeric groups via glycosylation couplings. A number of CS-E tetra-and hexasaccharide precursors were prepared in high yields.
基金supported by the CAMS Innovation Fund for Medical Sciences(Nos.2017-I2M-3-011 and 2017-I2M-1-012)
文摘A new and facile procedure was developed to synthesize novel 5-0- (6′-O-modified)-desosamine 14-membered ketolides by adopting different protective strategies and comparing various glycosylation conditions. Two trichloroacetimidate donors, with Lev or Ac substituent groups at the C-6 position, were synthesized to couple with the erythronolide. Several novel 5-0- (6′-O-modified)-desosamine 14-membered ketolides were obtained to verify the utility of the method.
